3ONT


Conserved Protein Domain Family
Spot_14

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pfam07084: Spot_14 
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Thyroid hormone-inducible hepatic protein Spot 14
This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.
Statistics
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PSSM-Id: 399817
View PSSM: pfam07084
Aligned: 25 rows
Threshold Bit Score: 193.691
Threshold Setting Gi: 972981358
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ONT_A         4 QVLtKRYP-KNCLLTVXDRYSAVVRNXEQVVXIPSLLRDVQLSGPGGSVQ--------------DGAPDLYTYFTXLKSI 68  house mouse
XP_005995320   3 QIY-ESNNqKHSLINAMNRFIGAVNNMDQTVMVPSLLRDVPLEDAAKDDVqvhnsssnetasyyPDLGDMYSYYVLLKSI 81  coelacanth
XP_006091128   2 QVFtTRYP-KNCLLTVMDRYSAVVQNMEQVVMFPSLLRDMQPSAHGCEAQ--------------AGAPSLYNYFTMLKAI 66  little brown bat
XP_019652007   2 QGQtKHYP-KNCLLTVMDRYSAVVRNMEQVVMIPSLLRDVQLNGQGQQAQ--------------DGAPDLYNYFTMLKAI 66  giant panda
XP_005323300   2 PVLtKRYP-KNCLLAVVDRYLAVVCNMEQVVMIPSLLRDVHLGGHGGQAQ--------------MGAPDLYTYFTMLKTI 66  thirteen-lined ...
XP_002754822   2 QVLtKRYP-KNSLLTVMDRYSAEVRNMEQVVMIPSLLRDAQPSGHGGPAK--------------ARASDLYTYFTMLKSI 66  white-tufted-ea...
ELV13887      58 QVPaKSYP-KNCLLTVMDRYSATVRNMEQVVMIPSLLRGVQLGGPGAEAEa------------hAGAPDLYTYFTMLKTI 124 Chinese tree shrew
Q1LUV9         3 QIC-DSYNqKNSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLDQEEEKEVt------------sFQDGDMYGSYVLLKSI 69  zebrafish
XP_015219485   3 QIA-DSYNqKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLEYEEKDEVnnslrtgspgaagyFSDRDMYSYYVLLKSI 81  spotted gar
Q6P8B2         3 QIS-DTYNqKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLDMEVKDEVhntng-----atnyFSRRDMHGYYILLKSI 76  tropical clawed...
3ONT_A        69 CVEVDHGLLPREeWQAKVagnetseaenDAAETEEAEEDRis-eELDLEAQFHLHFCSLHHILTHLTRKAQEVTRKYQEX 147 house mouse
XP_005995320  82 RNDIEWGVLQGE-DRKKDk--------vTTMDISRREDLDg---DEDLEKQFRYHLSGLHNVLTKLTRKANTLTNRYKQE 149 coelacanth
XP_006091128  67 RVDVEHGLLPQKeGQVKMaggganeaenEAAEMEEGEEvl---gQLDLQAQFHLHFSSLHHILTHLTVKAEEVTRTYQEI 143 little brown bat
XP_019652007  67 RVDVDHGLLPREeWWSKVaggraheaeqEAGETEEVEDKRvl-gQLDLEAQFHLHFSSLHHILTHLTLKAEEVTRKYQEI 145 giant panda
XP_005323300  67 RMDVEHGLLPREeWQAKVagrkadeagkEAAETEEAKEEvs--gELDLETQFHVHFSSLHRILTHLTVKAQEVTRKYQEM 144 thirteen-lined ...
XP_002754822  67 RVDVDHGLLPREeWQAKVasseakeaenGTAKTEEVVDESas-gELELEAQFHLHFSSLHHILTYLTEKAQEVTRKYQEM 145 white-tufted-ea...
ELV13887     125 CVDVDHGLLPREeWQAKMvde----venEAAETEEELKENkvsgRLDLEAQFHLHFCSLHHILTHLTLKAQEVTRKYQEL 200 Chinese tree shrew
Q1LUV9        70 RNDIEWGVLQAE-ERRKEkhg----vttTSLEVSRIEPND-----KDLEKLFHYHLSGLHTVLAKLTRKANTLTNRYKQE 139 zebrafish
XP_015219485  82 RNDIEWGVLQGE-ERKKDkl------gaSALDLSRIEPEEe---EEDLQKMFHFHLSGLHTVLSKLTRKANTLTNRYKQE 151 spotted gar
Q6P8B2        77 RNDIEWGVVQGE-DRKKDk--------lSNMEISRLEDGDg---EEDLEKQFHYHLSGLHTVLNKLTRKAHLLTNRYKEE 144 tropical clawed...
3ONT_A       148 TG 149 house mouse
XP_005995320 150 IG 151 coelacanth
XP_006091128 144 TG 145 little brown bat
XP_019652007 146 MG 147 giant panda
XP_005323300 145 TG 146 thirteen-lined ground squirrel
XP_002754822 146 TG 147 white-tufted-ear marmoset
ELV13887     201 Iq 202 Chinese tree shrew
Q1LUV9       140 IG 141 zebrafish
XP_015219485 152 IG 153 spotted gar
Q6P8B2       145 IG 146 tropical clawed frog
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