Conserved Protein Domain Family
NamZ_N
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pfam07075: NamZ_N (This model is not part of the current CDD release)
Exo-beta-N-acetylmuramidase NamZ, N-terminal
NamZ is an exo-beta-N-acetylmuramidase which catalyzes an exo-lytic cleavage of beta-1,4-acetylmuramic acid from from the non-reducing ends of peptidoglycan chains and it is a founding member of a new family of glycosidases (GH171). NamZ consists of a N-terminal catalytic domain with a Rossmann-like fold (represented in this entry) and a C-terminal auxiliary alpha/beta domain.
Links
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Statistics
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PSSM-Id: 517549
Aligned: 218 rows
Threshold Bit Score: 146.806
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_014264956 1045 GLLTNQTG-LDSQGRRTVDILHSpdlsedkIHLVTLFSPEHGIFGKQDTT--SIA-AEVD----P-ATGLHVTSLYGAKd 1115 Granulicella ...
WP_013907780   23 GLLCHQAS-ILPNLTPAWVALKAkf----sQKLKLLFSPQHGLFGEKQANmiASY-EIVE----P-ETGVPVISLYGPR- 90   Thermodesulfa...
WP_013909233   29 ALLCNQAS-VDYNFTPVFILFKKqf----kGDFKLIFSPQHGLFSEKQANmiFSE-DEIE----P-ITQTPVISLYGKR- 96   Thermodesulfo...
WP_014802197   24 ALLVNQSS-VAADGRYLFEALIAq-----gYKPEKIFAPEHGLFGTEQDQi-TVA-DEVD----G-FTGLKAVSLYGQTk 90   Turneriella p...
CCY37405       23 AVLCNQSAwDPERQEYLFESLYRn------GRLRKVLFPADGIFGEKPDRslGEApVYAS----LgLDDCLFVPLHTGPs 92  
AGY53847       23 GILCNQVAwQPDKGEYLFETLYKr------GRLKRVFTPEHGLFGELQD---QVTlDDTEvygkLgLEGCEFVSLYGTDe 93  
Q8F8L1         23 GMITNQSA-FGSDGEYHFQSIHKr------YDLKKIFLPEHGLFAELQD---QVSgSSLR----YnLDEVEFINLYGDQe 88   Leptospira in...
Q8KAU5         22 GLIANQTS-VSMQLEYSWMLLKRa-----gVELTRIFSPEHGLFAIEQD---QIA-VGHQ----P-DIGCEIVSLYGDSe 86   Chlorobaculum...
WP_012509382   22 GLIVNQSS-VTPDLKYSWNALREr-----gIHVRKIFSPEHGLFATEQD---QIA-VTCQ----P-EIGCEVISLYRDTa 86   Pelodictyon p...
WP_011744112   22 GMIVNQTS-VTSDLRYSWNVLREk-----gLDIRKIFSPEHGLFATEQD---QIA-VGSQ----P-VPDIELVSLYGSSs 86   Chlorobium ph...

WP_014264956 1116 adRRPSHEQLKDLDAVVIDLQDAGVRFYTYEAVTGYFLEAAAREKnefhhdLEILVLDRPNLIGGEQVQGPISDAGLESY 1195 Granulicella ...
WP_013907780   91 --LAPEPEHLAEIDILLVDLQDVGTRVYTYIWTLLLTMKACSKNG------VKLIVLDRPNPIGG-KIEGPILEEKFFSF 161  Thermodesulfa...
WP_013909233   97 --LKPEKEHLDEVDIVFVDLQDVGCRVYTYIWTLYLLMEACEENG------KKVVIFDRPNPIGA-QIEGPLLEPKYFSF 167  Thermodesulfo...
WP_014802197   91 eeLKPRASDLGGLETLVVDIQDIGCRYYTYAYTMAFCIEACAALG------IEVIICDRPNPLGGVVVEGGIVHKGFESF 164  Turneriella p...
CCY37405       93 geLVMDAGVLEDVDALIIEYQDTGSRYDSLTALLYEIFQLIHHSGl----sLSVYILDRENICG-RSVEGTTLCPGSSEA 167 
AGY53847       94 nsLSASAAKLEDLDALIIELQDVGSRYYTFTTTVFNLFKVLKKHDl----nLSIYIVDRMNPAG-RQVEGTMLEKGYGSF 168 
Q8F8L1         89 ssLIPDSVSLEGLDIVIIDIRDTGARYYTFLTTAYYFLEEISKWNssgkneISVIIFDSTNPAG-KKIEGSPLQKEFESF 167  Leptospira in...
Q8KAU5         87 hsLAPARELLDGLDLVLFDIQDVGSRYYTYVNTLALFMKAAEGLD------IEIMVLDRPNPLGGSLIEGPQLDPAFHSF 160  Chlorobaculum...
WP_012509382   87 asLLPDKRVLDNLDLILFDIQDVGSRYYTYINTLALFMEAVSGMD------LEIIVLDRPNPLGGSLVEGPLLDPSFRSF 160  Pelodictyon p...
WP_011744112   87 dtLIPDCTTLDDLDLILFDIQDVGARYYTYVNTLALFMEAATGRD------LEIMVLDRPNPLGGAVVEGPLLDMAYRSF 160  Chlorobium ph...

WP_014264956 1196 TDYMPLPVRNGLTLGELAQYINGEatstlahgdalfaeadpanrtratqapssKGLGAHLTVIPMQHWSRAEFFDNTGLP 1275 Granulicella ...
WP_013907780  162 VGLAPIPMRHGLTIGELALYLCQK-----------------------------FSLDLELEVIPMEGWSRDMFFPETGLP 212  Thermodesulfa...
WP_013909233  168 VGMDTLPLRHGLTIGEIANLFKKRk---------------------------fKNL--DLEVIKMKGYKKNFLYPETGRS 218  Thermodesulfo...
WP_014802197  165 VGAYPLAVRHALTIGEVARLLNAT-----------------------------EKWNAKLTVIELKNWNRNWLYPQTEGL 215  Turneriella p...
CCY37405      168 AGIEGIPHRHGLTLGELANLFYSEiga-----------------------------rfPLHIISYMVRPATQY----LMP 214 
AGY53847      169 IGIEGIPHRHGLTFGELTNLFYNEina-----------------------------kfPLHIIAYTAEKVSKD----LLP 215 
Q8F8L1        168 VGVRGVLHRHGLTPGKLLSYYQKEfhl-----------------------------nvKIRIVNKGWYKKKDS----EFS 214  Leptospira in...
Q8KAU5        161 VGVMPLPVRHGLTAGEIAHFYRNY-----------------------------KKLDLNLNVIPMQGWSRQMLFPETCLP 211  Chlorobaculum...
WP_012509382  161 VGIFPIPVRHGMTVGELALLYRDI-----------------------------KKLDINLHVIKMDGWQRSMLFPETGLP 211  Pelodictyon p...
WP_011744112  161 VGIFPVPVRHGMTPGELALLYRDW-----------------------------KKLDIRLSVLSMRGWSRTMLFHETGLP 211  Chlorobium ph...

WP_014264956 1276 W-VNPSPNLRSVT 1287 Granulicella mallensis
WP_013907780  213 W-VSPSPNMPRFE 224  Thermodesulfatator indicus
WP_013909233  219 W-VFPSPNIPTWE 230  Thermodesulfobacterium geofontis
WP_014802197  216 W-VQPSPNMPTVD 227  Turneriella parva
CCY37405      215 WsIPPRQDVPGLF 227 
AGY53847      216 WsIPPSPNIPGLF 228 
Q8F8L1        215 W-IPPSPNIPFRS 226  Leptospira interrogans
Q8KAU5        212 W-VPPSPNMPSFE 223  Chlorobaculum tepidum
WP_012509382  212 W-IPPSPNMPTFA 223  Pelodictyon phaeoclathratiforme
WP_011744112  212 W-VPPSPNMPTVE 223  Chlorobium phaeobacteroides
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