8PHD,4ZGO


Conserved Protein Domain Family
D123

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pfam07065: D123 (This model is not part of the current CDD release)
D123
This family contains a number of eukaryotic cell division cycle 123 (Cdc123, also known as D123) proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate. D123 proteins are regulators of eIF2, the central regulator of translational initiation. Family members include ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is found in eukaryotes as well as NCDLVs and diverse bacteria. In eukaryotes, the domain is found in both the CDC123 enzymes and a related clade of proteins found in amoeboid organisms, while in bacteria it is observed embedded in polymorphic toxin loci.
Statistics
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PSSM-Id: 517542
Aligned: 114 rows
Threshold Bit Score: 251.693
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8PHD_A        34 WYPFFRGVTIKSVILPLPQNVKDYLLD--------DG--------TLVVSGRDDPP-------------------THSQP 78  human
Q9M0V1        14 WYPRFKSLTIKTKFHKLPESFINYLID--------DSg------pFLLPHSVTNEDamp--------------nrVHNFE 65  thale cress
XP_009121646  14 WYPKFKSLTIKTKLHKLPESFVNYLLD--------DSv------pFLLPSSVTNQNamp--------------nrIQNPD 65 
XP_002276138  14 WYPKFKSVSIKTLIHELPESFVEYLLD--------DHg------pFLLPVSVINEDalp--------------nrIHNSE 65 
XP_006373038  14 WYPKFKSGSIKTVIHELPESFVEYLLD--------DSg------pFLLPHSISGEDalp--------------nrIHNPV 65 
XP_004230739  14 WYPRFKSDSIKTMIHELPESFIEYLMD--------DHg------pFLLPLSIDDNDalp--------------nrIHKPE 65 
XP_044974316  14 WYPLFRRHTVPTAIIPLPPAFLRYLAGrpaypdgaDEgeqgpplpFVLPTLTSGRApfpplq-------ghfpdpVSLLD 86 
XP_001007656  96 WPEQLKKLTYKTKYIKVDQNLYDYLEE--------DG--------IYIHPRYQKNSsqnylleknkdfhlqqqknEEEQN 159
XP_067739271  24 WYPALKRVSIKGEVVPLPSDFVSLLLA--------DG--------VTLPTAP---------------------------- 59 
XP_014622706  14 WYPKFKSVSFKTLIHQLPESFIQYLLD--------DSg------pFLLPDSVLNEDalp--------------nrIHNPD 65  soybean
8PHD_A        79 DSDDEaEEIQWSDDE--NTAT-L---TAPEF----PEFATKVQEAINSLGGSVFPKLNWSAPRDAY-WIAMNSSLKCKTL 147 human
Q9M0V1        66 EEDDF-QVPEEASDDepLNR--------PSF----PELEIEIRESIETLGGTIIPKLNWSSPKDAA-WISPSQNLSCTCF 131 thale cress
XP_009121646  66 EGEDD-ESSSSDDETdpPPPPs------PSF----PELEIEIRDSIEALGGSIFPKLNWSAPKDAA-WISPSQSLSCSCF 133
XP_002276138  66 EEEDY-QVSEGSGDEaeQPPSp------PSF----PELELKIKESIESLGGAVFPKLNWSAPKDSA-WISTTGTLRCTSF 133
XP_006373038  66 DEEDF-QVSEGSGDEseQPPLp------PSF----PELELNIKESIKTLGGAVFPKLNWSAPKDSA-WISPSGSLRCTSF 133
XP_004230739  66 EEEDF-EVSEGSEDEseQPSPp------PSF----PELEMKIKESIESLGGSVFPKLNWSAPKDAA-WISSTGNLCCNSF 133
XP_044974316  87 RDNTD-PLFDSDSDDegPPP--------PAF----PELEAAVDSAIADLGGAALPKLNWSAPKDAV-FMAADGTVRCTCF 152
XP_001007656 160 KQDDS-FNQDYDDEDh-----------dFKFrifsKEFEEQVKEAFDDF-ESVFVKLNWRAPRDTEnWLHg---LQIDNL 223
XP_067739271  60 --VAS-GIEDDGDEDeeDAASaLtdeQLRVI----STVREQVEKVLEDFGGKLFPKTNWSAPRDAA-WML--GSLKCTSF 129
XP_014622706  66 EEEDF-QVSEGSGDEaeASAP-------PSF----PELELKIKDFIESLGGAVFPKLNWSAPKDSA-WISTSGTLRCISF 132 soybean
8PHD_A       148 SDIFLLFKSSDFITRDF--T-QPFIHC----------------------------------------T--DDSPDPC--- 179 human
Q9M0V1       132 NEIALLFRSSDSLTHDL--F-NAYDSCs------------------------------------------DKVSSRP--- 163 thale cress
XP_009121646 134 SEIALLLRSSDSILHDL--C-NAYDSCs-----------------------------------------dDKASSRP--- 166
XP_002276138 134 SEIALLLRSSDSLIHDL--C-HAYDSCs------------------------------------------DKSLSRP--- 165
XP_006373038 134 SEIALLLRSSDSLVHDL--C-HAYDTCs------------------------------------------DKTLSRP--- 165
XP_004230739 134 SEVAILLRASDSLVHDL--C-HVYDSCs------------------------------------------DKTVSRP--- 165
XP_044974316 153 AEVAMLLRASDCVAHDL--V-SARPSCqdfvrakpvrrnatqgsretingagvlsdhsdvidgqeedDgqVCSDDETwvd 229
XP_001007656 224 EDLLTVLKSSGILAELLeeYkDQFGLCsti-----------------------------------ntEnqFEQVQQQ--- 265
XP_067739271 130 EDVFLLLQSSDFVVHDL--T-QPYIGCs------------------------------------------VEKEKKP--- 161
XP_014622706 133 SEIALLFRASDSLVHDL--C-HAYDSCq------------------------------------------DKSSTRP--- 164 soybean
8PHD_A       180 --IEYE----LVLRKWC-ELIPGAEFRCFVKENKLIGISQRDYtQYYDHISKQKEEIRRCIQDFFKkHIqy-----kFLD 247 human
Q9M0V1       164 --ESFY----LALRKWYpSLKPEMEFRCFVKSNELVGICQREVtTFYPVLLNEKDLLKGLIEEFFDdKIrf-----eFES 232 thale cress
XP_009121646 167 --ESFF----LALRKWYpSLKPEMEFRCFVKANELVGVCQREVtTFYPVLVSEKEALKGLIEEFFDvNVrs-----vFEL 235
XP_002276138 166 --PNFY----LALRKWYpSLRPEMEFRCFVRDRLLVGISQREVtGFYPALLEKKSALEVVIREFFMdKVsq-----tFEL 234
XP_006373038 166 --PSFF----LALRKWYsSFLPEMEFRCFVRDKQLVGISQREVtTFYPTLLEKKNDLLWLIEEFFTdNVrl-----kFES 234
XP_004230739 166 --PKFF----LALRKWYsSLRPEMEFRCFVRNGILVGVSQREVtGFYPALVEKKDELITIVQRFFMyKVkg-----nFES 234
XP_044974316 230 dgFQYY----LALRKWYsGLRPESEFRCFVRGRKLVGVSQRDPsAYYPSLPGWSAEVQPKIEDFFEdVVep-----qFAS 300
XP_001007656 266 --IDSQmglyLILKKWY-NLHKHMMVRCFVRNKKLIAISQRHCsSVNRTIEEFGDLFSQKISSYFYeKIap-----fFEE 337
XP_067739271 162 --RESY----LVLKKWC-NFLDSMLFRCFVVGHRLVAVSQRNCdEFYEFLPDQQDELCELMYEFYKkNFrrteggfiFPD 234
XP_014622706 165 --QNFF----LALRKWYpSLQPDMEFRCFVRNQKLIGISQREVtTFYPVLLEKKNDLLFLIQAFFInHVra-----kFES 233 soybean
8PHD_A       248 EDFVFDIYRD-S-RGKVWLIDFNPFGEVTDSLLFTWEELI---------SENnlngdfsevDAQEQDSPAF--RCTnSEV 314 human
Q9M0V1       233 ENYTFDVYVTkE--RRVKLIDFNTWCGSTLPLMYTWEELE-----------K---------IHGECDELEL--RIVeSRL 288 thale cress
XP_009121646 236 EDYVFDVYVTkE--RRVKVVDFNTWCGSTLPLMFSWEELE-----------G---------FRRVGGELEL--RIVeSRR 291
XP_002276138 235 ENYTFDVYVTmD--DRVKLVDFNPWGAFTLPLLFTWEELE----------QN---------CAEEGHGVEF--RIVeSQS 291
XP_006373038 235 ENYTFDVYVMkD--GRAKILDFNPWGAFTLPLLFTWEELE----------QN---------LREEEDGVNF--RIVeNQC 291
XP_004230739 235 ESYTFDIYVTnD--DRVKLLDFNPWGAFTLPLLFTWEELE----------VN---------SNKEGDHLEF--RLVeSQC 291
XP_044974316 301 ENYTFDVYVRaD--GRVKLIDFNPWGGYTLPLLFTWEELE-----------E---------EQRGEEELEF--RVVmQQG 356
XP_001007656 338 NNYVFDLYIGiApNYKLRLLDINPWRGHTNPLLLDWDQLE---------KID---------TEEFGQDKKIfiQYVrTES 399
XP_067739271 235 ANYVFDVYVDkR--HRVYLLDVNVFGAVTDTLLFSWEELLelqtgspatAQD---------AEDEYHVIDF--RIVeSKK 301
XP_014622706 234 ENYTFDVYITkD--DRVKIVDFNPWGAFTLSLLFTWDELD-----------H---------IHSEGNDVEF--RIVeDRC 289 soybean
8PHD_A       315 TV-QPSPYLSYRLPKDFVDL 333 human
Q9M0V1       289 SV---LPGLKTAVPYDYLDV 305 thale cress
XP_009121646 292 GV---LPGLKTAVPYDYIDV 308
XP_002276138 292 AV---RPGLKTAVPYDYLAt 308
XP_006373038 292 GI---RPGLKTAVPRDYLDT 308
XP_004230739 292 GV---RPGLKTAVPYDYLDT 308
XP_044974316 357 AV---RPGLMTAIPYDMLDW 373
XP_001007656 400 DViI-EDLSAYRVPEDMLfd 418
XP_067739271 302 GI-RANPLSGYRAPTDLVDH 320
XP_014622706 290 AV---RPGLKTAVPFDYLDT 306 soybean
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