7OS2


Conserved Protein Domain Family
Hep_59

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pfam07052: Hep_59 (This model is not part of the current CDD release)
Hepatocellular carcinoma-associated antigen 59
This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 (HCA59). Family members are found in a variety of eukaryotes, such as fission yeast where telomere length and silencing protein 1 (Tls1) is required for telomeric heterochromatin assembly as well as telomere length control. Homologs in Arabidopsis are known as Cop1 suppressor 2 (CSU2). Csu2 inhibits constitutive photomorphogenic 1 (COP1) E3 ubiquitin ligase activity. Furthermore, CSU2 is required for primary root development under normal light growth condition.
Statistics
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PSSM-Id: 517535
Aligned: 80 rows
Threshold Bit Score: 41.5615
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7OS2_C       105 SFSAE-TNRRD--EDAD---MMKYIETELKKrkg------------------------iveHEE-------QKVKpKNAE 147 human
XP_002953356 200 vkaksiATQQD--EDAH---MQKYIEEQLAVrlg------------------------ktaAQVsedeeldPEAKkRKIE 250
XP_005849690 102 fkrerrlHSED--EDVN---MKKYVEEQLAKrmgr----------------------pgqeEEEaaaaeaeRRARmQDPL 154
XP_002900276 112 QFTGQ-SATTE--KDQHvelMNKFIEERLQKkrk-------------------------idGKQnagdvgdAAAAlKTAE 163
8_pfamImport   1 QFTGQ-SATTD--KEQHeelMNKFIDVKLSQmktkkq------------------kesgtqQTEhyqqmdeASAAlKRAE 59 
XP_002508362  73 QFAAG-AAVDVdgEDPN---MLRYIEQELAKrrgaggd----------------eggdgagTSGggaksaeER------- 125
XP_009409915  95 TFAQE-TAVTI--EDPN---MLKYVEQELAKrrgk-----------------------kidSSEkeekdpmDE------- 138
XP_003292079 107 SFTAHnEDKQE--VNLH---LEKYINEQLELkkqkqkq----------------sktdnndNNNnennsntELKEsS--- 162
XP_020427764 126 SFVTH-SENNK--VNIH---MEKYINEEMQRrkqeqlynkqvnt-----tvqqssketnqdIDNnnnkdvlQEKIeEHKA 194
XP_004367162 132 SFTIA-TEKNE--TNVH---LEKFLAKEMEKkkieikhkltgglmgttehrkeeddenkqtKDNnanntttKIKTdEDS- 204
7OS2_C       148 DC--LYELPenir---vssaKKTEEMlsnqML---SGIPEVDLGIDAKIKNIISTEDAKAR 200 human
XP_002953356 251 AE--LYAVPadf------knTLEQEVvlpgLV---STLSEVPLSARDKLASIEATEALKRK 300
XP_005849690 155 ----LAAMPegl------qkRQQDTElgpsWV---AGITEVPLSMEQKLANIEATEAAKKQ 202
XP_002900276 164 DR--LFELPehlnpdvpsssKNYDEGteggMLmgnTGIAEVELPSSY----AERTEKATKR 218
8_pfamImport  60 DQ--LFELPehlipdvssriEGNNDGtdggMLlgsAGIAEVELPSMYSEKTVAATRKA--- 115
XP_002508362 126 ----LWDTPdel-----rvkKTEGEEtadrWL---TGIVEVQLPADYKIKNIEATERAKAK 174
XP_009409915 139 ----LYVVPehl-----kvkKRNSEEsstqWT---TGIAEVQLPIEYKLRNIEETEAAKKL 187
XP_003292079 163 ----LFETPehlkr-nekkqNEDKTN----WV---AGIAEVQLPEVFKYKNMVETEKARDA 211
XP_020427764 195 LQqsLYETPshllvnkgrkkEEDKTN----WV---AGISEVVLPTKYKIKNILETEEAREK 248
XP_004367162 205 ----LYETPehlavkktrkkEEDKTN----WL---AGISEVSLPTSYKIKNIQETEDARSK 254
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