5UJ8,6WGC


Conserved Protein Domain Family
ORC3_N

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pfam07034: ORC3_N (This model is not part of the current CDD release)
Origin recognition complex (ORC) subunit 3 N-terminus
This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolyzis, thus, it is called AAA+ like.
Statistics
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PSSM-Id: 517528
Aligned: 40 rows
Threshold Bit Score: 214.055
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UJ8_A          1 MATSSMSKG------------CFVFKPNS-----------------------------K----KRKI----------SLP 25   human
XP_001959632    5 DPTISVSKG------------CFVYKNGA-----------------------------T----RAGK----------KAS 29  
XP_002049232    2 DPTISVSKG------------CFVYKNGA-----------------------------T----RANK----------KTP 26  
XP_002068690    2 DPTISVSKG------------CFVYKNGA-----------------------------TraakSKTT----------PNK 30  
Q0IY07         17 EPFYVLHKGgaa------assSSSSAPSL-----------------------------PssgrARRRidvsglaspnPKP 61   Japanese rice
Q6E7H0         22 SDTAENDIR------------PFFVLHKA-----------------------------SsgnhNGKLtgivkskrriESP 60   thale cress
XP_001421719   25 KTNDGLKSG------------VFVLKSAR-----------------------------AaprgDEAS----------RLN 53  
XP_003063429   46 KRTDSLNQG------------VFILRRAP-----------------------------Aq--pKRFT----------ARK 72  
KDE06537       28 APQAELTEGnshghnnrgqnnALSADDTA-----------------------------RqgrsARGRdv------idTTS 72  
Q55BR6         95 SKGDDDDDGdyvggddsssddEYFGNPTVlnnypttmnnvdlnfptffllnedmkkrkQkikeDGNNeeikkieqeeKMI 174  Dictyostelium...
5UJ8_A         26 IEDYFNKGKNEp-------EDSKLRF-ETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDlggq--- 94   human
XP_001959632   30 SKRKHSVGSSSpsnllgteITGQPFY-ETYNQTWRQISSHITDLQQRSYARTLDQLVEFVVSQDATDD------------ 96  
XP_002049232   27 SKRKRTEATSSllg---keITTQPFY-AAYTECWNQLHSHIVQLQMASNARTLEQLVEFVTGEGASNMDNTE-------- 94  
XP_002068690   31 SKRKRSLGNSSllg---peITSQPFY-TAYGEIWQQLHDHILQLQQESYSRTLDQLVQYLETECGSQVEDSE-------- 98  
Q0IY07         62 GKRSRDDDAAEddd--ddeLYERLRL-DAFHRVWSKIQSTINEVLRGISLKLFDQVLRWVQESFSAVRSIARPsaaevrq 138  Japanese rice
Q6E7H0         61 SPKIAKRSEVEsveeedgqFFSTLRF-KVFETVWSKIEKTIEDVLRNSNSKVFSGIHDWIRESFESIISSGALklseavr 139  thale cress
XP_001421719   54 AFEPVLRDETR--------GARERRA-AACARAWEALDGHCQRVADEANAEAFARVRRFVREQGATRVERAREteekn-- 122 
XP_003063429   73 SFKPLVPDETV--------EGLEARW-DAYERSWASTDAHVSRVLADANRGAFEKLEAFVRGDFAERVALRDAnggalp- 142 
KDE06537       73 AKARLQQQQQQafd---ffDSSHQSWiQPYTRAWSAAAQRIQSTLSTVHHSSLDEITAFANHCAGQGSRPSLAeslt--- 146 
Q55BR6        175 IQEYQNEEILKffgdrscfKQTQLAY-EAMVQCLKDLKESIERMFKVVSVKTLGDISSFISMSYPKKSLLDIRdialeli 253  Dictyostelium...
5UJ8_A         95 -------iklrEIPTAALVl-GVNVTDHDLTFGSLTEALqNnv----tpYVVSLQAKDCPD---MKHFLQKLISQLMDCC 159  human
XP_001959632   97 -----------LLPTAALLt-GINQPDHLSQFDALTRRL-Hdqr---saQVCVLQSRDCST---LKAAVESMVFGLVEDD 157 
XP_002049232   95 -----------MLPTAALLt-GINQPDHLKQFETLTQRL-Haeq---aaRVCVLQSRDCAT---LKAAVECMVYSLMDDQ 155 
XP_002068690   99 -----------ILPTAALLt-GINQTDHLKQFEALTQRL-Qsr-----aKVCVLQSRDCST---LKGAIESMVFNLIEGQ 157 
Q0IY07        139 pyplltdvicrKIPTAFVLtkNAEFVDDITTFRDLAEYL-Esn----gcHLAKLSATELSEkngVGCCFRSLLRQLLSDV 213  Japanese rice
Q6E7H0        140 sypvltqasskQLLTAMVLtrNLEMVDDLLTFEELELHL-Ksq----gcHVAKLSSMDFSAksgVGGCLRGLLRQFVMPT 214  thale cress
XP_001421719  123 ------nggdrRVPVGVVLagGVNSDDHEETFAALTKSL-Rksg---daHVALLRSRDLKA---RAGAGTGGLGVAFGVI 189 
XP_003063429  143 ------qsvaqRVPVGLVLagGVNSDDHEETFTKLTRHL-Raa----gcHAALLRSRDLKA---RAASGGGSGGGGGSVG 208 
KDE06537      147 --------agsLLAVGLLI--GANPGASALLFSSLT-------------RHLVLPHHDQTT---ANSAPPSLVSRIssrd 200 
Q55BR6        254 g--qsiddsihHIPTSILYt-SSSSPEVAQLFQSVPSNV-MmrikshqpFSSDISSHLCEP---PTITLNPDCCNTFKST 326  Dictyostelium...
5UJ8_A        160 VDIKS-------------KEEE-----SVHVTQRKthys--------------mdsLSSWYMTVTq-------------- 193  human
XP_001959632  158 GGEEL-------------GEEEedvaeRDRKRLRRsqct--------------mkqLKSWYMNNFss------------- 197 
XP_002049232  156 SELVD-------------LEDAddereRDRKRLRRtqct--------------mkqLSAWYANNFgd------------- 195 
XP_002068690  158 LEQDS-------------EELEqeiedRDHKRLRRsqct--------------mkqLNSWYSNNFql------------- 197 
Q0IY07        214 PDVadi------------------------------------------------faLASWYSAAEn-------------- 231  Japanese rice
Q6E7H0        215 VDVadv------------------------------------------------tiLASWYRENKn-------------- 232  thale cress
XP_001421719  190 MR----------------QLd------RTGGHWGGksm----------------raLRRWHEETSgarrdgliaastvps 231 
XP_003063429  209 GGAVGattiaggggggggGGGGlgvatRCILTQLQaatrgggtagnlrisgrsvrhLKRWYQEVTieefndaprgggglg 288 
KDE06537      201 -----------------------------------------------------cvsLKSALRSVIsgfmgrpkfddsdee 227 
Q55BR6        327 VSTICh-----------sLTKDydvtkFPSPHFED---------------------LSRWYSNYFsipliqevielfkqq 374  Dictyostelium...
5UJ8_A        194 ---------------------------------------------------------------------Ktdpkmlskkr 204  human
XP_001959632  198 --------------------------------------------------------------------eR---------- 199 
XP_002049232  196 -------------------------------------------------------------------vdK---------- 198 
XP_002068690  198 -------------------------------------------------------------------eqR---------- 200 
Q0IY07        232 ---------------------------------------------------------------------Y---------- 232  Japanese rice
Q6E7H0        233 ---------------------------------------------------------------------H---------- 233  thale cress
XP_001421719  232 pignaltvynggdsrasgegddvrarggkkraatdsratsparrskrrarddveragddertlypviqgR---------- 301 
XP_003063429  289 gdrdgdrggdrggnenvnvngd-----------gdgdataersyalrarpadaaipsdpalaaarvirgP---------- 347 
KDE06537      228 ddegeavvssgl-------------------------------ksatlpaddvrnlcvwyahkyrntqqR---------- 266 
Q55BR6        375 qqqqqqqqqqq---------------------------------qqqqqqqqqqqqqqqqkdkleeimlV---------- 411  Dictyostelium...
5UJ8_A        205 ttssqwqSPP-VVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKE 283  human
XP_001959632  200 -------KPYhLVVILPDFECFSAGVLQDLILILCAHCDELPFVLVLGVATAVSAVHGTLPYHVSSKIRLRVFQTQAAPV 272 
XP_002049232  199 -------RRA-LVIILPDFECFNASVLQDFILILSAQTGRLPFVLVLGVATAMTAVHGTLPYHVSSKIKLRVFQTQPAPT 270 
XP_002068690  201 -------KRQ-LVIILPDFECFSSHVLQDFILILSSHCTALPFVLVLGVATAMTAVHSTLPYQVTSKIRLRVFQTQAAPT 272 
Q0IY07        233 -------DQP-IVVVIDDLEQCSGDVLGELVMMLSEWVIKIPIFFVMGIATTLDAPRKLLSSEDLQRLEPCKLTLGSPSD 304  Japanese rice
Q6E7H0        234 -------ENP-VVIIVDDTERCCGPVLSDLILILSEWAIKVPIFLIMGVSTAHDAPRKILSVNALQRLCATRFTLSSPAE 305  thale cress
XP_001421719  302 -------DCP-VVIVVEDTESFDVRVLDSFIRSVSEFVSSVPVVVLLGLATSVSSLQGMLPAATASLMNAQAFQLWAPGQ 373 
XP_003063429  348 -------PKP-IVVVIEDTEGFDGRVLSDLLLALSDGGDALPVHVLLGVATSAATMHGMIPAAVAAKLAVRSFHLWSPKS 419 
KDE06537      267 -------MRPgLVVMIEDLEGIDATVMTSLFEVLHSCASKVPLTFLIGVATSSDALYHAIPRTCANLLDVTEFFVDLGLS 339 
Q55BR6        412 -------RTP-VILVIEDFETWNSEVLSDLIHLLSAYRHRIPFVLSFSISTSADAIHKVLPYQVVSLLNLKSLHLRSQNE 483  Dictyostelium...
5UJ8_A        284 HLTTVLDKLLLTTQfPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 344  human
XP_001959632  273 GLNEVLEKVLLSPKyAFHLSGKAFKFLTHIFLYYDFSVHGFIQGFKYCLMEHFFAGNAFAL 333 
XP_002049232  271 GLNELLDQVLLSPKyAFHLSGKAFKFLTHIFLYYDFSIHGFIQGFKYCLMEHYFAGNAYAL 331 
XP_002068690  273 GLNEVLDKVLLSPKyAFHLSGKAFKFLTHIFLYYDFSIQGFIQSFKYCLMEHYFAGNAFSL 333 
Q0IY07        305 RMNALVEAILVKPCaGFCISHEVAVFLRNYFFKHDGTITSFISALKLACSKHFSVEPLSFL 365  Japanese rice
Q6E7H0        306 RMDAVLKAVFLKPCsGFTVSHKVALFMRSYFLCQDGTLTSFVRTLKIACLQHFSLEPLSIM 366  thale cress
XP_001421719  374 MMEAVQERVLLSPErVPAFGSEVLNVLHTRFKEHDFSLAAVRRALHLLTITHFMTEPLSAV 434 
XP_003063429  420 IMAAVQERVLLDPAr----------------REHDYSLSAARRAMHLLTLDHFMHRPLSAL 464 
KDE06537      340 AFNGLMTSISLAWDpPVVLGPQIQDTLLHVFDESHHSIDATISAMQLAYAQQFRTQPAAVL 400 
Q55BR6        484 MFEQLVKHLFLKSQ-PYIISKKAYLYLYYNFKNSYMSLSTTISVLRHFIIDHFLENGLSYL 543  Dictyostelium discoideum
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