Conserved Protein Domain Family
Rab5ip

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pfam07019: Rab5ip 
Rab5-interacting protein (Rab5ip)
This family consists of several Rab5-interacting protein (RIP5 or Rab5ip ) sequences. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5.
Statistics
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PSSM-Id: 399778
View PSSM: pfam07019
Aligned: 165 rows
Threshold Bit Score: 30.5821
Threshold Setting Gi: 56470062
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFR02968                27 LANLHSLIAFLLGTAAGILGLQSAYGFTFYLLGTIFVSFLVHgllv----kdntTPraagkstnkgvsgvgAYFPGdgel 102  Nann...
KDE09147              2221 LYYVKSTSASISGATAGVLGLTNTFGFLFYLVTSTLIGSLFLltkg----taegKG----------------YFPGdrv- 2279 Micr...
XP_014569589            25 IYYIKSTMASISGATAGLLGLTNLSGFAFYIMSSMSVAGLVYlitt----eqqpRK----------------YIKGg--- 81   Mixi...
WGS:AAWC:PGTG_13401.3   30 IDSIRSTCSCLSGSLSGIIGLTNFSGLGFYLASFTLVNLTILlvnylrllagysSIlpvknhsvaknlsqnLKFSS---- 105  Pucc...
XP_007417240            33 IEFIKSMTSTISGSLCGILGLTNHLGFLFYLLTSFIVSSLIWfstfik-sksstSSnq-----------slTYFKSs--- 97   Mela...
EEC48737                41 IERIRSVMGIAAGCVAGIGGLTSWEGLICFLILHVFVCVAVWawkm----kfqlQL----------------YTKLs--- 97   Phae...
CRZ24769                39 LEYSRTCQAAASGMASGILGLTGVSGFIFYFVFVVLQALFWEmkan-----fewQN----------------YFTSr--- 94   Brug...
XP_002633223            28 LEFGRTCQSCAAGMAAGILGLTGFQGFILYFISVGIQALIWNvkaq-----gnwLS----------------YFPE---- 82   Caen...
A0CBX9                  25 LKNLRVYGSLNAGMIAGILGMDGWIGMGIYVVVFLIVSACLAik--------mnFRv-------------kEYFKS---- 79   Para...
OWZ02459                24 VEYVHTSMCVIAGCIAGITGMTGLQGFAFLAAAYVFTAVALWifkl----gmdvKV----------------YFNTn--- 80   Phyt...
EFR02968               103 vpvsgggyvrkgaWKDLWFSGLVAteAISGFVLGWA 138  Nannizzia gypsea CBS 118893
KDE09147              2280 -----------saWRTVVLSGLLE--HVFPYILFWT 2302 Microbotryum lychnidis-dioicae p1A1 Lamole
XP_014569589            82 -------------LPELLLSGLLD--NALSFILFWT 102  Mixia osmundae IAM 14324
WGS:AAWC:PGTG_13401.3  106 ---------------AFWGAGLID--NSFGFILWWT 124  Puccinia graminis f. sp. tritici CRL 75-36-700-3
XP_007417240            98 --------------YTLWTSSLID--NLFTFILWWT 117  Melampsora larici-populina 98AG31
EEC48737                98 -------------WFGYLTTSIQP--TALSFTLFWT 118  Phaeodactylum tricornutum CCAP 1055/1
CRZ24769                95 --------------SLSLTHSLIS--GLFTYILFWV 114  Brugia malayi
XP_002633223            83 --------------RNSFTWSHGN--GLLTFVLLWV 102  Caenorhabditis briggsae
A0CBX9                  80 -------------SYDAYYSGIGT--DLLLFLMIWV 100  Paramecium tetraurelia
OWZ02459                81 -------------AFSFIFAGVMS--QALSFILFWT 101  Phytophthora megakarya
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