Conserved Protein Domain Family
EMC6

?
pfam07019: EMC6 (This model is not part of the current CDD release)
EMC6
This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER and for post-translational membrane insertion of tail-anchored (TA) proteins.
Statistics
?
PSSM-Id: 517524
Aligned: 157 rows
Threshold Bit Score: 42.9116
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_003171422  26 ILANLHSLIAFLLGTAAGILGLQSAYGFTFYLLGTIFVSFLVHgLLVKDNTTPraagkstnkgvsgvgaYFPGdgelvpv 105
NP_001236282  35 IIYYSRTFLSIIGGVVAGILGFTGLKGFVFYLLLMAFTSLGLV--------AKakfs---------thtYFDSw------ 91 
CAG1851460    36 SIYYSRTFLSIIGGVIAGIWGFTGFTGFIFYFIVMAAASLSLA--------AKakfs---------vhaYFDSw------ 92 
XP_002456157  28 SINYSRTFLSIISGVVAGIWGFTGLMGFVFYFLVMMVASLMLL--------VKakvs---------vhtYFDSw------ 84 
XP_002441487  26 SVYYSRTFLSIIGGVVAGIWGFTGLTGFVFYFLIMMIASIGLL--------AKskfs---------vqkYFDSw------ 82 
XP_001421223  35 VSARVFTYLSIVSGIAIGALGYTGVRGFAAHGVFMLASACAVAaSKCEGRPTS----------------FFPSv------ 92 
XP_002506669  24 vngvvfQFLAIVAGIVCGCLGLTDLKGFAAFVAANVAIGGAVVa-KCGFKPSK----------------YFVGi------ 80 
XP_003061315  25 vnktiyEFLSVVAGLVCGVLGLTDLGGVLAFLVFNALIGLVVLa-KTGFNLRA----------------HFLSw------ 81 
XP_002682807  27 VVYKCKIFISLVFGIVAGIFGLSGLSGFLFYILVSVVISSVLIglvlpk--------------pfsidgVFTSw------ 86 
XP_005843243  39 VMNFNKIFASLLAGVFAGISGITGYKGFIVYLLAHAIMAGLLLlkasp-----------------hprrFFPSp------ 95 
XP_003171422 106 sgggyvrkgawKDLWFSGLVAteAISGFVLGWA 138
NP_001236282  92 -----------NRVLLDGFLG--GLMSFVLFWT 111
CAG1851460    93 -----------SRILVDGIFG--GLMSFVLFWT 112
XP_002456157  85 -----------NRIIIEGVLG--GLMSFVLFWT 104
XP_002441487  83 -----------TRISIEGVFG--GLMSFVLFWT 102
XP_001421223  93 -----------DKVFLDGPNA--GLPTFVLFWT 112
XP_002506669  81 -----------DKVIVDGASL--GFGTFVLFWT 100
XP_003061315  82 -----------DKVFVEGAAG--GFGTFVLFWT 101
XP_002682807  87 -----------SNIIFGGFTQ--GLLTYILFWT 106
XP_005843243  96 -----------TTLAFSGILSqtEMLTFILFWT 117
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap