7AAV


Conserved Protein Domain Family
MFAP1
?
pfam06991: MFAP1 (This model is not part of the current CDD release)
Microfibril-associated/Pre-mRNA processing
MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesised that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.
Links
?
Statistics
?
PSSM-Id: 517507
Aligned: 97 rows
Threshold Bit Score: 121.131
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
7AAV_K        190 DSEDEM---E---PRLKPVFIRKKDRVTVQErEAEALKQKELEQEAKRMAEERRKYTLKIVEEETKkeleenkRSLAA-- 261  human
XP_002291591  352 A------------TVSKPLFVPKSKRGTVAEvEAQQQKMEEAEERKAKEAERRAFQSRALVAEAVS-------ASGKN-- 410 
XP_002180440  269 EEESSDddgP---VIAKPIFVPKHRRGTLKSaTELEAEDTHQELKQKALEEKRKQESRAMVQQVVA-------ATAQAap 338 
XP_002680980  224 SEEEDI----------RPVFISKNRRSTIKTdQELEEEENRQLELERKRQEQKREKSVKLLDKELE-------NEANR-- 284 
XP_020432661  205 SEEDES---Wg-rPIVMPVFIAKEKRGTIKTdEMYQKEEEDWLVQQEREKEQRKLEAHRKLKEELE-------RDEAE-- 271 
Q54SU3        202 DDEDEY---WdqpPIFRPTFIKKDDRGTIKTdEQWEKEEQEQQAQLEREKEQRKIEAHRKLKDELD-------RDRKE-- 269  Dictyostelium...
ESK98174      148 ESEEEG---Kp-kLQFRPVFVPKRNRITLAErEEMADDTEEAQKRRDAEAEERKKESHDMVAESIR-------RELLE-- 214 
EGN92674      196 SEEEE----Qp-kLLFRPVFVPKRGRVTITEkESITQDSEEVLKQKEIAAEERRKQSHDLVAESIR-------RELAE-- 261 
CCA69164      131 sSEEDE---Pp-rPQLRPVFVSKQQRETLKErDAIAFDSEEAMKKREQAAEERKRQSVNMVGESIK-------RGMEE-- 197 
XP_006960020  111 SSEEEVs-----aPRLKPTFVPKRARETVLQkEKESLDSEEAHKKREKAEEERKQASIDMVADSIR-------RELAE-- 176  Wallemia mell...

7AAV_K        262 -----LDALN--TDDEN-----------DE----------------EEYEAWKVRELKRIKRDREDREALEKEKAEIERM 307  human
XP_002291591  411 -----ASASSglGNEDEfdvgeagsefiPIpddsdpneqdspelvlAERDAWEVRELIRILRDVDEAAEAEKEKKELARR 485 
XP_002180440  339 dfdvaLDGIT--GAQN------------TMpddad------dsddeVARDAWEIREVARLIDELDVEDARLQEERDLSRR 398 
XP_002680980  285 -----KKAVK--IDEDI-----------LSvndsd------didpnGEMMAWIEREMKRLSLIKQ---TRDESDKELQRR 337 
XP_020432661  272 -----QKAAN--KDDDD-----------DDddda--------dedgSRYDAWVQREINRLKKDIRDKLVLEREQSEKLRR 325 
Q54SU3        270 -----QEAKE--LEQKEe---------eEYddde--------dqdgSKKLLWIQRELERVRLEIHTRLLAEFEKKEFARR 325  Dictyostelium...
ESK98174      215 -----KEKEE--EI--------------PDvgdtd------gldpeGEFEAWRLRELARIKKEKEEEIRREQEREEVERR 267 
EGN92674      262 -----KEKED--LI--------------PEiddad------gldptAEFEAWRLRELGRIKKEKEDEVRIEEEREEVERR 314 
CCA69164      198 -----KEAKM--PG--------------QEiddtd------gldpeAEFNLWRMRELMRLKREKEAERAREEERLEIERR 250 
XP_006960020  177 -----KDATD--LI--------------PDvddtd------glepdAEFDAWRLRELKRIQRHKEAQIKRDEEIAEIERR 229  Wallemia mell...

7AAV_K        308 RNLTEEERRAELR-ANGKVIT--------NKAVKGKY--KFLQKYYHRGAFFM---------D----EDEEVYKR----D 359  human
XP_002291591  486 RAMTDEERLDEDR-RMGRYRApgearrrpKDDKSREN--NYLQRYHHRGAFYMdedtlgqagEddvrHRAAEYSR----- 557 
XP_002180440  399 RKMTDEERLAEDI-ATGRYQRp-------GQPKQTDLdqTSAKRYYHRGAYYMdes---ewdSsdvrHKSAVYAR----- 462 
XP_002680980  338 ANNSSFKDSADKEgKSNSQNT-----------EKPKF--KTGQRYYHKGAFFM---------D-----DEEIAEKaa-qV 389 
XP_020432661  326 SKMTDKEIEAEDAeKLAKRDQ-----------PKQKL--KFMQRDYHRGAFFQ---------D-----DEYIKNK----D 374 
Q54SU3        326 RAMTDDQILKEDP-SRSRTNI--------DNSQKKQL--KFLQRDYHRGAFFQ---------D-----DEYIKNK----D 376  Dictyostelium...
ESK98174      268 RALPEAQRLKEDL-EHAQKLR--------DEKPKGQQ--KFLQKYWHKGAFHQ---------------DEEIIKRr---D 318 
EGN92674      315 RALPEEQRLKEDM-ERANKLR--------AEKPKGQQ--KFLQKYWHKGAFHQ---------------VVIYSSRsgkhD 368 
CCA69164      251 RALPEEQRLKEDM-ERAKKLR--------EAKPQGSG--AFLQKYWHKGAFYQ---------------DLDELKNr---D 301 
XP_006960020  230 RAMPEELRLKEDM-ELAKQKR--------EDKYKDRQggTYMQKFWHKGAFHQ---------------DFDVLKR----D 281  Wallemia mell...

7AAV_K        360 FSAPTLEDHFNKTILPKVMQVKNFGRSGR-TKYTHLVDQDT 399  human
XP_002291591  558 --AATGEDKVDKSALPKVMQVKKFGFAGYgTKYKGLAKEDT 596 
XP_002180440  463 --AATGDDKINRAALPEVMRVKKFGFANQnLKYKGLAAEDT 501 
XP_002680980  390 AHAPTGKDHINYDLLPKYYQTKNPGRARQ-PKYTNLKDQDT 429 
XP_020432661  375 FSGATGEDKFNRELLPKIMQVKNFGKGGR-TKYTHLADQDT 414 
Q54SU3        377 FSAPTGEDKFNRELLPKVMQVKNFGKAGR-TKYTHLKDQDT 416  Dictyostelium discoideum
ESK98174      319 YTEATESTM-DVSLLPKVMQVKNFGKRSR-TKYTHLVDQDT 357 
EGN92674      369 FTEGTESTV-DISLLPKVMQVRNFGKRSR-TKYTHLVDQDT 407 
CCA69164      302 YTAPIESQV-DISLLPKVMQVKDFGKRSR-TKYTYLKDQDT 340 
XP_006960020  282 LSGPTMNQV-DLGKLPEVMQVRDFGKTKQ-TKYKTLKDEDT 320  Wallemia mellicola CBS 633.66
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap