Conserved Protein Domain Family
BAALC_N

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pfam06989: BAALC_N 
BAALC N-terminus
This family represents the N-terminal region of the mammalian BAALC proteins. BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organisms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumors or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms. Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.
Statistics
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PSSM-Id: 369161
View PSSM: pfam06989
Aligned: 3 rows
Threshold Bit Score: 74.7453
Threshold Setting Gi: 47224276
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016152332   1 MGCGGSRADAIEPRYYESWTRETESTWLTNTDSESPPQEGSAeGPGREQGG 51  Collared flycatcher
Q8WNE9         1 MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDAPPSNAAP-DSGPEAGG 50  pig
CAG09122       3 MGCGGSRTDALEPLYLESWTKETESTWLTSTDNELPLSSIQ--SSPSEAGl 51  spotted green pufferfish
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