Conserved Protein Domain Family
HET

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pfam06985: HET 
Heterokaryon incompatibility protein (HET)
This family represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains. Many family members also contain the pfam00400 repeat and the pfam05729 domain.
Statistics
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PSSM-Id: 369159
View PSSM: pfam06985
Aligned: 99 rows
Threshold Bit Score: 107.073
Threshold Setting Gi: 74615980
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EAA27268     164 YSALSYEWglppKDES---------------------N-SPTILLGG----------HTVRVRENLYNALRRI-RDvqlk 210 Neurospora cras...
Q2GUT3       229 YVVLSYTW----GDPTtmppdewarikgagtktingrPvPERL--NPf---------QLWDLPETMQDAVMISgS----- 288 Chaetomium glob...
Q7RV26       260 YVVLSYSW----GDPTtmpaeewar---ikgastktvD--------GvpapertnpfPRSILPETMRDAIAIT-QE---- 319 Neurospora crassa
EAA26645     352 YLTLSHCW----GPPEkrpattt--------kanltqR-MERIPF--------------IELPRTFRDAIEIT-RK---- 399 Neurospora cras...
EGZ70405      34 YITLSYRW----TAETpktn--------------lktH--------Nkdky--hqsiPTENWPQIYKDAVALS-RT---- 80  Neurospora tetr...
Q7SCF8       257 YNTLSYQW----TADTskts--------------lrkH--------Nraay--chaiPTEAWPKVYKDVVIVC-RA---- 303 Neurospora crassa
XP_001593851 130 YATLSHRW----GNSHfiqtnr----------qtlqkHiKTGIEI--------------CDLPKTFADVVTIL-RT---- 176 Sclerotinia scl...
Q0UB49       164 YVALSYCW----GSSEqsktlk----------nnvgvRk-GRIPV--------------TELPRTLQDSIRMT-QA---- 209 Parastagonospor...
Q2U074       201 YACLSYCW----GIDIdrvmktt--------tdnihsHy-QRLEL--------------AQLPAAIQDAIAVC-RA---- 248 Aspergillus oryzae
Q2U8M5       222 WVALSYCG----GADSsitlns---------ssfenlRsGQPL----------------SDFPLTLRDAVLVT-RA---- 267 Aspergillus oryzae
EAA27268     211 insntDSPLLLWVDAVCINQDDDV-EKGHQVQMMGQIYATAQMVFVWLGSGSE-QT-LAAMNAINAVGMENLKEl-Ednl 286 Neurospora cras...
Q2GUT3       289 -----LGVFYIWIDNVCIPKGT---NWDTEASLMHEVYGNSAFTLVASSSSKAtDR-LIHDRLAWTHRSKACQLreMwwl 359 Chaetomium glob...
Q7RV26       320 -----LNFKYIWIDNVCIPKG--T-DWDTEASLMHEVYGNAAFTLLASSSTKA-TE-PMLYDRLAWLQEPKPCKl-Rnhf 388 Neurospora crassa
EAA26645     400 -----LGHRYLWIDSLCIIQDDEQ-DWAYEAALMAKIYSHAFCMLSALSSNDS-SE-GLRLEPLDEDSSYMDLMt-Tsha 470 Neurospora cras...
EGZ70405      81 -----LGIRYVWIDSLCIIQDDGK-DWNTQASLMHRIYTHGYLNLAHACAEFS--PgLEVTRDPISVSPCVLSRt-Rtas 151 Neurospora tetr...
Q7SCF8       304 -----LGVRYVWIDSLCIVQDDLE-DWKVQSSMMQDVYSHGHLNLANVLGKHA-DG-LEVSRYPTATSPCILSRtlEdgs 375 Neurospora crassa
XP_001593851 177 -----LRIRYVWIDSLCIIQH-DDeDWKEQATQMARIYFKGYLNIAATAASDS-TEgCLNTRSLRHGIISDLRAlpInas 249 Sclerotinia scl...
Q0UB49       210 -----LGIQYLWIDSLCIIQD-DEhDWALESSKMADIYSNAWLVLAATGAPDC-ASgMLEIREPPFVIPPNQLLgtTaci 282 Parastagonospor...
Q2U074       249 -----LKIPNLWVDSLCIIQD-DKvAWLHDASTMHDVYHNSHLTIAVMEPNSC-KLrFLGKQQFG-----DHSWqrLfcp 316 Aspergillus oryzae
Q2U8M5       268 -----LGVRYLWIDCLCIFQD-DTnDMAAEASRRSRVYSNAVVTIAATTAETV-NDgFLDKREPHFNCSFPWRRhdHlds 340 Aspergillus oryzae
EAA27268     287 rkngdhildidtlcesledsghnrpedefdklwvanlpteqqewvnklrnvsRGIAEFCE------ASYWRRVWIVQE 358 Neurospora crassa...
Q2GUT3       360 q-----------------------------------------------ntqtPLDRVRFE------APVSMRAWTLQE 384 Chaetomium globos...
Q7RV26       389 ly----------------------------------------------ntqkPLHEVRLD------PPASQRAWTLQE 414 Neurospora crassa
EAA26645     471 spaggsgiiksdmdes------------------fiwfrisihleawgiiygGTSYHDTI------SPLCTRAWTLQE 524 Neurospora crassa...
EGZ70405     152 skey-----------------------------------------wacfrnyTPSSDLAR------APLYSRGWCYQE 182 Neurospora tetras...
Q7SCF8       376 tehw------------------------------------------gcmedgSWREHIQD------APLYTRGWCYQE 405 Neurospora crassa
XP_001593851 250 nvshennvvyi----------------------------rpsfhavhqrfniRKRNRETDpadheiTSLLSRAWIFQE 299 Sclerotinia scler...
Q0UB49       283 svrr------------------------------------------tvthdsTGTRSVIS------QPLWKRAWAMQE 312 Parastagonospora ...
Q2U074       317 tlpdlpedt--------------------------------stellmrpgkfKPRSDTER------SSLDKRGWCLQE 356 Aspergillus oryzae
Q2U8M5       341 vkndcrty----------------------------------pvffrgdrspLNKERPRD------SPWATRGWTLQE 378 Aspergillus oryzae
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