Conserved Protein Domain Family
HemN_C
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pfam06969: HemN_C 
HemN C-terminal domain
Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyzes the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX, one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain (pfam04055) suggest it may be a substrate binding domain.
Links
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Statistics
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PSSM-Id: 488676
Aligned: 41 rows
Threshold Bit Score: 44.936
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_011985443 363 VTADDVMRRFVINRVMCLLKLDLREVAEKFGPAARKTIEAdlakgveELQGDGL-VTFDGELLRVTPLGQLL 433 Anaeromyxobacter sp. Fw...
WP_011927882 307 VPKTEQAFEVMMNGLRLRAGFPTAFLAQRSDLDLSDLMPTl-----lPLIDRGLiDADIAECIVTTPRGFSL 373 Dichelobacter nodosus
WP_011711755 311 LTPQEAGNEALVMGLRMGEGMSKATYQWVRGVSLQQSVGDgl----aWFERQGM-LAQSATHVWLTPRGLRL 377 Magnetococcus marinus
Q0VLC0       316 IAREDRLFEALLNGLRLTHGLCWQTLEDATGEPVAQWRHQl-----tPFEQQGL-LTLTDQRLACTDNGLRH 381 Alcanivorax borkumensis...
Q9I6A9       309 LEAADLPFEFMMNVLRLVDGVPAALYPQRTGQPLAAIADAc-----aAARDAGL-LADDPQHLRPSERGQLF 374 Pseudomonas aeruginosa
P43899       306 VPKIDRPFEFFMNRFRLLEAVPKQEFEDYTGLSQSAVKNQi-----dFAIQQNY-IVENADSWQITEHGKLF 371 Haemophilus influenzae ...
Q5ZT11       300 ITGKELLFEFMLNTTRLEQSIPLDLFTTTTGLELNQLLPLl-----kLANKKQL-INLTDTHWQVTPLGRQY 365 Legionella pneumophila ...
Q7UKX5       310 ITLEQYARELAAFGVRQLDGIDLSTIDNRTSIDLETLLAKtl----tKLQSMEL-VTHENHHLRLTCRGILF 376 Pirellula sp.
EEC11362     326 LTHQEIIEEMLMMGLRLSKGINISTLEQKLNTKLENILDMnn---lkHYQSQDL-IKLDKN-IYLTDKGLML 392
Q8F348       311 YTKPNFYEELILSLFRLFQPILMESFYELIPDQSQTLDLQl-----kKFQESGL-CEFSNGIFQWKPEAVLF 376 Leptospira interrogans
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