4JXC,4RTB


Conserved Protein Domain Family
BATS

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pfam06968: BATS 
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Biotin and Thiamin Synthesis associated domain
Biotin synthase (BioB), EC:2.8.1.6, catalyzes the last step of the biotin biosynthetic pathway. The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer. Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this family) and form a heterodimer. Both of these reactions are thought of involve the binding of co-factors, and both function as dimers. This domain therefore may be involved in co-factor binding or dimerization (Finn, RD personal observation).
Statistics
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PSSM-Id: 399745
Aligned: 726 rows
Threshold Bit Score: 38.9914
Threshold Setting Gi: 301637076
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4JXC_A              230 FIPH----------PDTPLanekkgdftltLKMVALTRILLPDSNipattamgtIVPGGRE-------ITlRCGANVIMP 292 Thermoto...
Q58195              264 FNPY----------KGTPMenhpkcsaleqAKTIAITRLIFPNIR---------ITSPTPTigaelvqFAlFGGASNVAT 324 Methanoc...
MA:Minf_2024        250 LRPAaggftppypmEDRDL-----------FHFLCAFRITFPQVG---------IVLSTREqphfrekLI-PFGITAMSA 308 Methylac...
CAR45488            262 LRPCagglnpasvmSEAEL-----------VQLICAFRILAPDVE---------LSLSTREspyfrdnTV-PLAINNISA 320 Proteus ...
WP_015699038        262 LRPCtggiepasllEENQL-----------VQLICAFRMLAPDVE---------LSLSTREspyfrdhVI-PLAINTVSA 320 Rahnella...
CCH:MU9_696         264 LRPCaggiepeslmNETEL-----------VQLICAFRLFAPDIE---------LSLSTREspyfrdhMV-PVAINQVSA 322 Morganel...
goetting:EBL_c37180 262 LRPCaggvqpaslmDERQL-----------LQVICAFRIMSPDVE---------LSLSTREspwfrdhVV-PLVINHVSA 320 Shimwell...
WP_025424012        262 LRPCaggvtpaslmDEAQL-----------LQVMCAFRLLAPEVE---------ISLSTREsahfrdhAV-PIVVNSVSA 320 Sodalis ...
Q8D250              262 LRPCtngispkciiNESDL-----------LQIMCVFRILFPEIE---------ISLSTREskkfrdnIS-PILINNISA 320 Wigglesw...
EHQ42251            260 LRPAegnvepnfvmEDIDL-----------LQLMFAYRIWNEDIE---------LSISTREsewfrdhVI-GLGVTSMSA 318 Myroides...
4JXC_A              293 -----------NWTpspy-------------------------------rqlYQLYPGKIcvFEKDtacipcvMKMIELL 330 Thermoto...
Q58195              325 vipknhpmnvkGV------------------------------------------GNPKTgnLEEV-------VKMIMDL 355 Methanoc...
MA:Minf_2024        309 -----------GSKtepggytdagthslhrrlkgkeirldenekngakateqFEISDRRS--PDQI-------AALLKSM 368 Methylac...
CAR45488            321 -----------GSKtqpggysd-----------------------sheeleqFSPNDNRH--VSDV-------INALKTR 357 Proteus ...
WP_015699038        321 -----------GSKtqpggyad-----------------------dhpeleqFSPHDNRS--PQHV-------ANALTRA 357 Rahnella...
CCH:MU9_696         323 -----------GSRtqpggyae----------------------eddpeleqFSPHDNRS--PQQV-------ADALLAA 360 Morganel...
goetting:EBL_c37180 321 -----------FSRtqpggyad----------------------gdapeleqFAPHDGRT--PDEV-------AQMLVAA 358 Shimwell...
WP_025424012        321 -----------GSKtqpggyas-----------------------drpeleqFLPHDNRS--PQEV-------AQVLTRA 357 Sodalis ...
Q8D250              321 -----------GSStqpggyst-----------------------skkelnqFEIQDNRS--PREV-------SQELEKK 357 Wigglesw...
EHQ42251            319 -----------GSKtnpggysv-----------------------dqgslaqFETCDQRS--TAAI-------YQLIQSK 355 Myroides...
4JXC_A              331 G 331 Thermotoga maritima MSB8
Q58195              356 G 356 Methanocaldococcus jannaschii DSM 2661
MA:Minf_2024        369 G 369 Methylacidiphilum infernorum V4
CAR45488            358 G 358 Proteus mirabilis HI4320
WP_015699038        358 G 358 Rahnella aquatilis
CCH:MU9_696         361 G 361 Morganella morganii subsp. morganii KT
goetting:EBL_c37180 359 G 359 Shimwellia blattae DSM 4481 = NBRC 105725
WP_025424012        358 G 358 Sodalis praecaptivus
Q8D250              358 G 358 Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis
EHQ42251            356 G 356 Myroides odoratus DSM 2801
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