6W4S


Conserved Protein Domain Family
FPN1

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pfam06963: FPN1 (This model is not part of the current CDD release)
Ferroportin1 (FPN1)
This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell. This family may represent a number of transmembrane regions in Ferroportin1.
Statistics
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PSSM-Id: 517492
Aligned: 17 rows
Threshold Bit Score: 428.643
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6W4S_F        22 TSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGnSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLK--VAQTSLVVQ 99  human
Q8W4E7       146 PEGLYVLYASCLVGNLVEQLWNFAWPSAIAMLYP-SLLPVAVMGFVTKLAIIAGGPVVGKFMDYSPRVP--TYISLNVIQ 222 thale cress
XP_011387882  82 ARGTLLLAVQHATLSWGYRSAEFAYPLMMVQLFTnTLLPASIYGFVTTAGAILFSNNVGRLIDTYAHLKlrTLRAMILSQ 161
Q5AXY5        19 NRVLLRLYTSHFLSTWNSRMFEFGAVVFLASIFPgTLLYASVYALVRSLFAVLFSSWLGSLVDRTDRLS--AIRHSIIWQ 96  Aspergillus nid...
Q0CWF0        44 KHVLFRLYVSHTLSTWNSRMFEFGSVLFLASIFPgTLLYASIYALGRSLSAVLLSSWLGSMVDRSNRLT--TIRHSII-- 119 Aspergillus ter...
1_pfamImport   1 TRILFRLYISHFLSTWNSRMFEFGAVLFLATIFPgTLRYTSVYALVRSLSAVVLSSWLGSVVDRANRLR--AIRHSIIWQ 78 
XP_001274573  39 KHVLARLYVSHFLSTWNSRMFEFGAILFLASIFQdTLLYASVYALARSLSAVVLSSWLGSRMDHSDRLV--TIRRSIIWQ 116
Q9I9R3        19 KSAKFLIYVGHALSTWGDRMWNFAVAVFLVELYGnSLLLTAVYGLVVAGSVLLLGAIIGDWVDKNPRLK--VAQTSLVVQ 96  zebrafish
Q8IA95         5 SGKELQLNSAFLLTTLGDRMWAFVIGLFMHQLg--GMTWVAVQQLVDSVLKLVVITIVGQYLDKIDRSK--IIQRTLLLN 80  Caenorhabditis ...
XP_002647495  13 SKASIFLYCAYISTCLEDRAWSFCVSLCMDLLg--GMRVVSIEQLFEGVLQMVLSGYLGKHFDGLSRKR--AIMTVVPLN 88 
6W4S_F       100 NVSVILCGIILMMVFLHKHELLTmy----------hGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVA-GEDRS 168 human
Q8W4E7       223 AAAQVLSAGMIIHAYTVPSTSAS-------------SILLQPWFFALLFAGAIDSLCGIASGVAIERDWVVLLAgINRPI 289 thale cress
XP_011387882 162 KLLVGASYGLFLILFSSTSLRMEaenggkgpqdaraNARPWVFFAAITLLGIGVMLSNVGVSVGVEREWVTIIS-DGSSA 240
Q5AXY5        97 RIPVAVSCVCLGLLLRSPP-----------------GHLSRLLFIALVLLAGVEKLAATVNTVSVERDWAVVIS-ETLLV 158 Aspergillus nid...
Q0CWF0       120 ----AASCACFVHLLNRSSEL---------------TYFSPLLFTAIALLACVEKLAANVNTVSVERDWAVVIS-DALQY 179 Aspergillus ter...
1_pfamImport  79 RIPVAASCACFTVLLAPTT-----------------TAITSLVFAGTVLLACVEKLAATANCVAVERDWAIVVS-DALDI 140
XP_001274573 117 RLPVVLSCACFVVLLVPSLMGN--------------KFVTWGLFAAVLLLACVEKLAAIANTVAVERDWAIIVS-DSLAI 181
Q9I9R3        97 NSAVILCGALLMAVFQFKQQLSSmy----------dGWLLTTCYIMVISIANIANLASTAMSITIQRDWVVVVA-GDDRS 165 zebrafish
Q8IA95        81 NAAVAVSAGLFAYMFVHKT-----------------DHYATPVLLMASAVASIAKVASEIQRISFTKDWVVVIS-QSESV 142 Caenorhabditis ...
XP_002647495  89 NLSICAAAALIITCLSMDTT----------------SPWYIVCLVVAMCMCAVNRLFLNSEKFITGRDWVMVLG---NDG 149
6W4S_F       169 KLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEeETELKQ 248 human
Q8W4E7       290 ALAQANAVLHRIDLLCEIAGTMLFGILLSKYDPVTCLKFAATLMVGSLPTMTALIWLTNKFSSGVLDRPKCSLnSCSAEG 369 thale cress
XP_011387882 241 RLTRLNAIMRRIDLISKLVSPLFVSALTSTMGYTLAAVVLFSVNAVTGIFELIFVGTVYRRFPSLANDEKVAIaRRQTAA 320
Q5AXY5       159 SRKDLNASMRRIDLFCKLVAPVVVSLMDGLLSTKVAIWAVLGVNVTVVLVEYFAIAGVYHSVPQLDRSHERQAaDDEEDE 238 Aspergillus nid...
Q0CWF0       180 SRQGLNASMRRIDLICKLLAPVVISFLDG-FSTRAAIWTVLGVNVSCVVVEYIAIAQVYKVVPELERHRDASEnEEDGAN 258 Aspergillus ter...
1_pfamImport 141 PRQDLNASMRRIDLFCKLLAPVVISVIDG-LSTKIAIWTVLVVNVSCVVLEYIAIAQVYTSIPELKRCQDESSeIGDGPG 219
XP_001274573 182 QRQDLNASMRQIDLFCKLLAPLMVSLIDS-LSTSIAVWLVLAVNILCVFVEYVAIAQVYEAIPELRRVQRGLAtNDGENG 260
Q9I9R3       166 KLADMNATVRIIDQLTNILAPMLVGQIMAFGSHFIGCGFISGWNLFSMCLEYFLLWKVYQKTPALAFKAGQKDsDDQELK 245 zebrafish
Q8IA95       143 DLAKVNSILLCIDQISSAILPTLTGELLDTFKWQYVCGFIIVYNLASWVIESMILRRLYNETPQLKTRASEITgDEE--- 219 Caenorhabditis ...
XP_002647495 150 TLSSMNATLLTLDQFTNVIAPLVTGALVTWVGLRETVGIFGIASLLSMTSKSIFLRMIYISNPLLQVKKDKKEyIDPFAN 229
6W4S_F       249 lnlhkdtepkplegthlmgvkdsniHele----------------------heqEPTCASQMAEPFRTFRDGWVSYYNQP 306 human
Q8W4E7       370 -------------------------S----------------------------RTNTDSIFDIGMETIKLGWKEYIQQP 396 thale cress
XP_011387882 321 -------------------------Eastdssacrepsl---saqgtkarlaklTSLLVASVVEDVKQQYHDWKLFVRLP 372
Q5AXY5       239 -------------------------Qqp------------------------leEHLAQNIFAQYIRRTVAPWREYVGQS 269 Aspergillus nid...
Q0CWF0       259 -------------------------Hvqd----------------------snsHRAGIYSVVRYIHRAVAPWKEYVSSR 291 Aspergillus ter...
1_pfamImport 220 -------------------------Lepqd---------------------ggsAPTAARRIAQYSRKALAPWREYVASS 253
XP_001274573 261 -------------------------Eddfqp------------------tsravQRSVVNRAARLLNHVAAPWREYIASP 297
Q9I9R3       246 -------------------------HlniqkeigntespveasqlmtessetkkDTGCCYQMAEPIRTFKDGWVAYYNQS 300 zebrafish
Q8IA95       220 -------------------------------------------------------LRGLKGVKLNSITQ------YFKQQ 238 Caenorhabditis ...
XP_002647495 230 -------------------------S----------------------------------RLKESVVYT------YWRQV 244
6W4S_F       307 VFLAGMGLAFLYMT-VLGFDCITTGYAYTQ-GLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCL 384 human
Q8W4E7       397 VLPASLAYVLLYFNiVLTPGSLMTAFLTQR-CVNPSVIGGFSGLCAVMGVAATFLSANLVKRVGILKAGAVGLFFQASLL 475 thale cress
XP_011387882 373 IFLTSLCISLLYMS-VLSFDPTFIAYLKSEtLYSDAFIAGMRAVGVVTGLMGTFAMPLLEKRIGLVRTGSYSLFAELIPL 451
Q5AXY5       270 VFLASFALSLLYLT-VLSFGPTMVTFLLHS-GFSSLDVSAMRIGAVLTEISGTWMAPLLMDRIGPIRSGLWFLNWQFGTL 347 Aspergillus nid...
Q0CWF0       292 VFLASFSLSLLYLT-VLSFGTTMVTYLLHT-GFSALEVSCMRIGAVVAELSGTWAAPIVMNRIGPIRSGLWFLNWQFGCL 369 Aspergillus ter...
1_pfamImport 254 VFLASLALSLLYLT-VLSFGTTMVTYLLHT-GFTPLQVSGMRIGAVIAELSGTWAAPFITGRIGPIRSGLWFLNWQFACL 331
XP_001274573 298 VFLASFSLSLLYLT-VLSFGPTMVTFLLHT-EYTSLQVSCMRVGSVIAELSGTWVAPFVMDKVGPIRSGLWFLNWQFTCL 375
Q9I9R3       301 IFFAGMSLAFLYMT-VLGFDCITTGYAYTQ-GLNGSVLSLLMGASAVSGICGTVAFTWIRKKCGLIRTGFIAGVTQLSCL 378 zebrafish
Q8IA95       239 SWTAGFGLSLLYMT-VLGFDNLAASYGQKH-GLSASYIGVLRGFGSALGVIGTFSFQFVAKRFGLLWTVMIGLVWQNIFI 316 Caenorhabditis ...
XP_002647495 245 SFPAAFGMSLLFMT-VMGFDGLAVGYGTSA-GLPEFVVGAFRSYGSATAILGAFSYAFFEKQYSVATSGLLGLGVQQLFA 322
6W4S_F       385 ILCVISVFMPGSPldlsvspfedirsrfiqgesitptkipeitteiymsngsnsanivpetspesvPIISVSLLFAGVIA 464 human
Q8W4E7       476 AVAVAVYCSSSLS-----------------------------------------------------HKSPLFFFLSMIVL 502 thale cress
XP_011387882 452 VPAVVSLWITGSPsdrfgl------------------------------------------sdkrrSNWNTGLLFSGLAL 489
Q5AXY5       348 AAAVAAFAFASDR-----------------------------------------------------PRLVAGCLITGVAL 374 Aspergillus nid...
Q0CWF0       370 AAAVAGFAFLERN-----------------------------------------------------SQVVAVSLIVGVAL 396 Aspergillus ter...
1_pfamImport 332 AAAVAAFAFLDNQ-----------------------------------------------------SQVVAVSLIVGVAL 358
XP_001274573 376 SAVAAAFALTDAT-----------------------------------------------------SRLVLVGLIVGVAL 402
Q9I9R3       379 TLCVASVFAPGSPfdlsvspfeevlrhlfgdsgslres---ptfiptteppiqanvtvfeeappveSYMSVGLLFAGVIA 455 zebrafish
Q8IA95       317 EMCGVSVLLPGSSmdvsgyiantsvsewskev---------------lsrvsnpepqnvpsvsfydVALPVNLFFIGISF 381 Caenorhabditis ...
XP_002647495 323 ILAVISVFLPGSPmnldgyfgnftvgtwwhdlvhsf--------ngnnatnldphvdwkhfssdgvSLASIFVFLIAIAS 394
6W4S_F       465 ARIGLWSFDLTVTQLLQE-------NVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFV 531 human
Q8W4E7       503 SRLGHMSYGVVGAQILQT-------GIPSSKANLIGATEISVASLAESLMLGVAIAANDASHFGFLAVLSLLSV 569 thale cress
XP_011387882 490 SRIGLWAFDLTQLAMIQTalspeqlGPDAGRKNALMALQFSLQNVFDLGHYGLTLGWNKPQEFKYAATVSLVAV 563
Q5AXY5       375 SRLGLWGFDLSVQFLVQE-------NIDPSSRARFSATEMALQSVFEMISFATTIFFADPDQFKYPVYISYGAI 441 Aspergillus nidulans
Q0CWF0       397 SRIGLWGFDLSVQFLIQD-------GIAEHERARFSSTEMALQNIFELLSFATTIVFSRPEQFKYPVFISYGAI 463 Aspergillus terreus N...
1_pfamImport 359 SRIGLWGFDLSVQFLVQE-------GVDERARARFSSTEMALQNIFELLSFATTIAFPLPEQFKYPVFISYGGI 425
XP_001274573 403 SRVGLWGFHLSAQFLIQE-------GVEEETRGQFSSTEMAVQNIFEMLSFATTIAFPLPEQFKYPVFISYGAI 469
Q9I9R3       456 ARVGLWSFDLTVTQLIQE-------NVIESERGVINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVIISVSFV 522 zebrafish
Q8IA95       382 ARFGLWLADPAITQIQQE-------TIPESQRYMAFTVQIALNEVFSILKDIIVIMFPFTPLFGVLTLGSCVFV 448 Caenorhabditis elegans
XP_002647495 395 ARYGLWCLDLAITHIMQV-------TIPERERNTVFGMHNALCQTFSVLKDVLVIILPLPATFAICIFISYGFV 461
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