5A1U


Conserved Protein Domain Family
COPI_C

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pfam06957: COPI_C (This model is not part of the current CDD release)
Coatomer (COPI) alpha subunit C-terminus
This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport. Note that many family members also contain the pfam04053 domain.
Statistics
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PSSM-Id: 517488
Aligned: 27 rows
Threshold Bit Score: 517.612
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5A1U_C        816 GFFEGSIASKGKGGalAADIDIDt------VGTEGWGEDAELQLDEd----------gFVEAPEGLGEDVLg----KGQE 875  house mouse
XP_004238316  816 GIFEGGLDSTVRGG--H--EEYEe------AADADWG--ESLDIGEve--------nlQNGDISMVLDDEEgk-eeND-- 872 
3_pfamImport    2 GIFEGGLESAARGG--AVDEEEEe------DAGGDWG--DALDMVDvd--------gmENRDIEAILAEAEgaeedND-- 61  
Q94A40        816 GIFEGGLESADRGG--TVDEEDV---------EGDWG--EELDI-Nvd--------gmENRDIEDILAAAEageeeND-- 871  thale cress
Q9AUR8        816 GIFEGGLDATGKAE--L--EEDDe------AAGADWG-DEDLDMVDase-------amANGGDGFDAEEGEaneedG--- 874  Japanese rice
ERN04739      604 GIFEGGLEN--RGK--TAHEGEEe------AADANWG--EDLEIIEme---------gPNGDLE-IIGDEEviedgDG-- 659 
XP_001417203  815 GFFEGVLSGEIAGD--EYAEDDVmg---mgGVGLGWG-DADIDIGDderv-----dplAKAGIAPDVEFD------DVDN 877 
XP_003057643  821 GFFEGVLSGEVDAS--AYAEGGFd-----dEAGAGWGDDLDIDLGGdddkek-eedplAAAGLAAGSDEEKeggdgSD-- 890 
XP_002501894  821 GFFEGVLAGDISAS--DYVMEEGe------DAGAGWGDDLDLDLGGdegakekeedplAGLGLG---DDDEregdgEDDG 889 
XP_004360289  812 GGQDRKFAMDNSG---AVDDDDEidnsgpkIGGGGWGDDDDIMAED------------NNKNKGDEQQDS---------- 866 
5A1U_C        876 EGGGWDv-EeDLEL----------PPELDVPSGVSgs---aeDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMR 941  house mouse
XP_004238316  873 EEGGWDl-E-DLDL----------PPDTDTPKTASna----rSSVFVTPNPGMPVSQIWVQKSSLAAEHAAAGNFDTAMR 936 
3_pfamImport   62 EEGGWGelE-GLDL----------PPELDTPKASAna----rSSVFVTPTQGMPVSHIWSQKSSLAAEQAAAGSFDTAMR 126 
Q94A40        872 EEGGWGl-E-DLVL----------PPELDTPKASAna----rSSVFVTPPQGMPVSQSWSQKSSLAAEQAAAGSFDTAMR 935  thale cress
Q9AUR8        875 EEGGWDl-E-DLEL----------PPEAETPKNAGna----rSAVFVAPPPGMPVSLIWTQKSSLAGEHAAAGNFDTAMR 938  Japanese rice
ERN04739      660 EEGGWDl-E-DLEL----------PPELAAAANIAgir--lsNSSFVAPTPGMPVSQIWTQKSSLAGEHAAAGNFDTAMR 725 
XP_001417203  878 ENDGWGm-D-ELEL----------PEELMGGAVDDtgaetfhSDVFIAPTAGVPPSRRWTEKSAVAGEHVAAGDFDSAMK 945 
XP_003057643  891 SDAGWDm-E-DLDL----------PPDVGGGDDDGglv--gpSEVFVAPTAGIPPSRRWTEKSAVPGEHAAAGDFDAAMK 956 
XP_002501894  890 SDAGWDm-E-DLEL----------PADLGAGADDGada--gvSEVFVAPTAGVPVARRWTQKSAIPGEHAAAGDFDSAMK 955 
XP_004360289  867 NGGGWD--D-DIVIeggkgdgsgwDDDIDIGTSVSkq---diSSMFVPPQPGSSFGQIWSRNTNFAVDHIAAGSFETAMN 940 
5A1U_C        942 LLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYSYPNRNWKDAGLKN--GVPAVGLKLNDLIQRLQL-CYQLTT 1018 house mouse
XP_004238316  937 LLSRQLGIKNFSPLKQLFADLHMGSHTYLRAFSSAPVISLAIERGWSESASPNvrGPPALIFNFSQLEEKLKT-AYRATT 1015
3_pfamImport  127 LLNRQLGIKNFAPLKSMFIDLFSGSQSYLRAFSSSPVVPLAIERGWSESNSPNvrGPPALLYGFSQQEEKLKS-GYKATT 205 
Q94A40        936 LLHRQLGIKNFTPLKSMFLDLFNGSHSYLRAFSSCPVVPLAIERGWSESSSPNvrSPPALVYDFSQLDEKLKS-GYKATT 1014 thale cress
Q9AUR8        939 LLSRQLGIKNFAPLKPLFVDLHMGSHSYLRALATAPIIPIAVEKGWSESASPNvrGPPALVFTFPQMEDRLKA-AYKATT 1017 Japanese rice
ERN04739      726 LLSRQLGIRNFAPLKPLFMDLYLGSHAYLRGFPSAPLVPLAVERGWNEQGSANvrGPPAMVSKLSFLEERLKL-AYKATT 804 
XP_001417203  946 LLSRQLGIVNFAPLKQHFVDLAYASHVTLEGMPASPKIPMPLGRGWSSRATGV--LPPAMICSPEILQERLKS-AFKLTT 1022
XP_003057643  957 LLNRQLGVINFAPLKQHFIDAAFATHASMTATSMGPNLTFPLGRDWNADAPVGktPQPALVSSLAVLEAKLKA-AYKTTT 1035
XP_002501894  956 LLNRQLGVVNFAPLRQHFIDAALATHAAMSGVTSAPSLSFPLGRNWNSDLAPGvgCAPALVSSLPLLEDRLKL-AYKTTT 1034
XP_004360289  941 MLNQQVGIVNFEPVRSFFINIHMGARVALSSQAALQPIIEPLQRKH---------GQPYVSYNIQHLLERLRTlAYKSTT 1011
5A1U_C       1019 VG---KFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLCMEIERKKLPketlDQQ-KRICEMAAYFTHS 1094 house mouse
XP_004238316 1016 SG---KFSDALRLFLSILHTIPLIVVESRREVDEVKELIVIVKEYVLGLQMEVKRKESK----DNP-VRQQELAAYFTHC 1087
3_pfamImport  206 SGkdeKLTEALRLFLSILHTIPLVVVESRSEVDEVKELVSIAKEYVVGLKMELKRRQKK----DDP-VRQQELAAYFTHC 280 
Q94A40       1015 TG---KFTEALRLFLSILHTIPLVVVETRREVDEVKELIVIVKEYVLGLQMELKRREMK----DDP-VRQQELAAYFTHC 1086 thale cress
Q9AUR8       1018 DG---KFPEALRQFLSILHTIPLIVVDSRREVDEVKELIEIVREYVLGLRMELKRKELR----DDV-NRQQELAAYFTNC 1089 Japanese rice
ERN04739      805 EG---KFAEALKLFLNILHLIPIIVVDSRREVDEVKELVVIAKEYVLALQMEVKRKELK----DDP-VRQQELAAYFTHC 876 
XP_001417203 1023 EG---KFVEALKVFVGIIHAITLLSVEDPSEVEDVEQLLKVAREYACALRIEIARKEVK----DDA-TRQAELAAYFTHS 1094
XP_003057643 1036 EG---KFGEALKLFQSIIHGVAVLLVDSRREVDEVRELLGIAREYAVALRIEMKRKEHK----EDP-VRAAELAAYFTHS 1107
XP_002501894 1035 EG---KFGEALKMFQGIIHSIAVLLVETRREVDEVRELLGIAREYASALRIEIKRKEYK----DDP-KRAAELAAYFTHC 1106
XP_004360289 1012 EG---KFTDAILHFTYILHCAIFTTVESKQEFNEIKELIGVCREYITGLRIETQRKELP----PTQlTRVAELAAYFTHC 1084
5A1U_C       1095 NLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPK-PEVAQQTRKILSACEKNPTD-ACQLNYDMHNPFDICAAS 1172 house mouse
XP_004238316 1088 NLQLPHLRLALQNAMSICYKASNLSSAANFARRLLETNPTnESQAKTARQVLQAAEKNMRD-ATELNYDFRNPFVVCGAT 1166
3_pfamImport  281 NLQLPHLRLALLNAMTVCYKAKNLATAYNFAKRLLETNPL-ESHARAARQIVKAAERNMTD-TTELNYDFRNPFVICGST 358 
Q94A40       1087 NLQTPHLRLALLSAMGVCYKAKNLATASNFARRLLETSPV-DSQAKMARQVVQAAERNMTD-ETKLNYDFRNPFVVCGST 1164 thale cress
Q9AUR8       1090 KLQRVHMRLVLGSAMGLCYKQKNFATAEHFARMLLENNPN-EAQARRARQVQQQCS-GKKD-SSELNYDYRNPFVVCGAT 1166 Japanese rice
ERN04739      877 NLQKVHLRLALMNAMGVCFKGNNYNTAANFARRLLETDPP-SNQASKARQVLQICERNPKD-ASQLNYDFRNPFILCGLT 954 
XP_001417203 1095 EMQPIHLSLSLRSAMSIFFKLKNYVTAATFCRRLLELNPP-VKVATQAKQVLQACERAPKD-EVEVNYDPHNPFAVCSAT 1172
XP_003057643 1108 MMQPIHASLALRSAMSLFFKLKNFNTAANFCRRLLELNPP-VKVAQQAKQVLQACERTPTD-EVELDYDSRNPFVVCSAT 1185
XP_002501894 1107 AMQPIHLSLSLRSAMSIFFKLKNFNTAAEFSRRLLELSPP-VKVAQQAKQVLQACERENKD-EVELDYDSRNPFVVCAAT 1184
XP_004360289 1085 NLEPTHLVLALRSAMNNAYKLKHFDLSASFARRLLDLSPP-GDLSTQAKKVIAFSQQNQTDpSITIAYDERNPFVIDSLS 1163
5A1U_C       1173 YRPIYRGKPVEKCPLSGACYSPE--FKGQICRVTTVTEIGKDVIGLRI 1218 house mouse
XP_004238316 1167 YVPIYRGQKDVTCPYCTTHFVPS--QQGQLCTVCDLAVVGADASGLLC 1212
3_pfamImport  359 CVPIYRGQKDVSCPYCTASFVPS--QEGNICGVGDIAVIGADASGLIC 404 
Q94A40       1165 YVPIYRGQKDVSCPYCTARFVPN--QEGNICTVCDLAVIGADASGLLC 1210 thale cress
Q9AUR8       1167 YVPIYRGQKDVSCPYCGSRFVPS--IEGQLCTICELAVVGADASGLLC 1212 Japanese rice
ERN04739      955 FVPIYHGQKSVLCPYCTAKFVPG--IEGQICTVCNLAVIGLDASGLVC 1000
XP_001417203 1173 FVPIYKGTKDCVCPTCGAHYVVE--EAGNVCGVCNLGKIGADATGLVC 1218
XP_003057643 1186 FAPIYRGTKDVACSCCGAKFIAEgdHVNKVCPVCNLGAVGVEAAGLVV 1233
XP_002501894 1185 FTPIYRGTADVACPTCGARFVKE--QEGTVCPVCNLGKVGADATGLVC 1230
XP_004360289 1164 MTPIYRGSPLVRCPLCSSSYQPQ--HKGKLCNICQLAEIGKDTTGLQL 1209
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