1RH7


Conserved Protein Domain Family
Resistin
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pfam06954: Resistin (This model is not part of the current CDD release)
Resistin
This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes.
Links
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Statistics
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PSSM-Id: 517486
Aligned: 28 rows
Threshold Bit Score: 78.5186
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1RH7_C         1 CSFESLVDQRIKEALSRQEPk-----TISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNGNTCHCQCSVMDWASA 75  house mouse
XP_008102433  21 QRCPVEDAIDAKISAAIDSKvs--ilVPELSCTSVSARGADVSCPSDYKATGCACGMACGSWDIRGETQCHCQCANIDWT 98 
XP_016846768  23 ACCSIDRAIDAKIKAAVDSKvsatlaKSQLTCTTIKTSGALAACLHGYTVTGCSCGKACGSWDVRDNSTCHCQCANVDWT 102
XP_007656086  22 TQWILDTDVIEKIQERVNSLvssalkDLSLVCTSVFTQGALVACPSGYKATACSCGSACGSWDIRSDTVCHCQCRGIDWT 101
NP_001230016  20 TLCSMEEAVNEKIQEGASSLvfrairSIGLECQSVTSRGDLATCPRGFAVTSCTCGSACGSWDVRAETTCHCQCAGMDWT 99 
5_pfamImport   1 TLCPMDEAVNKKLQEHTSSLisgslsKMSLDCQTVTSRGNLATCPAGFTISSCTCGSACGSWDVRAETTCHCQCAGMDWT 80 
NP_001186158  22 SLCPVDDAINEKIKDGTSSLflsgtrSLNLECRTVTSRGALATCPGGYSVTSCTCGSACGSWDVRAETTCHCQCAGMDWT 101
XP_005332174  20 SSCPMDEAVDEKIQGGISSLifaamqNIRLDCKTLTSRGNLATCPAGHAVTACTCGSACGSWDVRAETTCHCQCAGMDWT 99 
Q6QR67        20 SLCPVDEAINEKIRDVASFLipqvirNIGLECRSVTSRGDLVTCPSGFAVTGCTCGSACGSWDVRAETTCHCQCAGIDWT 99  pig
XP_004008606  20 SLCPIDKAVSKKIQDVTTSLlpeavrNIGLDCQSVTSRGSLVTCPSGFAVTSCTCGSACGSGAGRAETTCHCQCAGMDWT 99 

1RH7_C        76 RCCRMA 81  house mouse
XP_008102433  99 SARCCK 104
XP_016846768 103 AARCCK 108
XP_007656086 102 SARCCQ 107
NP_001230016 100 GARCCR 105
5_pfamImport  81 GARCCR 86 
NP_001186158 102 GARCCR 107
XP_005332174 100 GARCCR 105
Q6QR67       100 GARCCR 105 pig
XP_004008606 100 GARCCR 105
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