2RE3


Conserved Protein Domain Family
DUF1285

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pfam06938: DUF1285 
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Protein of unknown function (DUF1285)
This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. The structures revealed a conserved core with domain duplication and a superficial similarity of the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain- interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress.
Statistics
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PSSM-Id: 399724
Aligned: 82 rows
Threshold Bit Score: 143.431
Threshold Setting Gi: 123516629
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RE3_B          44 RIARDGTWFYQGTPINRPAXVRLFSSILKREED----RFYLVTPVEKVGIRVDDAPFVAVDVEVAGQ-GRKQVLTFTTHV 118 Ruegeria pome...
SDU:GNIT_3596   36 VIKSSGQWWHEGTPFTRAKLVSLFSSVLKKEGD----AYFLVTPVEKIGIQVEDVPFVIVDWRFEKE-----ALIVKTQI 106 Glaciecola ni...
Q47V82          34 QIKANGDWFYQGGIFKRLPLVKLFASVLIKEVNknvdEYFLVTPVEKVKIKVDDAPFVITQWHWTDE--NNNIMKVSTNL 111 Colwellia psy...
Q3IJG2           2 VINDQGQWFYAGSEITRPAMVKLFASVLCKEGE----QFYLKTPVEKIAITVEDAPFIIVAWRFENT-EQGQVLCCIDNL 76  Pseudoalterom...
Q5QUH6          32 HIASNGDWFYQGSQIKRSALVKLFASVLVVEDG----EYFLVTPAEKVKITVEDTPFVIVDWRQLEE-NGQQLLLLTTNI 106 Idiomarina lo...
jgi:Marme_2843  32 VIKRNGDWVHEGGKIKREKLVTLFSRVLWFDQS----EYFLVTPHEKVRIQVEDVPFLITQCDWVRPaSGRPYFRMITST 107 Marinomonas m...
WP_012069406    34 VIKANGEWFHEGGRIKRSAMVTMFSRILWYENG----EHFLVTPVEKVRIQVEDAAFLITRWQWIET-ERGRAIEFATQT 108 unclassified ...
Q6F7M7          57 TVKANGEWWHEGQLIKRQALLDLFSSVLWKEEG----KFYLKTPVEQIEIEVEDEPLLVSQVDQVDI-DGKLYLQLTTTN 131 Acinetobacter...
RUNMC:MCR_0192  52 EIRDNGEWWHEGQKMTRQSLVDLFASVLWVEWHddqaIHYLKTPTDKYQIHVADAPLFINQVTQVTD-ADGEWIKFGTTN 130 Moraxella cat...
Q4FQA5          65 VIKANGEWWHEGGHMTRESLVSLFATILWKEEKkgvtEYFLKTPVQKLRIQVEDAPLLINDVGIVNE-DINSWLEFTTTT 143 Psychrobacter...
2RE3_B         119 GDSAVAGEGNPIRXAQ-D--------------------------PA-----TGE--PAPYVHVRAGLEALIDRKSFYRLX 164 Ruegeria pome...
SDU:GNIT_3596  107 GDEVEIGPDHPIELRP-F--------------------------AAenadaEGAtpLVPYCLIRRNLWARLHQNVMYQWA 159 Glaciecola ni...
Q47V82         112 DDEFILNAEHPLIVTE-N--------------------------------------GDLYVTVRRDLQAKVHRNVYYQWA 152 Colwellia psy...
Q3IJG2          77 DRQWLISAEQPIYIQD-Y--------------------------KD-------A--AVPYIQLPYGCCARVARSVFYQWA 120 Pseudoalterom...
Q5QUH6         107 GDTLVLSSEHALTMKN----------------------------------------GVPYIVMQRGLTARVHRNVFYQWV 146 Idiomarina lo...
jgi:Marme_2843 108 NDCLQLGIDTDLELHEcD--------------------------GE----------FCPYATMRHGMRASLHRNVFYDLA 151 Marinomonas m...
WP_012069406   109 DDVLVLGVDSDLWMDWyE--------------------------EE----------ERPYVSMRYGMRALVGRNVFYGIA 152 unclassified ...
Q6F7M7         132 QDVVVVDDQHPIFMRDyA--------------------------GE----------RRPYVHVRFGINALIQRHVFYHLV 175 Acinetobacter...
RUNMC:MCR_0192 131 GDVIRLDEDHPLYFKRfG--------------------------DE----------ERVYIDTRFGLTARLMNNAMYHLI 174 Moraxella cat...
Q4FQA5         144 GDVVRLDDEHPIVLRAyDsvnnsindngdendrssdtdaahnshGEenqqsASEvqIRPYMMVRNGLTALIGRNVFYHLT 223 Psychrobacter...
2RE3_B         165 DLGEIED--------GWFGLWSSGSFF 183 Ruegeria pomeroyi DSS-3
SDU:GNIT_3596  160 EIATPTSte----kgNELLIKSKQYTF 182 Glaciecola nitratireducens FR1064
Q47V82         153 DITQEMVte----ngTELILSSADCQF 175 Colwellia psychrerythraea 34H
Q3IJG2         121 EIAQTd--------kQGYFITSAGEPF 139 Pseudoalteromonas haloplanktis TAC125
Q5QUH6         147 SHAESRTvd----gqEQWYLSSAGETF 169 Idiomarina loihiensis
jgi:Marme_2843 152 NNHAIEEied---dqTSWWVESAGKRY 175 Marinomonas mediterranea MMB-1
WP_012069406   153 ESLEQVEts----kgVGMGIISAGKSY 175 unclassified Marinomonas
Q6F7M7         176 ELGELDEteq---gkAILVLKSGDlll 199 Acinetobacter baylyi
RUNMC:MCR_0192 175 QMGRLSQiqesgqnkTVLKLSSGGKIY 201 Moraxella catarrhalis BBH18
Q4FQA5         224 EIGELTEqd----gkTTLTLQSGGNAY 246 Psychrobacter arcticus
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