4DJB


Conserved Protein Domain Family
Adeno_E4_ORF3
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pfam06931: Adeno_E4_ORF3 (This model is not part of the current CDD release)
Mastadenovirus E4 ORF3 protein
This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon.
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Statistics
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PSSM-Id: 517479
Aligned: 3 rows
Threshold Bit Score: 178.659
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DJB_A  18 CLRLKVEGALEQIFTXAGLNIRDLLRDILRRWRDENYLGXVEGAGXFIEEIHPEGFSLYVHLDVRAVSLLEAIVQHLTEA 97  Human adenovirus 5
P03241   4 CLRLKVEGALEQIFTMAGLNIRDLLRDILIRWRDENYLGMVEGAGMFIEEIHPEGFSLYVHLDVRAVCLLEAIVQHLTNA 83  Human adenovirus 2
P03241   4 CLRLKVEGALEQIFTMAGLNIRDLLRDILIRWRDENYLGMVEGAGMFIEEIHPEGFSLYVHLDVRAVCLLEAIVQHLTNA 83  Human adenovirus 2

4DJB_A  98 IISSLAVEFDHATGGERVHLIDLHFEVLDNLLE 130 Human adenovirus 5
P03241  84 IICSLAVEFDHATGGERVHLIDLHFEVLDNLLE 116 Human adenovirus 2
P03241  84 IICSLAVEFDHATGGERVHLIDLHFEVLDNLLE 116 Human adenovirus 2
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