Conserved Protein Domain Family
TPX2
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pfam06886: TPX2 (This model is not part of the current CDD release)
Targeting protein for Xklp2 (TPX2) domain
This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.
Links
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Statistics
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PSSM-Id: 517464
Aligned: 74 rows
Threshold Bit Score: 34.0911
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ERN13622     476 FSLRSDERAAKRRefflRLEERSNAKEAQKAQLQEKTKKEVDLELKRLRQSLNFKATTMPDFYGSVtEVAKKqikkIpLT 555
6_pfamImport   1 FNLHSDERAKERQifeeKLAQEREEKKRLIEEETKRKEIAEKEEIARLRRSMEHKATEVKHYTRVKvTHSEK----K-LT 75 
XP_002112111 659 FKLNTEERVEERQkfkeELKSKEEFKQMIEEQKKIELEERERKEVMALRKQMTHKANPVHHYKSVHlQGSDK----P-LT 733
XP_025171144 433 FKLHTDARLEKRKtydeQRNLRDQE-EKILKERKQIEEERNKQQIRQLRTELIHHAQPAKRYAPVKiEFANR----K-VT 506
EDO36718     135 VVLNSDKRAQERAiyemQKHEKEMEEEAILRQREEEREEEERRNIAMLRQQMVHKANPIARFKGVQiLPSEK----P-LT 209
XP_011255312 679 LELNTDKRAMKRRefdeKLKHKEVEEELKRQEQEKNRLEHEKHLKAELRKLAEVKARPMPKYKPLTtIKSTK----P-LT 753
EFN80102     673 LELNTDKRAKERRefdeKMKRKEMEEETKREEEKKRQQENEKQMRAEQRKLMEVKARPMPTYKSLIiTKAAK----P-LT 747
XP_006681154 665 IVLHTDIRAEERGayedQRRQREQEEAQVLAQQDTLRKKRDQQEIRQLRQRQTHRAQPIRHFNSVQiLPSSK----K-LT 739 Batrachochytriu...
XP_019851411 190 FTLQTELRSELRSqyefEKKLREEERQRTEEERKAIREAEEAEEIKALRRSLVHKAQPIHHYTPLSiVPSTK----K-LT 264 Amphimedon quee...
XP_002129759 812 PHLHSDERAKERRlfdeKLAFEKQQMAKLLEEQKKKQELQDKEEIARLRKSMEHKASEIKHYKTVTvALSEK----K-LT 886 vase tunicate

ERN13622     556 R 556
6_pfamImport  76 E 76 
XP_002112111 734 V 734
XP_025171144 507 K 507
EDO36718     210 E 210
XP_011255312 754 N 754
EFN80102     748 E 748
XP_006681154 740 E 740 Batrachochytrium dendrobatidis JAM81
XP_019851411 265 E 265 Amphimedon queenslandica
XP_002129759 887 E 887 vase tunicate
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