8OEV


Conserved Protein Domain Family
Elongin_A
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pfam06881: Elongin_A (This model is not part of the current CDD release)
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Links
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Statistics
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PSSM-Id: 517461
Aligned: 97 rows
Threshold Bit Score: 79.1855
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8OEV_M        595 IFEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLI--EE---TDQLWKVHC------HRDFKEE-------RPee----- 651 human
XP_006955998   20 LDNIGDVPYSLIKDILFKCHHNQLLKIEENSPELI--KY---DDEIWFQLF------KSTFIKQfqd-ltqPPs------ 81 
KDE06957       62 ITDIGDCSYDLIKNILALFPAEQLHLIETRSPHIS--EH---TGPLWKKLC------VKDFVNIriqvedg----tmkhe 126
10_pfamImport   1 LGDVGETDTHLLERILPHCSLEQLTHVENSTEGRDlsQV---TDRLWKRFY------QIEFGDKsin-qvvErmkkv-kv 69 
XP_002968045   23 FGDVGDTDLDLLRIILPHCTTDQLRHIENCSKDRDlaPV---TNELWKKCY------GRDFGPHsle-lveSklkhasks 92 
CAG1834596     25 IGDVGEVDLYLLKDILPHCNIDQLTHIEDSTQGRDlsPV---TDALWKRFY------EQQFGVEsan-tviKrmkqk-ki 93 
XP_003573427   25 VSSMDGVEMQLLKRILPHCTLDQLTRIESCTE-MDisPA---TDVLWKTFY------QRQFGEDhtn-nvvKkmkqs-gv 92 
XP_004367215   17 LKDLNRLNNDLLLRVVQKCSPNQLMSVE---NRLAstGRrldTNELWHKHV------IQTFPNSesmnifgD-------- 79 
XP_003292720  414 IKGLGRIPDKLLIVILDKCPPQQLIAIENKI------GRnvdTEELWKRHCfnlspnQSVSPEDnd-------------- 473
Q55CM9         30 CKDLGKIPDELLIPILDKCTAQQLATVESRI------GRyvdTEELWKRHChiispeKRHTLKDd--------------- 88  Dictyostelium ...

8OEV_M        652 yeSWREMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMA 693 human
XP_006955998   82 --SWRDLFLQEQTNQLNKLNKASNNLKLNQKQLELDKLNKQT 121
KDE06957      127 paSWRDLHVEETKRRDAKMEAVQARMRTQYKGYSEGRATTNV 168
10_pfamImport  70 tfKWKQLYEAKTEEMEETQQRSFERIKELYQNENAKRQSRQV 111
XP_002968045   93 qfKWRDLYEAKLKHREEKQQKGVELLQRLHMEEESKKQSRQL 134
CAG1834596     94 vfKWRQLFEAKTKEREEAQNKMGEKLKQRYAETQAKKQSRQI 135
XP_003573427   93 nyQWKDLFNAKTEKQKELEEIMIQRLAKKYQAEKAEKQSKQI 134
XP_004367215   80 --SWKQLYADLEKKNQERQLKVGMRLREKYDNSNIEKKSKQI 119
XP_003292720  474 veTWRELYVVLERNYLDKARKTGDKLRNTYNNAAKNRQSKQI 515
Q55CM9         89 -eSWRDLFTILEREYQNKTKKTGEALRKIYNNAANNKKSKQI 129 Dictyostelium discoideum AX4
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