3RQE


Conserved Protein Domain Family
PDC10_C
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pfam06840: PDC10_C (This model is not part of the current CDD release)
Programmed cell death protein 10, C-terminal
Programmed cell death 10 protein (PDCD10/CCM3) is part of the CCM complex and is required for neuronal migration. Outside of this complex, it is crucial in vascularization and in angiogenesis as it functions in vessel permeability and stability. PDCD10/CCM3 contains an N-terminal dimerization domain and a C-terminal focal adhesion targeting-homology (FAT-H) domain (represented in this entry).
Links
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Statistics
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PSSM-Id: 517444
Aligned: 18 rows
Threshold Bit Score: 127.784
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3RQE_A        76 VNFTESLLRMAAD----DVEEYMIERPEP--EFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNN 149 human
Q17958        71 VNLQESYLRMHDTs---PTNDLIVSGYEQnaDYKELTKRAIELRRVLSRVPEEMSDRHAFLETIKLIASSIKKLLEAINA 147 Caenorhabditis ...
XP_005474576  72 INYNEALLRMAGD----DMQELMIDRKEP--EFQELNERARALKHILSTLPDEINDRMGLLRTIKDVASAIKELLNTVNT 145
4_pfamImport   1 IDYHESLLRMAAD----DVEEFTIDRREP--EFQELNERARALKHILSTIPDEIYDRAGFLQSIKDIASAIKELLDMVNT 74 
XP_797062     69 INLTESLLKLAAL----DSEEYILTRRDD--KFIRMNQQARSLKAILARLPDQYANRPIFLQTIKDIACGIKDLLGALNM 142
XP_002129238  76 VSFTKSLLRMSGQ----NSQEYALQRKEK--EFFKLGEQAHTLKRILSRIPDEMNDRTRFLQTIKDIASAIKDLLSAVNE 149
XP_003390554  66 LNLHEVLLRLAGS----ECPEYVISADIV--EFQLLQKKATTLKIKLSHIPDQIQDRSEFLQTIRDIASAIKEVLDAVNE 139
XP_009027086  69 VDMCECLLRIEGSn---NSNEFLVDRVEE--PIQLLNERSTNLKKILSRIPDEIYDRKKFLETIKEIASAIRLLLDSVNS 143
XP_015786484  72 VNIIESLLRLQGTipefD--DYFIRRREE--PFQELNKKSVILRKILSRIPDEINDRPIFLATIKEIASAIKKIMDCING 147
XP_032510593  66 VNMNESLLRLQGTltdaECVDLKLNRSEE--AFQELNKKSASLKKILSRIPDEITDRKTFLETIKEIASAIKKLLDAVNE 143

3RQE_A       150 VFKKYQY-----QNRRALE 163 human
Q17958       148 VYRIVPL-----TAQPAVE 161 Caenorhabditis elegans
XP_005474576 146 VLRKYQH-----QNRRVVE 159
4_pfamImport  75 VFRKYQY-----QNKRALE 88 
XP_797062    143 IFKDESFfr-dpEQRKTLE 160
XP_002129238 150 VFKKYSTk----ANRRALD 164
XP_003390554 140 LSQNHQDlprmsEYKKTLD 158
XP_009027086 144 IFSYISEq----Y-RQVLD 157
XP_015786484 148 ISSYTYEi----SDKQVLD 162
XP_032510593 144 VSTYTPGp-----GKQALE 157
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