1EE8,3TWK,1K82


Conserved Protein Domain Family
H2TH

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pfam06831: H2TH 
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Formamidopyrimidine-DNA glycosylase H2TH domain
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain.
Statistics
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PSSM-Id: 399664
View PSSM: pfam06831
Aligned: 13 rows
Threshold Bit Score: 123.942
Threshold Setting Gi: 618797961
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EE8_A       121 LGPEPL---SEAFAFpgFFRGLKES----ARpLKALLLDQRLAAGVGNIYADEALFRARLSPFRPARSLTEEEARRLYRA 193 Thermus thermop...
P75402       135 LALDPLdqeFNHQAI--FNKGHKSN----KK-IKTFILDQTNISGIGNIYADEILFASKIHPETLAKNLNLSQYQLICQN 207 Mycoplasma pneu...
P55044       135 LGPEPL---SEAFCAdyLYARLKAQ----KRaVKLALMDNAVVVGVGNIYANESLFRAGISPHRPANRLKKKECALLVET 207 Neisseria menin...
P59065       137 LAPEPL---SEAFTVafLAARLAHC----RRsIKTALLDQSIVAGMGNIYADESLFLSGLHPTQSAHTLTPEQVQRLHGV 209 Thermosynechoco...
P9WNB9       126 LGPDPL---RSDANPssAWSRITKS----RRpIGALLMDQTVIAGVGNVYRNELLFRHRIDPQRPGRGIGEPEFDAAWND 198 Mycobacterium t...
P55045       132 IGPEPN---AKDFKLkpFEEGLAKS----HKvIKTLLLDQHLVAGLGNIYVDEVLWAAKVDPERLASQLKKSEIKRIHDE 204 Streptococcus m...
Q9CIK4       132 IGPEPT---YETFDEqiFREKLQKS----TKkIKPFLLEQTLVAGLGNIYVDEVLWLAKIHPEKVANQLTESSIHLLHDS 204 Lactococcus lac...
O34403       134 LGPEPD---AEEFTSayLKDRLAKT----NRaVKTALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAE 206 Bacillus subtil...
WP_012960008 134 LGVEPF---SEQFTSelLMNAFQKT----NRkIKVALLDQKTVVGLGNIYVDEALFRARIHPERLAHSLSKEEMAVLHKA 206 Bacillus pseudo...
3TWK_B       146 LGPDAL---LEPXTVdeFAESLAKK----KItIKPLLLDQGYISGIGNWIADEVLYQARIHPLQTASSLSKEQCEALHTS 218 thale cress
P74290       143 LGP-------EPFGAdfTAEYLYEKlkssRRpLKNALLDQRLVAGLGNIYADEVLFFCGFHPTMASNQVSLQDCELIHQQ 215 Synechocystis s...
1K82_C       128 LGPEPL---SDDFNGeyLHQKCAKK----KTaIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARV 200 Escherichia coli
P9WNC3       144 LARDPL---DPRFDCdaVVKVLRRK----HSeLKRQLLDQRVVSGIGNIYADEALWRAKVNGAHVAATLRCRRLGAVLHA 216 Mycobacterium t...
1EE8_A       194 LREVLAEAVELGGSTL 209 Thermus thermophilus HB8
P75402       208 ATDILKKAVEMKGTTI 223 Mycoplasma pneumoniae M129
P55044       208 VKAVLQRAIETGGSTL 223 Neisseria meningitidis MC58
P59065       210 ICQVLREGIAAGGTTI 225 Thermosynechococcus elongatus BP-1
P9WNB9       199 LVSLMKVGLRRGKIIV 214 Mycobacterium tuberculosis H37Rv
P55045       205 TIRILQLAIE--KGGS 218 Streptococcus mutans UA159
Q9CIK4       205 IIEILQKAIKLGGSSI 220 Lactococcus lactis subsp. lactis Il1403
O34403       207 IKNTLQEAI--DAGGS 220 Bacillus subtilis subsp. subtilis str. 168
WP_012960008 207 IVSTLEEAVEMGGSSI 222 Bacillus pseudofirmus
3TWK_B       219 IKEVIEKAVEVDADSS 234 thale cress
P74290       216 IQATLTAAIE--AGGT 229 Synechocystis sp. PCC 6803 substr. Kazusa
1K82_C       201 IKAVLLRSIE--QGGT 214 Escherichia coli
P9WNC3       217 AADVMREALA--KGGT 230 Mycobacterium tuberculosis H37Rv
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