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Predicted Permease Membrane Region This family represents five transmembrane helices that are normally found flanking (five either side) a pair of pfam02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the pfam02080) binds a ligand for export or regulation of the pore. Tetragenococcus halophilus aspT is described as a aspartate-alanine antiporter. In conjunction with aspD it forms a 'proton motive metabolic cycle catalyzed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",