1UXO,3BDV


Conserved Protein Domain Family
Ser_hydrolase

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pfam06821: Ser_hydrolase 
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Serine hydrolase
Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile. This family has an alpha-beta hydrolase fold. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family.
Statistics
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PSSM-Id: 399658
View PSSM: pfam06821
Aligned: 19 rows
Threshold Bit Score: 162.116
Threshold Setting Gi: 81718064
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UXO_A         7 VYIIHGYRASSTNHWFPWLKKRLLADgVQADILNXpnpLQPRLEDWLDTLSLYQHTLHEN-------TYLVAHSLGCPAI 79  Bacillus subtilis
Q6F9B1         4 TVIVPGVGGSEQHHWQSWLQRQLSSC-SRVEQNDW---NLPVLSDWVSHLISHVQQLEQP-------VQIVAHSFGCLTT 72  Acinetobacter b...
Q8E8L3         4 LLIVPGFGGSGPLHWQSWIAQKYTSS-LWVNDLPL---LEPKIHIWADAISRAMDNIEGK-------ILILAHSFGCLAS 72  Shewanella onei...
Q7NQ94         9 LLTVPGWGNSGDTHWHGYWEKTYPLA-RRAEQRDW---LYPTRDEWVAGLAAAVAEIPGK-------LVIAAHSLGCHTT 77  Chromobacterium...
3BDV_B        20 xVLVPGLRDSDDEHWQSHWERRFPHW-QRIRQREW---YQADLDRWVLAIRRELSVCTQP-------VILIGHSFGALAA 88  Pectobacterium ...
Q8XZQ1        23 MLTVPGLYGSGPGHWQSRWEERFPDW-RRVEQDDW---STPDLARWSARVGQAARAAQAErprhaprAVLVAHSFGCLAS 98  Ralstonia solan...
AAK89964       4 TLIVPGLNGSDEGHWQRHWLLDDPQA-RLVDQDNW---QCPVLEDWIDRLESALSAVESA--------YIVAHSLGCPLV 71  Agrobacterium f...
WP_012091839   4 TLIIPGYKGSEAGHWQRQWLHDDPSA-LLVEQDDW---HYPVLSDWMHALEAKLAENPGA--------VLVAHSLGCALV 71  Ochrobactrum an...
Q8XX01         5 VLIVPGYGNSGAMHWQSIWEAAKPGHwRRMKIEDW---DHAVCDEWVAAIDREVTALGAD-------TIIVAHSLGCLAV 74  Ralstonia solan...
Q7CYE5        20 ILIVPGYTNSGPDHWQTRWERKLSTA-RRVEQAEW---TKPVKADWVARLVEEVNAATKP-------VVLVAHSLGVPTV 88  Agrobacterium f...
1UXO_A        80 LRFLEh--LQLRAALGGIILVSGFA--------------KSLPTLQXLDEFTQGSFDHQKIIEsakhrAVIASKDDQIVP 143 Bacillus subtilis
Q6F9B1        73 LAALEq-hPQLINQVKHITLVAPANper--------fgeAGFARDSQTDYRAYFHQLKPSIKT-----QLIISENDPWLD 138 Acinetobacter b...
Q8E8L3        73 SLAI----ARHPQRVVAAILVAPASpesfs-----enghILPEHDDTPTIRNLLPKQTLGICG-----LVIASENDPWMP 138 Shewanella onei...
Q7NQ94        78 VAWLLqatLLEQRKVKGALLVAPPAipltderarasgelPEGAPLPTFAGFETLPERKLPVPA-----LLVASRDDPFCE 152 Chromobacterium...
3BDV_B        89 CHVV----QQGQEGIAGVXLVAPAEp-------------------xRFEIDDRIQASPLSVPT-----LTFASHNDPLXS 140 Pectobacterium ...
Q8XZQ1        99 LHWA----VQARDAVAGVLLVAPADp-------------------dKFGVADQLPQRALPFPA-----VLVASRNDPWLG 150 Ralstonia solan...
AAK89964      72 ANMAS---RASAAKIRGALLVAPAHl------------dRVEAMHPCIVRFGAFPQQPLAFPS-----LVVGSMNDPYMD 131 Agrobacterium f...
WP_012091839  72 AHLAS---RPSAAHVAGALLVAPADa------------eTMARKDSRFQSFAPLPRHELGFPS-----IVVASRNDEYMS 131 Ochrobactrum an...
Q8XX01        75 VHWA----VRRAVAIRGALLVAVPDp------------sASAFPSAFCDGFSPVPSARLPFRS-----IVVASNDDPYGA 133 Ralstonia solan...
Q7CYE5        89 IHAL----PEIAHKVVGAVFVAPPDv------------aNPDIRPKHLMTFGPYPRDPLPFPS-----ITIASRNDPFGT 147 Agrobacterium f...
1UXO_A       144 FSFSKDLAQQIDAALYEVQHGGHFLEDEGFTSLPIvydVLTS 185 Bacillus subtilis
Q6F9B1       139 FEEALQLAKSWQVRATNLGKVGHINVASGFGPFPE---IFDY 177 Acinetobacter baylyi
Q8E8L3       139 FNQAASLAKSFGLPTINLGLSGHINVDSGHGQWPLidvLVGN 180 Shewanella oneidensis
Q7NQ94       153 FEEARRMAELWGAEFVDGGMAGHMGSHAGLGSWPAgqrLLQR 194 Chromobacterium violaceum
3BDV_B       141 FTRAQYWAQAWDSELVDVGEAGHINAEAGFGPWEYglkRLAE 182 Pectobacterium atrosepticum SCRI1043
Q8XZQ1       151 YGQALEWGARWGAEVVDAGHAGHINADSGLGEWEPglaLLDR 192 Ralstonia solanacearum
AAK89964     132 PEELAQTATSWGSDLVNLGSVGHINIAAGFGRWPQgyaLFDR 173 Agrobacterium fabrum str. C58
WP_012091839 132 FAKAEALSHVWGSGFVDLGHSGHINVASGFSRWPEgiiLass 173 Ochrobactrum anthropi
Q8XX01       134 ISYAKSCARTWGSEFLDVGARGHLNAASRLDDWAEgykLLHH 175 Ralstonia solanacearum
Q7CYE5       148 YEHADDIASAWGSMLVDAGMSGHINAESGHGPWPEggmVFAQ 189 Agrobacterium fabrum str. C58
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