Conserved Protein Domain Family
Fez1

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pfam06818: Fez1 
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Statistics
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PSSM-Id: 399656
View PSSM: pfam06818
Aligned: 37 rows
Threshold Bit Score: 160.161
Threshold Setting Gi: 193659895
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011601607 532 TKWEVCQKSGEISLLKQQLKEIQSELSQKAGDIVVLKAQLREARSEMQASQARFQEAQAALRTRTLE------------- 598 torafugu
XP_021336943 268 TQWEVCQKSGEISLLKQQLRDSQAEVTQKLSEIFHLKTQLHETRNQMRSKDSQIDSLQTAV------------------- 328 zebrafish
XP_016153653 424 TKWEVCQKAGEISLLKQQLKDSQADVSQKLNEIVGLRSQLKEGKNFLREKEEQILTLKDSYSSKSVN------------- 490 Collared flycat...
XP_006006078 426 TKWEVCQKAGEISLLKQQLKDSQAEVSQKLNEIVGLRAQLKEAKALLRDKEEQVLNLKDSYSSKSID------------- 492 coelacanth
XP_002603684 318 TKWEMCQKSGEISLLKQQLKEAKSELSLKTNDVIASRGTIKDIKTELSEKDSQVTALQDKVSEKNAE------------- 384 Florida lancelet
7_pfamImport   1 -EWERQQKYGELSMLKSQLKDIQAESAQRGSEIVALRTRNRELQALVARRDAEAVDLNEKLNDRNLE------------- 66 
XP_001948001 295 TEWGLCQKSGELAHVKSQLKDTQNELTTKGHEVIALKSEIRDLLQKLESKERRIDEIEGRRPERLDSdnggdgnccddql 374 pea aphid
EEZ98911     308 TEWGLCQKTGEISLLKSQLKDYQNEQTAKCQELLQLRTEHRDFREQLDLREAEISELRHQSEEKDAE------------- 374 red flour beetle
OWR54544     125 TEWSLCQRAGEIALLKTQLKEAQNEQTAKGHEYLTLKSDCRQLREALDKKDKEILRLRAESEEKEKS------------- 191 Danaus plexippu...
XP_004911381 385 TKWEVCQKAGEISLLKQQLKDCQADLSQKLNEIVGLRTQLKEAKAFLREKEEQIASIKDSYSSKSVS------------- 451 tropical clawed...
XP_011601607 599 ------------LEVCENELQR------------------------R------------KSEAELLREKLGRVEEELTRL 630 torafugu
XP_021336943 329 ------------------QGAR------------------------R------------KCTMPAFED-----------T 343 zebrafish
XP_016153653 491 ------------LEICEGELQR------------------------K------------MSEVQVLREKLNHCELEVSGL 522 Collared flycat...
XP_006006078 493 ------------LEVCENELQR------------------------K------------MNEVQLLREKLNQYELEISGL 524 coelacanth
XP_002603684 385 ------------ILHYQDEVAK------------------------Q------------QCELDNLSDTLRKREDELMDL 416 Florida lancelet
7_pfamImport  67 ------------IGELEQRLSE------------------------AsspagtwhrspgSISPQSLRNPSGTFSEPNSGN 110
XP_001948001 375 aadklcslvgrlNEQVENELSK------------------------Snklls--ecystEDLHSLLPKKDTEADSPLERF 428 pea aphid
EEZ98911     375 ------------IKLLKEQLAR------------------------L------------GNKSPTIDD----LKEEIREL 402 red flour beetle
OWR54544     192 ------------MKKLQAEVER------------------------LnndlmnsvtdltKTKESNKKE-IEKLKTEVKEL 234 Danaus plexippu...
XP_004911381 452 ------------LEICENEMQRkqseaqqmkeklsqceqeisslkeA-----------------------------LASL 490 tropical clawed...
XP_011601607 631 ----RDALSNHGVLSVSGSgtlkgqcmglsiqqgravggrggpspcvyrdgeehhlvwgGESDEAKAQRQNa--ETVLAL 704 torafugu
XP_021336943 344 ----RSDMDT----------------------------------------------------------------GETGGS 355 zebrafish
XP_016153653 523 ----KRTLASMAPPAGPFGgelgek----------------------------lrdplaCESDEAKMQRQSe--DSVNSL 568 Collared flycat...
XP_006006078 525 ----KQGLAN----PGHTHtydgeld--------------------------klgnpltCESDEAKMKRQSe--DAVHGL 568 coelacanth
XP_002603684 417 ----KDSYRQVK--EDLSNvraeldnk-------------------------ikeeqliSQCDEVKERRKNkerDLIESL 465 Florida lancelet
7_pfamImport 111 whddRNYLSSSSPP------------------------------------------------------------GALTSL 130
XP_001948001 429 ----RE-------------------------------------------------------------------------L 431 pea aphid
EEZ98911     403 ----REELSDMSLSEYGSV----------------------------------------EPGRS----------QRISQE 428 red flour beetle
OWR54544     235 ----RQELSDVSLSGYEGIecgrtmrgi-----------------------ydvcktneYHWTS----------SDSALE 277 Danaus plexippu...
XP_004911381 491 ----GQ--------NPYTIelnekl-----------------------------rdtlaCESDEAKMKRQNe--DSVISL 527 tropical clawed...
XP_011601607 705 RQQVDRLKA-----------------ELLYERRTSEEHLSHFEEERRVWQEEKEKVIRYQKQLQQNYIQMYRRNRDLERV 767 torafugu
XP_021336943 356 SATEERLRA-----------------ELLLERRQNEAQTSAFESERKTWQNEKEKVIRYQKELQASYLEMYHQNEALERE 418 zebrafish
XP_016153653 569 RRELERLQT-----------------ELKLERQQREQQVMDFEEERRTWQEEKEKVIKYQKQLQLNYVEMYQKNQLLEHK 631 Collared flycat...
XP_006006078 569 KKQLERLQS-----------------ELRLERQQREQQVVGFEEERRTWQEEKDKVIKYQKQLQLNYVEMYQKNQLLEQQ 631 coelacanth
XP_002603684 466 KVEVQRLRN-----------------ELKTVHQRHDAQLMEFERERAIWQEEKEKVIHYQKQLQLNYVQMFRKTKNLEKE 528 Florida lancelet
7_pfamImport 131 KR--DELIK-----------------RLYEAEARCNEQEKFFNIERRQWADDKSRVIRYQKQLQANYVQTYKRCGALERE 191
XP_001948001 432 ERHTAKLIR-----------------VLNEERKN-------WDQERLKWFQEKEKVLCYQRQLQMNYVQMFRRTQAFEAQ 487 pea aphid
EEZ98911     429 DLEIECSCS-----------------SLAKLKQEIASKTKDFENERVVWAQEKEKVLRYQRQLQMNYVQMYRRTRALEAE 491 red flour beetle
OWR54544     278 DAEVQRLNGelpdscsepcpagaivdRLKCEIQNKEQQ---FNNERRKWSDEKDKVLRYQKQLQMNYVQMFKRSRTLEAE 354 Danaus plexippu...
XP_004911381 528 KKDIERLQL-----------------ELTVEKQQRDQQVVDFEEERHTWQEEKEKVIKYQKQLQLNYVEMYQKNQQLEQR 590 tropical clawed...
XP_011601607 768 MR 769 torafugu
XP_021336943 419 La 420 zebrafish
XP_016153653 632 VN 633 Collared flycatcher
XP_006006078 632 IN 633 coelacanth
XP_002603684 529 VQ 530 Florida lancelet
7_pfamImport 192 VK 193
XP_001948001 488 Ie 489 pea aphid
EEZ98911     492 Ve 493 red flour beetle
OWR54544     355 Id 356 Danaus plexippus plexippus
XP_004911381 591 MA 592 tropical clawed frog
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