Conserved Protein Domain Family
Fez1

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pfam06818: Fez1 (This model is not part of the current CDD release)
Fez1
This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth. Note that some family members contain more than one copy of this region.
Statistics
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PSSM-Id: 517433
Aligned: 31 rows
Threshold Bit Score: 147.866
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_029691038  507 TKWEVCQKSGEISLLKQQLKEIQSELSQKAGDIVVLKAQLREARSEMQASQARFQEAQAALRTRTLE------------- 573
10_pfamImport   1 TKWEVCQKAGEISLLKQQLRESQAEVAQRAGEMVALRAQLRELSGQLREREEAVLGLKDSYSSKSLA------------- 67 
4_pfamImport    1 TKWEVCQKAGEISLLKQQLRESQAEVTQRAGEMVALRGQLKELNAQLREREETMLGLKDSYSTKSVE------------- 67 
9_pfamImport    1 TKWEVCQKAGEISLLKQQLRESQAEVTQRAGEMLALRGQLKELNAQLREREEAMLGLKDSYSSKTLE------------- 67 
XP_009301973  440 TKWELCQKAGEISLLKQQLRESQNEVTQRAGETVALRGQMKDLNAQLKEREDTMIGLKDSYNSKSRE------------- 506
XP_007254138  452 TKWEVCQKVGEISLLKQQLRDSQNEVTQRAGEMVALRGQLKELNAQLKEREEAMLGLKDSYNRKSRE------------- 518
XP_032760106  468 TKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQAS------------- 534
6_pfamImport    1 SEWERQQKYGELSMLKSQLKDIQAESAQRGSEIVALRTRNRELQALVARRDAEAVDLNEKLNDRNLE------------- 67 
3_pfamImport    1 TEWGLCQKSGELAHVKSQLKDTQNELTTKGHEVIALKSEIRDLLQKLESKERRIDEIEGRRPERLDSdnggdgnccddql 80 
EEZ98911      308 TEWGLCQKTGEISLLKSQLKDYQNEQTAKCQELLQLRTEHRDFREQLDLREAEISELRHQSEEKDAE------------- 374
XP_029691038  574 ------------LEVCENELQRR------------KSEAELLREKLGRVEEELTRL----RDALSNHGVlSVSgsgtlkg 625
10_pfamImport  68 ------------LERCEGELQRT------------LAEVSLLRDKLGVFEAEVLGL----KQALVELGGaGRAavpspqs 119
4_pfamImport   68 ------------LEKCEGELRRT------------L-------------------L----KRALNEVSRgAEEaqlchea 100
9_pfamImport   68 ------------LEKCEGELRRT------------LSEVSILREKLGVFEAEVLSL----KRALSE----APTsdtl--- 112
XP_009301973  507 ------------LERCEGELKRT------------LAEVSMLRDKLVVFESEVVGL----KRALNELSCrSDHtavlssi 558
XP_007254138  519 ------------LERCEGELKKT------------LAEVSILRDKLVVFEAEVLGL----KRALGELSYtSDHsvgslgs 570
XP_032760106  535 ------------LELSEGELPPA------------CLKPALTPVDLVEPQEALASC----ESDEAKMRRqAGVaa----- 581
6_pfamImport   68 ------------IGELEQRLSEAsspagtwhrspgSISPQSLRNPSGTFSEPNSGNwhddRNYLSSSSPp---------- 125
3_pfamImport   81 aadklcslvgrlNEQVENELSKSnklls--ecystEDLHSLLPKKDTEADSPLERF----RE------------------ 136
EEZ98911      375 ------------IKLLKEQLARL------------GNKSPTIDD----LKEEIREL----REELSDMSLsEYGsv----- 417
XP_029691038  626 qcmglsiqqgravgg--rggpspcvyrdgeehhlvwggESDEAKAQ-RQnA----------E-TVLALRQQVDRLKAELL 691
10_pfamImport 120 ppdgp----------------------pppqadallslQSDEAKAQ-RQa-------------eAGGLRRQLERLQGELR 163
4_pfamImport  101 qm---------------------------rqeaqlrheAQLCQEVQlRQdGhqpqrgqeghWdEAGELRRQLEQLQAALR 153
9_pfamImport  113 -----------------------------------lslQSDEAKAQ-RQeA----------Qr-TGELRRQLEQLQAALR 145
XP_009301973  559 sgssslpwaglhs-----prtpeplsvlgstvetflslQSDEAKAQ-RQe--------------AGELRRQLERLQGELH 618
XP_007254138  571 slsgssslpwgglhsprtpegltplsplspvvdtllslQSDEAKAQ-RQe--------------AGELRQQLERMQSELR 635
XP_032760106  582 -------------------------------------aASLVSVDG-EVdAg--------gEgGTRALRREVGRLQAELA 615
6_pfamImport  126 --------------------------------------------------------------gALTSLKR--DELIKRLY 141
3_pfamImport  137 -------------------------------------------------------------------LERHTAKLIRVLN 149
EEZ98911      418 -------------------------------------ePGRSq--------------------RISQEDLEIECSCSSLA 440
XP_029691038  692 YERRTSEEHLSHFEEERRVWQEEKEKVIRYQKQLQQNYIQMYRRNRDLERVMR 744
10_pfamImport 164 LERQQRERQALSFAKERHTWQGEKERVLKYQAQLQLNYVEMYQKNQALEQQVG 216
4_pfamImport  154 LERQQRERQALNFDHERHTWQDEKERVLKYQAQLQLSYVETLQKNQALEKRMT 206
9_pfamImport  146 LERQHRERQALNFDQERHTWQDEKERVLKYQAQLQLSYVETLQKNQALEKRMS 198
XP_009301973  619 LEKQQRERQALTFAQERHTWQDEKERVLKYQAQLQLSYVETLQRNQALEERVG 671
XP_007254138  636 LERQQRERQAFTFAQERHTWQDEKDRVLKYQAQLQLSYVETLQRNQALEERVG 688
XP_032760106  616 AERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLR 668
6_pfamImport  142 EAEARCNEQEKFFNIERRQWADDKSRVIRYQKQLQANYVQTYKRCGALEREVK 194
3_pfamImport  150 EERKN-------WDQERLKWFQEKEKVLCYQRQLQMNYVQMFRRTQAFEAQIE 195
EEZ98911      441 KLKQEIASKTKDFENERVVWAQEKEKVLRYQRQLQMNYVQMYRRTRALEAEVE 493
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