Conserved Protein Domain Family
DctM
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pfam06808: DctM 
Tripartite ATP-independent periplasmic transporter, DctM component
This entry represents the transmembrane segments from a diverse range of transporter proteins from the tripartite ATP-independent periplasmic (TRAP) transport system, in which the driving force for solute accumulation is an electrochemical ion gradient and not ATP hydrolyzis. The first TRAP transporter to be characterised was the high-affinity C4-dicarboxylate transport (Dct) system from Rhodobacter capsulatus which consists of ESR (DctP) and small (DctQ) and large (DctM) integral membrane proteins. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. This entry also includes SiaM (involved in sialic acid uptake) and YiaN (involved in the uptake of 2,3-diketo-L-gulonate).
Links
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Statistics
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PSSM-Id: 284275
Aligned: 17 rows
Threshold Bit Score: 236.768
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O29619 128 LAVIFVLEATRRVVNPALVVVAIiFILYAKFGASlpgvl-shpsyDWKqILEHLYYTkegifgtP----IAVSSSFVVL- 201 Archaeoglobus fulgidus
Q8ZKS0  12 IAVFVVLLAMGAPIGICIVIASFsTMMLVLPFDI-----------SMF-ATAQKMFS-------S----LDSFALLAVPf 68  Salmonella enterica s...
Q9Y8U1  75 LVMFAALLKYRAI----FILNVL--LFIYTLNGSwapypfdhpgiRLErIITAMSVEfe----tGvfekLPQLALTLIGa 144 Aeropyrum pernix
Q2YRV7 148 LLILILLEATRRSVGWPLPIISVlFMLYALYGPSmpgil-vhpgaTVSqLVDHLYLTtqgiygiA----LGVVATYVFH- 221 Brucella abortus 2308
Q8FRN3 157 FYWVAVLEILRRCAGPIVAGLALaVSIYPMFADIipvgflqgisyDPVtLAQVHVMGtesihglP----LQTAATILVG- 231 Corynebacterium effic...
Q89NA6 151 VMWVMLMEALRRTGGWSLLLSVFpFTVYPLFAESgwlgpfrgtqsTLEqATAYHVLSgesllgiP----IQAFADTVIG- 225 Bradyrhizobium japonicum
Q92WB7   5 VGSFLVLMLVGVPVAISMAAASV--LYLVSYNVA-----------PDI-IAAQRMIA-------G----VESFPLLAVPf 59  Sinorhizobium meliloti
Q9CKH6   7 LGTMFLLTVFGLPLFYSIIFASI-VTLFYFLPNI-----------PVT-IVAQQVMQ-------G----LDTNALQALAf 62  Pasteurella multocida
Q8ZL80   7 LCCLLGGIAIGLPIAWSLLLCGA--ALMAYLDMF-----------DVQ-IMAQTLVN-------G----ADSFSLLAIPf 61  Salmonella enterica s...
Q9K7H0   6 LVIMFVLLALGFPMMIPMLAASAiVLFLFFSHVD-----------PM--ILIQQMME-------G----ISSFVLLAVPl 61  Bacillus halodurans

O29619 202 FVIFGAFLERSGAGRFFIDLAYSLTGWMVGGPAKAAVVSSALMGTISGSSVANTVTTGAFTIPLMKRVGYKPEFAGAVEP 281 Archaeoglobus fulgidus
Q8ZKS0  69 FVLSGVIMNSGGIAARLVNFAKLFTGKLPGSLSYTNIVGNMMFGAISGSAIAASTSIGGVMVPMSAREGYDRGFAAAVNI 148 Salmonella enterica s...
Q9Y8U1 145 FMLFISIAQAFGAVDSVIRLVIGALGSRPRLLPQAAVVGSMVIAMVSGSGAANAASTGSITIPLMKKAGMPPVKAAAIET 224 Aeropyrum pernix
Q2YRV7 222 FVLFGVFATRIGLGQLFLDCAAWVAGRFAGGPAKVSIFGSALFGMISGSSVANAVTVGSLTIPAMIRLGYKRHFAAAVES 301 Brucella abortus 2308
Q8FRN3 232 FMLFGVTLQHTGGAEFFNDLSRAIFGRYRGGSAKVSVASSASMGMMSGSAVSNVLTTGPMTIPAMIRSGFTPKTAGAIEA 311 Corynebacterium effic...
Q89NA6 226 FLVFGTALMMTGAGKFFINLAFALCGTFRGGAAKVCIFASGLLGMMSGSIISNVLTAGTMTIPVMKKSGFRASYAGAIEA 305 Bradyrhizobium japonicum
Q92WB7  60 FILAGNLMNSAGVTGRIYSFAVALVGWMKGGLAQVNIVGSVIFSGMSGTALADAAGIGTIEIKAMKDHGYPVDAAVGVTA 139 Sinorhizobium meliloti
Q9CKH6  63 FFLAGELMSVGGITNRIIRFVTSIIGRWKGSLAYINIFSSLFFGSISGSAVASTAAIGSSLIPEMKKRGYPAPFSAALTQ 142 Pasteurella multocida
Q8ZL80  62 FVLAGEIMNAGGLSKRIVDLPMKLVGHKPGGLGYVGVIAAMIMASLSGSAVADTAAVAALLVPMMRSANYPINRSVGLIA 141 Salmonella enterica s...
Q9K7H0  62 FIFAADIMSKGKTSKRLLDFVGAFVGHIRGGYAVTTAITCALFGSISGSTQATVVAIGKPMRERLLSLGYKDSKAIALII 141 Bacillus halodurans

O29619 282 AASTGGQIMPPIMGAAAFIMAeFVGMPYINIVYAAIIPAFLYFFGVFSAVDFEARKENLRG-LSREELPSPLQVLKGGW- 359 Archaeoglobus fulgidus
Q8ZKS0 149 ASAPTGMLIPPTTAFILYALA-SGGTSIAALFAGGLVAGVLWGVGCMLVTLVVAKRRNYRV-FFTVQKGMALKVAVEAIp 226 Salmonella enterica s...
Q9Y8U1 225 ASSIGGQLMPPIMGISAFVMAdYLGVSYFDVVARGWAPALIYYIGLAAAVYLASK--AFLS-GTAALNIGYGRLEVYKAt 301 Aeropyrum pernix
Q2YRV7 302 ASSTGGQITPPIMGAAAFLMIeFLNLPYTTIILAAIVPAFMHFFGVLMQVHFEAKRTGLRG-MTKEEMPDLKEALKRDW- 379 Brucella abortus 2308
Q8FRN3 312 TASSGGSITPPIMGTAAFLMVsFLGIPYTEIIIAATIPAALYFIGIFLQVDGYAALRNLHG-EDRKLLPRVSQALRDGW- 389 Corynebacterium effic...
Q89NA6 306 CASTGAVLAPPVMGATAFVIAqFLNVSYADVAVAAIIPAALYYVGLFMQVDAYAARHGLKG-IPRAELPRIMDTIKDGW- 383 Bradyrhizobium japonicum
Q92WB7 140 ASATLGPIFPPSLPFVIYGM--MANVSIGALFMAGVVPGVVMTVLMMLTVAIFAYKRGWGS-DTPFEMKRLLAASLEVVv 216 Sinorhizobium meliloti
Q9CKH6 143 SASIIGPIIPPSVPMIVFAALaGAGVSVGKMFMSGIIPGLMIALTLILITFIISKIKGYGNhSVEFSLKEVKESAKDAVw 222 Pasteurella multocida
Q8ZL80 142 SGGIIAPIIPPSIPFIIFGV--SSGLSISKLFMAGIAPGIMMGAALMLTWWWQAGRLNLPS-QPKATPREIWQSLVSGIw 218 Salmonella enterica s...
Q9K7H0 142 NASDVALLIPPSIGMIIYGLA-APNVSVGDLFIAGIGPGLLVMFMFAAYSYYHAKKNNIPL-AERFSWAARGRATAKALl 219 Bacillus halodurans

O29619 360 ------------------------------------------YYLVPLFIIIYMLVSGYTPILAGVYSIYAV--IAIMIL 395 Archaeoglobus fulgidus
Q8ZKS0 227 ------------------------------------------SLLLIVIIVGGIVQGIFTAIEASAIAVVYT--LLLTMV 262 Salmonella enterica s...
Q9Y8U1 302 ------------------------------------------SLMASILLLI-ILMGARREY--PAYAALQSsiLLLALL 336 Aeropyrum pernix
Q2YRV7 380 ------------------------------------------PTIIPLVVLIAVLLSGYTPYLAAFWGITLC--IAVGLL 415 Brucella abortus 2308
Q8FRN3 390 ------------------------------------------PYVIALGILTGMLLTMPSEAQVPFYIVALL--LGIALV 425 Corynebacterium effic...
Q89NA6 384 ------------------------------------------YYVFVIALLIVMLLYFKRESHAPFYATALL--LVLNQL 419 Bradyrhizobium japonicum
Q92WB7 217 vlavplfiyllmaaglsmnlavgialvvllaldwyfdfsavmALMTPIILIGGMTMGWFTPTEAAVAAVIWS--LFLGLV 294 Sinorhizobium meliloti
Q9CKH6 223 ------------------------------------------ALLCPIIILYGIISGIFTATEAGAVSVVYA--YLIGTF 258 Pasteurella multocida
Q8ZL80 219 ------------------------------------------ALFLPVIIIGGFRSGLFTPTEAGAVAAFYA--LFVAVV 254 Salmonella enterica s...
Q9K7H0 220 ------------------------------------------PLGFPIIIIGGIYAGIFSPTEAAGISVLYA--LILEVI 255 Bacillus halodurans

O29619 396 KplimnyrkpaEQREPLGKVLKGsilnilsaLEHGGRSA----TTVAMACASAGIIVGVVTLTGLGFKIAAAAIALS--- 468 Archaeoglobus fulgidus
Q8ZKS0 263 F----------YRTLKIKDLPSI--------LLQTVVMT----GVIMFLLATSSAMSFSMSITNIPAALSDMILGISa-- 318 Salmonella enterica s...
Q9Y8U1 337 aaa------eaSRGKSLHEVAGRil----arLAETLKIFsgfvADITILLAALGVMTGLMTITGIPTRVGFLLLEVGa-- 404 Aeropyrum pernix
Q2YRV7 416 Np---------RKRMTIGEVFEG--------LRDGAKYA----LAVGAAAATVGIIVGVVTLTGVGFKISYIVTSTAaql 474 Brucella abortus 2308
Q8FRN3 426 Rp---------SVKFGFKELFEM--------MLDAGKSL----GQIIAIIAGVGLILGGLSSTGVALSLSRDLLMLVg-- 482 Corynebacterium effic...
Q89NA6 420 Fs--------kDTRWTLATIGKF--------LEVNGRTF----VELVGILAGCGLLIGAFSMTGVVSSLANDLLHIAg-- 477 Bradyrhizobium japonicum
Q92WB7 295 R----------YRTMTMSTLARA--------TFDTIETT----ASVLFIVTAASIFAWLLTVSQAAQMLSGAILTITd-- 350 Sinorhizobium meliloti
Q9CKH6 259 V----------YKELNLERLKKA--------FISSLKGT----ITVMLIVGASSIFAWMIARLQISHQVASWVSSVCs-- 314 Pasteurella multocida
Q8ZL80 255 I----------YRELTFSSLYHV--------LVNAAKTT----SVVMFLVAAAQVSAWLITIAELPMMVSDLLQPLVd-- 310 Salmonella enterica s...
Q9K7H0 256 I----------YRSIKLKEIPSI--------ALSTGLVT----AAVFILVAAGQAFSWLISFADIPRTFTDVVFSNDp-- 311 Bacillus halodurans

O29619 469 ------------------HGylPIILALTMLVSL--ILGMGVPTTANYIITSTIAAPAIITFMAQGygmpvrefletype 528 Archaeoglobus fulgidus
Q8ZKS0 319 ------------------NK--LVILLVITVFLL--IIGAFMDIGPAILIFTPILLPIMAKLGVDP-------------- 362 Salmonella enterica s...
Q9Y8U1 405 ------------------GN--K-ILLVMLAFVFgyLVGLGLPPVVTYILTVVVIGPYMLQAGFNP-------------- 449 Aeropyrum pernix
Q2YRV7 475 atyfgtilpvswfapqtlTL--LFTLVMTGMVCI--LMGCGIPTTANYIIMATIAAPALGLLGVEP-------------- 536 Brucella abortus 2308
Q8FRN3 483 ------------------GNliL-LLIAAALACF--ILGMGLTISAAYVFLAIVMVPAIIAMDVNP-------------- 527 Corynebacterium effic...
Q89NA6 478 ------------------DNpfL-LLGMCALTSL--ILGLGLTTTACYIFLAILVAPALEKLGLNR-------------- 522 Bradyrhizobium japonicum
Q92WB7 351 ------------------NK--WVFLILVNLLML--FVGCFLDTIAAITILVPILLPLTAQFGIDP-------------- 394 Sinorhizobium meliloti
Q9CKH6 315 ------------------SP--LEALILINVIVL--FIGMIMDPTAALTILVPVFMPIVNQFGISP-------------- 358 Pasteurella multocida
Q8ZL80 311 ------------------SP--RLLFIVIMISIM--VVGMVMDLTPTVLILTPVLLPLVKEANIDP-------------- 354 Salmonella enterica s...
Q9K7H0 312 ------------------SA--LYVLLIVALFFF--IGCMFVDPIVVILILTPIFYPVAMQAGVDP-------------- 355 Bacillus halodurans

O29619 529 lvLPAHMFVFYFGVAADLTPPVALAAYAGSAIAggdpwktgiNAVKIGIGKYLVPYLFIFSPALLLIGVKTPA 601 Archaeoglobus fulgidus
Q8ZKS0 363 --VHFGIIMIYNLAIGTITPPVGSGLYVGASVG---------KVKVEEVIKPLLPFYGAIIGVLLLITYIPEI 424 Salmonella enterica subsp. e...
Q9Y8U1 450 --WAVHFYAFLLGVMSELSPPTSVTAAVTSRIA---------GAGFVETMIESIKFAMPLFTVMAGVLLEPGL 511 Aeropyrum pernix
Q2YRV7 537 --IVAHFFVFYYGVLADITPPVALAAYAAAGMAgadpfktgnTAFRLGLGKVLVPFVFVFSPSLLLVTSNFNW 607 Brucella abortus 2308
Q8FRN3 528 --IAAHLFIIYWASISYITPPVGLAAFAAAGISkaspmatsfEAMRFGAVKYVVPFGFVLNPALVAQDSLPNI 598 Corynebacterium efficiens
Q89NA6 523 --MAVHMFIFYWGMLSSITPPVAIASFAAAGIAgspamktgwESMWVGSIIYFIPFFFVLNPALVLQGSSPYL 593 Bradyrhizobium japonicum
Q92WB7 395 --VHFGLIMTLNLMIGLLHPPLGMVLFVLSRVA---------KLSVERTTMAILPWLVPLFIALILITFVPAV 456 Sinorhizobium meliloti
Q9CKH6 359 --IHFGLVVILNLMIGLITPPVGYLIFLSANIA---------ECEPIKVLKESLPFLLSLLGLLILLILVPEF 420 Pasteurella multocida
Q8ZL80 355 --IYFGVMFIINCSIGLITPPVGNVLNVISGVA---------KLKFDDAVRGVFPYVVVLMSLLVLFIFIPEL 416 Salmonella enterica subsp. e...
Q9K7H0 356 --IHLGVVIVFQAALGSATPPFGVDIFTASAVF---------NKSYLDVIRGTPPYIVMLIIASILIIVFEEI 417 Bacillus halodurans
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