2VSF,8REV,7K01


Conserved Protein Domain Family
HBB
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pfam06777: HBB (This model is not part of the current CDD release)
Helical and beta-bridge domain
HBB is the domain on DEAD-box eukaryotic DNA repair helicases (EC:3.6.1.-) that appears to be a unique fold. It's conformation is of alpha-helices 12-16 plus a short beta-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. XPD is an assembly of several domains to form a doughnut-shaped molecule that is able to separate two DNA strands and scan the DNA for damage. HBB helps to form the overall DNA-clamping architecture. This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).
Links
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Statistics
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PSSM-Id: 517418
Aligned: 40 rows
Threshold Bit Score: 119.788
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2VSF_A             218 ADREAQAYGDPELSQKIHVsdLIEMIRSALQSMVSERcGKGDv---RIRFQEFMEYMRIMNKRSEREIRSLLNYLYLFGE 294 Thermopla...
mbrcrk:TON_1040    263 AIKEADEYREHEIANFLSI--FGKGLEMLYEEKLRER-DVHEv---PIQPELVFAHVVDILNLDGRYLVKTLNEMVAVGD 336
WP_013467410       238 AVKEAEEYNEHEIANFLSI--FLKGLENLYNERLKDR-EVEEi---PILPESIFSHVFDILNISERLLVRILREIVEVGD 311 Thermococ...
1_pfamImport         1 AIKEADEYKEHEIANFLSI--FLKGLENLYQEKLRDL-KIDEv---PIIPESIFYHVFDVLKINEKQLIRILDQMVKAGD 74 
WP_013905033       238 AVKEAQEYGEGDIESFLLI--LLRGLELLYEERLKNY-EAYEv---PIRPEDIFRHVIEVTGYLGRAIVRMLNDMVEVGD 311 Pyrococcu...
Q8U2A6             240 AIKEAEEYGEKDIENFLSI--LLRGLEILYKEKLENY-ESEEv---PIRPEEVFLHVASVLGWSGREIGMMLEDMIEVGD 313 Pyrococcu...
WP_013748813       238 AIKEAEEYGEKDIANFLSI--FLRGLEILYREKLENY-EIQEv---PLSPMEIFSHVASILGFETRDILMVLNDMVEIGD 311 Pyrococcu...
Q9UZ12             238 AIKEANEYGEKDIENFLSI--FLRGLEIIYKEKLENY-EISEv---PLSPASIFEHVSSILGLRERDLLRFLQEMVEVGD 311 Pyrococcu...
CIDAM:MMALV_08560  243 ALDEAGLFKKPEVCDGVTIdaFIRSVRAAMRDIGSKY-LGFNekekVIPADSLENSVCTALNIDRMQLTAAINRTIELGE 321
licsiro:TALC_00787 264 ALDECMAFNKPPVSSTMTLddFVRAVRRVVKGLASKK-IPLGekeaMLEPREFETALASESGTDVTGLRSIVEKLTELGE 342

2VSF_A             295 YVeNEKEKVGKVPFSYCSSVAsriiafsdqdeek-yaailspedggymQAACLDpSGILEVLKES-KTIHMSGTLDPFDF 372 Thermopla...
mbrcrk:TON_1040    337 SIrEDKIEKGKPPRSYIGRVGefllfwlsligredylflmsrdkglslELVALDpSKALSFVKNVqSAIFMSGTLTPLEA 416
WP_013467410       312 AIrEDKIEKNKPPRSYVGRVGefllnwlsvigredylfimskdrgfslELVALDpSKALDFINDIqSAIFMSGTLTPLEA 391 Thermococ...
1_pfamImport        75 AIrEDKIERSLPPRSYVGRVGeflllwfaligkedylflmsrekgfslELVALDpSKALSFVKNVqSAIFMSGTMTPLEA 154
WP_013905033       312 AIrEDRIERNLPPRSYIGRVGeflltwlslansedylhlmsrekglslEIVALDpSRALDFVEEVhSAIFMSGTLSPLEA 391 Pyrococcu...
Q8U2A6             314 AIrEDRIERNLPPRSYVGRVGeflwnwlalreredylhlftkerglalELVALDpSVALEFLEEVhSAIFMSGTLSPLEA 393 Pyrococcu...
WP_013748813       312 AIrEDRIERNLPPRSYIGRTGefllnwlslmdrsdyihlfskergpalELVALDpSIALDFLNDVhSAIFMSGTLTPLEA 391 Pyrococcu...
Q9UZ12             312 AIrEDKIERNLPPRSYVGRVGeflwnwisladrsdylhvftrekglalEIVALDpSVALEFLEDVhSAILMSGTLSPLEA 391 Pyrococcu...
CIDAM:MMALV_08560  322 KR-EEAIADTDAPSSPVLEFGrlmeawvkspadryvravrsnedgeylTASCIDpTDIVRFMNALpGAVHMSGTLQPLAQ 400
licsiro:TALC_00787 343 KR-QEAIADTDSPDSPLLDFAillgkwvkspedryikvvrtneegefiQASCIDpADVPAFLRKLpGAVHMSGTLQPLAQ 421

2VSF_A             373 YSDItgfeipfkk--igeifppeNRYIAYYDGVSSKYDT 409 Thermoplasma acidophilum
mbrcrk:TON_1040    417 FRDVmgienaklk-kfprmvkreNAQVLVAKDVSTRGEE 454
WP_013467410       392 FKDImgienaklk-kfprmvkkeNALVLVAKDVSTRGEE 429 Thermococcus barophilus
1_pfamImport       155 FADImgiegklkk--fprivkkeNAIVLVAKDVSTRGDE 191
WP_013905033       392 FRDIigveaelkk--fprivkreNALVLVARDVSTRGEE 428 Pyrococcus yayanosii
Q8U2A6             394 FRDIigvkaelkk--fprmikreNAIVLVARDVSTRGIE 430 Pyrococcus furiosus
WP_013748813       392 FRDIigvqaklkk--fprivkseNAIVLVARDVSTRGEE 428 Pyrococcus sp. NA2
Q9UZ12             392 FRDIigvnarlkk--fprmvkseNAIVLVARDVSTRGEE 428 Pyrococcus abyssi
CIDAM:MMALV_08560  401 YARVmglpsnsvprtypspfpaeNKLVVYAKDVTTNYND 439
licsiro:TALC_00787 422 YARVmglpdntlprkypspfpkeNKKVVYATDVTSEFKT 460
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