6DS5,6MLU


Conserved Protein Domain Family
Seipin

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pfam06775: Seipin 
Putative adipose-regulatory protein (Seipin)
Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene. This gene is implicated in the regulation of body fat distribution and insulin resistance and particularly in the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity with other known proteins or consensus motifs that might predict its function, but it is predicted to contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia syndrome and distal hereditary motor neuropathy type V.
Statistics
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PSSM-Id: 399628
View PSSM: pfam06775
Aligned: 123 rows
Threshold Bit Score: 67.9293
Threshold Setting Gi: 209556858
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DS5_A            50 LLLLWVSVFLYGSFYYSYMP-TVS-HLSPVHFYY--RTDCDsstts-------------lcsfPVANVSLtkg------- 105
EGG21824         114 LLCAFISLINYAVLYSYFVP-KVS-SEEPLYFDF--NGHRS----------------------VVATTEV---------- 157 Cavenderia ...
EFA81096          72 GLVGTLSLANYFIIYSYYVP-RVV-TEEPLYFEF--GKKIT------------------------AHTDI---------- 113 Heterosteli...
Q54K07            72 SFLFFVTILSYYAIYATLVP-KVS-TEEPLFFDYsyKSTKK----------------------IVADVQA---------- 117 Dictyosteli...
jgi:MICPUN_63945  51 ILLLFLSLALVVVFRILVVPtTPAsTRQELVFDY--VPAA-----------------------PTAVSSFlgaketkala 105 Micromonas ...
EEH53274          48 TFLLFVAFFLVVAFRFIVVPtGPSsTHQELIFDV--TSSA-----------------------PVASASFlseekraylr 102 Micromonas ...
EEC46725          88 GLLLTVSLASYWMCYQAAMP-SRH-SSKLLYFDY--TGSALprlmaakvpfrpvedsessyqgPWALVDLfskqphweaf 163 Phaeodactyl...
XP_002286702      63 IALLILSMGTYWLIYWGVIMrGLEvRSRPIFFDY--SVGESi--------------------mPMGRVDLrstrnapwiq 120 Thalassiosi...
XP_001746817      46 HVMLGAGVVIYGLFYYAYVP-KAA-YEWPVHLTQ--TGAE-----------------------PLASI------------ 86  Monosiga br...
XP_004995916      58 AVCYAASVFIYGVTYWWIVP-EPE-HSWPLYFDY--GSKGGq--------------------rPLTHVYLs--------- 104 Salpingoeca...
6DS5_A           106 -----------------------------------grD-------------------RVLMYGQP---YRVTLELELPES 128
EGG21824         158 -------------------------------------A-------------------VSFQRSQL---YDIYLNLEMPES 178 Cavenderia ...
EFA81096         114 -------------------------------------A-------------------VEFQRNKL---YDVYLHLELPES 134 Heterosteli...
Q54K07           118 -------------------------------------A-------------------VEFQKNKH---YNIYLELELPES 138 Dictyosteli...
jgi:MICPUN_63945 106 lyd----------------------npklitdaaltsS-------------------RVLTPGQR---FDVSVSLTLPET 141 Micromonas ...
EEH53274         103 spaaftk--------------ptadapatisdkalrrA-------------------RVLDPGTR---FDVTATLVVPDA 146 Micromonas ...
EEC46725         164 s--------------------------heilpppttsT-------------------RLLQPKQD---YYIEIVLDLPES 195 Phaeodactyl...
XP_002286702     121 scdnslasshlstselcmnedkrqvvvldnpnayckeStgscatlgeaeatntptkeSILIQGQH---YFLEVVLILPES 197 Thalassiosi...
XP_001746817      87 ---------------------------------------------------------VPLSPYTGgptHT-------PTS 102 Monosiga br...
XP_004995916     105 ------------------------------------hDt-----------------rHALRVGQA---YDFTVELELPNS 128 Salpingoeca...
6DS5_A           129 PV------NQDLGMFLVTISCYTR-GGR---------------------------------------------------- 149
EGG21824         179 PK------NEDMGMFMVCLDLDSQdKWNp--------------------------------------------------- 201 Cavenderia ...
EFA81096         135 PK------NEAAGMFMACLEIENQdKWNp--------------------------------------------------- 157 Heterosteli...
Q54K07           139 PK------NQDIGMFMACMDIDDHdKWNp--------------------------------------------------- 161 Dictyosteli...
jgi:MICPUN_63945 142 RH------NVDAGVFQVRAELLTA-RGE---------------------------------------------------- 162 Micromonas ...
EEH53274         147 AAaatgagGVDGGMFQVYASLTNE-RGD---------------------------------------------------- 173 Micromonas ...
EEC46725         196 EH------NQMLGMFGVVTELYSR-NGT---------------------------------------------------- 216 Phaeodactyl...
XP_002286702     198 EI------NKQVGVFMLTVDLLSDkKQ----------------------------------------------------- 218 Thalassiosi...
XP_001746817     103 VL------SARTGSFTATCHLLYSlEQAfelpteatplgtpfpalsgkssetqqsapptaqpgplapstaivtsqawhla 176 Monosiga br...
XP_004995916     129 RP------NRQAGMFMVSLWLSSTkDDAhashdialhqge---------------------------------ltatgnl 169 Salpingoeca...
6DS5_A           150 ----IISTSSRSVMLHYRSDLLQMLDTLVFSSLLLFGFAEQKQ--LLEVELYADYRENSY---VPTTGAIIEIHs----- 215
EGG21824         202 ---hKLLSVCRPATIKYRSPIIKSIKSVLMSIPYIFGLYEEKQ--ELSISLVEDLPFKRF---YQTVSASISILn----- 268 Cavenderia ...
EFA81096         158 ---aKILNTCRPGILKYRSTITKLFRTFTYALTNLFGITEEKQ--IISIPMVENLLSKRF---YQTISVNVNIQn----- 224 Heterosteli...
Q54K07           162 ---qKIHHTCRPAMLKYSSSLLKSLKSIIFSVPYLFGVYEEKQ--IIVLPMGENFVANRF---YQTISASIQINn----- 228 Dictyosteli...
jgi:MICPUN_63945 163 ----VIANATRPAMLAHTGTEVRLLRLLVSWPLHALGLVEEVR--TVTLPMFEGVGERLT---RPFAGVRVTVVprag-g 232 Micromonas ...
EEH53274         174 ----AIANATRPATLKRVNPEVRLLRFVTRWPLYALGLMEETQtqWIRLPMFRGVSEDKS---SPFTSVVVVVKprag-v 245 Micromonas ...
EEC46725         217 ----KLALSRRSMRIPHESHWISVVRKMALLAPLLIGAI-EETr-TVTVPSFRHIVESLD---LPLKYILVQVVmprdpi 287 Phaeodactyl...
XP_002286702     219 ----LLATSIQSSMFPYESRLVGTLRKMTVLLPLVFGMISETR--AISLLCFDNYVDANIersLSFVEVSLGVAqpasfp 292 Thalassiosi...
XP_001746817     177 atapHIHSIRRSAMIPYRSTMVDTLRKALLIVPLTLGLLTESD--TVFIPLFEHFVDDLE---APVQYARIEVSa----- 246 Monosiga br...
XP_004995916     170 veasPGVGGSRPAMLPYRPSIVHFLRRILLAGPYLLGLVDDTQ--TVTVPVMQHV----HvkgRGLHWASVSLSs----- 238 Salpingoeca...
6DS5_A           216 ---KRIQLYGAYLRIHAHFTGLRYLLYNFPMTCAFIGVASNF 254
EGG21824         269 ---KNIQIYSARLSFQAKLSGLEYYMYYYPILSFFIGFCSLF 307 Cavenderia fasciculata
EFA81096         225 ---PDIQIYKASLVFQAKLAGLEYYLYNYPYISFAVGFASLF 263 Heterostelium album PN500
Q54K07           229 ---PEIQIYRASLKFLANLNGFDYYLYYYPITSFIVGCSMIY 267 Dictyostelium discoideum AX4
jgi:MICPUN_63945 233 gpnAVPQMWRAHADLRMDMSALTRFLYHYPASSFAVMVLVTW 274 Micromonas commoda
EEH53274         246 pasALPIIYAAHADVHVEMNALTRAIRSYPASSFVLMSIAVW 287 Micromonas pusilla CCMP1545
EEC46725         288 lasKTVEITGGEIWIGKELNSVQEIMRHWFYTCATLGTAVFA 329 Phaeodactylum tricornutum CCAP 1055/1
XP_002286702     293 atsQTIQILSAELRYGKEMNTIQIFCRNWRYLCAVVGVVVIF 334 Thalassiosira pseudonana CCMP1335
XP_001746817     247 ---PRLQVQSARLIAKANMKGMAYWMYHWYISSFFVGVNAIa 285 Monosiga brevicollis MX1
XP_004995916     239 ---SKLQVTRATLMARTRMQGMTYWMYHWFLSSFVVGTLMLA 277 Salpingoeca rosetta
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