Conserved Protein Domain Family
LMF1

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pfam06762: LMF1 
Lipase maturation factor
This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. The precise role of LMF1 in lipase folding has yet to be determined.
Statistics
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PSSM-Id: 399622
View PSSM: pfam06762
Aligned: 83 rows
Threshold Bit Score: 177.447
Threshold Setting Gi: 122051048
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4N0L2       112 DLLLLEVGFLAIFIfSPFKFFDKHls----------------lDLPSLVKWSFRLLSYRVVLLSGLYKIFl------KLN 169 Theileria parva
CDS42250     122 TSLLIEAGFLCFLL-SIKLRKYSR-------------------SASMIVAWLIKWLLFREAVSTGFARLAndnyfwwDLS 181 Echinococcus mu...
EGT43258     127 DAFLLESTVAVALL-AWFCDG----------------------PPDSIALYGIVLVFLRAIFMNGVTKLQskcpaywSLT 183 Caenorhabditis ...
Q21435         6 DALLLESTVYVAIL-AWFDNG----------------------PADSIALFGIVSLLLRVVFMNGATKLLskcptwwNLT 62  Caenorhabditis ...
XP_003118157 127 DAFLLESTVYVAVL-AWFDDG----------------------PADSVALFSIVALLVRVIFMNGASKLLskcpawwNLT 183 Caenorhabditis ...
CAP30168     127 DAFLLESTVYVAIL-AFFRDG----------------------PADIVAIFGIVVLIVRVTFMTGATKLLskcpewwSLN 183 Caenorhabditis ...
EFA12890     128 DEFLLEAGFLVLLV-APLLPGRRKgsk--------------vlPSDSISFWLVRWLLFRFLLTCGLLKFIsgcpkwwTLS 192 red flour beetle
XP_001950772 128 DELLLEVGLLCILI-APIPFQKLRvpskkrnlr--lqtslaslPHDSIPFWLVRWLLFRVAFSAGVAKMSskssiwyDLT 204 pea aphid
4_pfamImport   2 DILLLETGFLCLLL-SPWRQKGSSassssggskkqaaisnassPADYINFWLVRWLLFRLMFSNAVVKLTsgcptwwSLT 80 
XP_022170379 128 DELLLEVGLLCILI-APLPFQKLRipskkrnlr--lqtslaslPHDSIPFWLVRWLLFRVAFSAGVAKMSskspiwyDLT 204 green peach aphid
Q4N0L2       170 -FQHILTSIPLPTFFAHFLTRAVAKYSFLNTLLTvglLFYEVVLSVFIVTPhRSCRLFGGMALMVYGSVFTLLGNFGPFY 248 Theileria parva
CDS42250     182 aMEHYFSTQISPTPAAYYLSLAPSLVLRIISLFF---IVMEIFIPFLFLIPvRELQIFSFFAKVMFHADLIVIGNHGIYN 258 Echinococcus mu...
EGT43258     184 aLDYYFESQPLPTVFAWHAHQLPPYIKQVASLVM---HYCEIILPAFFLIPlKHVRYVAFFGQVLLMSANILTGNGGYLY 260 Caenorhabditis ...
Q21435        63 aLNYHFESQPLPTPFAWYAHYFPQFFKQLATLQM---NFIEILLPPLFLIPlIHVRYFVFFCQVLLTTLTLFTGNNGFFN 139 Caenorhabditis ...
XP_003118157 184 aLDYHFESQPLPTPFSWYAHHFPPFFKQLATIAI---YYFEIILPPLFLIPvIHVRYVVFFCQILLMILTMLTGNNGFFN 260 Caenorhabditis ...
CAP30168     184 aLDYHFESQPMPTPLSFYAHHFPSFLKQAATLAT---FCFEIALPCMYMIPvIHVRYVMFFGQFLLTTLTILTTNNGFMN 260 Caenorhabditis ...
EFA12890     193 aFNYYFETLPLPTPLSWYFHQIPSWYLKLFGVIA---NVCEIGIPFLFFVPiRAVRITSFMIQIFLQISIVLTGNYNFTN 269 red flour beetle
XP_001950772 205 aLSKYFESMPLPNAISWYAHYFPLWFLKTITVFA---EINDLFVPLMFLVPiRSVKKLAFYIQVFMQVGILASGNYSYYN 281 pea aphid
4_pfamImport  81 aLNVHFESMVIPTPIAWYFHHLPLWILKLGLAYS---FFAEIFVSPLFFCPiKGVRTTAFFIQVFLQLMIIISGNYNFFN 157
XP_022170379 205 aLSKYFESMPLPNAISWYAHYFPLWFLKTITVFA---EINDLFVPLMFLVPiRSVKKLAFYIQVFMQVGILASGNYSYYN 281 green peach aphid
Q4N0L2       249 ILLLLTSLFCLDDqflhpftqwkfnpfaksdtlmkkvsidliesltnsgdsvesvenvenedpvdtvesvdnvdnvlecn 328 Theileria parva
CDS42250     259 LLSIVLSFALLPEpkryk-------------------------------------------------------------- 276 Echinococcus mu...
EGT43258     261 YNILVLLISLLGspnl---------------------------------------------------------------- 276 Caenorhabditis ...
Q21435       140 YNILVLMVSLLQtprv---------------------------------------------------------------- 155 Caenorhabditis ...
XP_003118157 261 YNVIILLVSLLEtprv---------------------------------------------------------------- 276 Caenorhabditis ...
CAP30168     261 YNVLVLLVSMLEiprv---------------------------------------------------------------- 276 Caenorhabditis ...
EFA12890     270 LLMVTLLLSLLDDqffygrrk----------------------------------------------------------- 290 red flour beetle
XP_001950772 282 LLYIVLCLSLLDDhtfyrela----------------------------------------------------------- 302 pea aphid
4_pfamImport 158 FLIFALCFSLLDDdffygegkk---------------------------------------------------------- 179
XP_022170379 282 LLYIVLCLSLLDDhtfykela----------------------------------------------------------- 302 green peach aphid
Q4N0L2       329 tvrseecteetfgsvyiERILSNLSYnrhrEYL-RDFMNLDNLSVSeLFK--Kii---------------tDLLfllylt 390 Theileria parva
CDS42250     277 ------------gssvsHRFVSVATTvavlTVLfYGVWVFFGFQEGieamritilrkefidqaktvnyytiLIV------ 338 Echinococcus mu...
EGT43258     277 -------------nisiAPFLSGLVF----GKMiYDVLHGSPIEIIiGES--Khivltitq--nvfqkfvaWSV------ 329 Caenorhabditis ...
Q21435       156 --------------pigASFLAAIVF----AKIgFEVVYRLPYKILfEDD--RlpsfaltlthesfrkfmiYYI------ 209 Caenorhabditis ...
XP_003118157 277 --------------pvgAPLLSALVF----GKLgYDLAHRMPVKLVtTEG--SlpsfvlnlsydtfqklaiYYI------ 330 Caenorhabditis ...
CAP30168     277 --------------pqgEPFLSMLIF----ARIaYDVIYKGRFKIItEVG--SwptftldmnyesfqklvrYYI------ 330 Caenorhabditis ...
EFA12890     291 ---------pftkwtfiEKVINILTY----GALlLAVVKLYSLKLD--GT--Iiesniaftk-dqfeyvlkQGL------ 346 red flour beetle
XP_001950772 303 ---------lartrqwcSTVFTRLMTinviTVLiAVFPMLYNFRISpANT--Pdftiafth--qqfnvilgKSL------ 363 pea aphid
4_pfamImport 180 ---------stalkrfsKYLATIIIY----TVViFAFIKLYGIKIT-PAG--Iieskisfkp-sdfdvslgRAV------ 236
XP_022170379 303 ---------lartrlwcSTVFTRLMTinviTILiAVFPMLYNFRISpANT--Pdftiaftq--qqfnvilgKSL------ 363 green peach aphid
Q4N0L2       391 vilvlllllllfphykgVKSLILFLVCVLLKSHceavrtkisllqgeytlfllqsilifemvkngpntwsfllwigltel 470 Theileria parva
CDS42250     339 -----------------SSFFVLNLLAAMFRSLstrgcmnrmldftgvalvglm-------------------------- 375 Echinococcus mu...
EGT43258     330 -----------------EIMTVLMFFMLSLIGVta--------------------------------------------- 347 Caenorhabditis ...
Q21435       210 -----------------DVIVATMAIIFTIVNCysmlkvgssqngrmkkwvhlafvlcs--------------------- 251 Caenorhabditis ...
XP_003118157 331 -----------------DMIIILTALMFSIINAytvlkglgsqarvskivhvafvaacv--------------------- 372 Caenorhabditis ...
CAP30168     331 -----------------DLLVIIIIIMLAVTILrailqsclstdkfskmfhvafvastv--------------------- 372 Caenorhabditis ...
EFA12890     347 -----------------TITIYLGLISLAVTILralsislfdvqgskvftiittilys---------------------- 387 red flour beetle
XP_001950772 364 -----------------PFIAYFALGSFVFECLkalysslplksktdgslsalitstly--------------------- 405 pea aphid
4_pfamImport 237 -----------------PILAALAFCSLAFTCLrslalvfsqtgttvskvmslfstlfyi-------------------- 279
XP_022170379 364 -----------------PFIAYFALGSFVFECLkalysslplksktdgsfsalitstly--------------------- 405 green peach aphid
Q4N0L2       471 qlnlskkmdnmhhltkmiiqsflfihlivfsvrvfqhsvteiltpqsnnirsvnintmsnintmsnINTMSNintISSGM 550 Theileria parva
CDS42250     376 ---------------------------------------------ggglfaaslapfsslvdsssvVPLPSFayeLTAAL 410 Echinococcus mu...
EGT43258         --------------------------------------------------------------------------------     Caenorhabditis ...
Q21435       252 -----------------------------------------vlflgvygnipllrmdeklaqrtyepPVVMT---MYKTV 287 Caenorhabditis ...
XP_003118157 373 ------------------------------------------lllniygsvpllrmdeklaqrtnenPMIMS---YYKIA 407 Caenorhabditis ...
CAP30168     373 ------------------------------------------vilsvygfipllrldeklatktnenPIIMT---YYAAA 407 Caenorhabditis ...
EFA12890     388 -----------------------------------------giavllffastvplaslhtasnstvHPSVRT---VYNRL 423 red flour beetle
XP_001950772 406 ----------------------------------------vsiclgifslssvnfsalhqsvnntvPKDLKL---FYNKL 442 pea aphid
4_pfamImport 280 ----------------------------------------ftalalfsdslvpfsnlhpatenttvHPEIRQ---FHNKL 316
XP_022170379 406 ----------------------------------------vsiclgifslssvnfsalhksvnntvPKDLKI---FYNKL 442 green peach aphid
Q4N0L2       551 NNFYSVSNYRNVFRVGR--------DRYELVIEGTNESVvttrtHWEEYYFKRKPSKLDQFPH-LTPfYQYFLDDILvqs 621 Theileria parva
CDS42250     411 KPFHLANDYRFFHQKEKdvllkvdrQRTVLVLEGAMNENg----PWKELSFHHVPSTPEKMPS-VIPgHLPVVDFEA--- 482 Echinococcus mu...
EGT43258     348 ------------vKMTGi------yGRPEIVIEGATNIEg----PWKEISFSSKPGNVSRRPDyPRP-GYHRLDMQM--- 401 Caenorhabditis ...
Q21435       288 NSWSVANSYGSYRQMTGt------hGRPEIVIEGSHHIEg----PWREIEFTSKPGKVSKRPRfISP-HHPRLDMQM--- 353 Caenorhabditis ...
XP_003118157 408 NSWSVANPYGTYRHMTGq------hGRPEIVIEGAPNFDg----PWKEIEFKAKPGSISRRPDfVSP-HHPRLDAQM--- 473 Caenorhabditis ...
CAP30168     408 NKWGVANSYGSYRQTTGk------fGRPEIVIEGSHQVEg----PWKEIGFKVKPGLLSKRPQfVSP-GHPRLDVQM--- 473 Caenorhabditis ...
EFA12890     424 HKLHAVNQYGLFPKMMGv------dGRPEVILEGSDNVEg----PWLEYNFLYKPGNVNHSLPfVAP-YSPRLDWQM--- 489 red flour beetle
XP_001950772 443 APYKISNSYLPPKEFINl------eNRKEIVIQGASDIKg----PWYEYQFLYKPGNVNVTPPiIAP-YKPLLDRQL--- 508 pea aphid
4_pfamImport 317 SHLHLTNSYGLFRRMTGv------gGRPEVIIEGANNLEg----PWVEYHFKYKPGDVNTTLPfVAP-HTPRLDWQM--- 382
XP_022170379 443 APYKISNSYLPPKEFISl------eTRKEIVIQGASDIKg----PWYEYQFLYKPGNVNVTPPiIAP-YKPLLDRQL--- 508 green peach aphid
Q4N0L2       622 fnlqynnsnsnsnsssnrnnrnsvrkkkyvvttgdtgdtgdtvegtgdsvdrvngdelpyAVTEK-------FIFDLLRM 694 Theileria parva
CDS42250     483 ------------------------------------------------------------ALSGertfenspIVATLVYR 502 Echinococcus mu...
EGT43258     402 ------------------------------------------------------------HYAAEgtyqqnpFFLSLIYH 421 Caenorhabditis ...
Q21435       354 ------------------------------------------------------------YYAAEgtyqqnpFFLSLVYH 373 Caenorhabditis ...
XP_003118157 474 ------------------------------------------------------------YYAAEgtyqqnpFFLSLVYH 493 Caenorhabditis ...
CAP30168     474 ------------------------------------------------------------HYAAHgtyqqnpFFLSLVYH 493 Caenorhabditis ...
EFA12890     490 ------------------------------------------------------------FWAAYntydkqpWILSLTHR 509 red flour beetle
XP_001950772 509 ------------------------------------------------------------FFAAHslpaqnpWLMSVLYR 528 pea aphid
4_pfamImport 383 ------------------------------------------------------------WFASLgtyhqnsWIMSLTYR 402
XP_022170379 509 ------------------------------------------------------------FFAAHslpaqnpWLMSVVYR 528 green peach aphid
Q4N0L2       695 LLMGSGEVKNLM---YNPFeGT--KPKYTRVLLYKYYFSNlhsgnsNTRsKNWYYRNLVTEL-IP 753 Theileria parva
CDS42250     503 ILTKEKEVLALLe--PSGFp---iGPKFVQIRKYTYEISR------SINgPQWWKRKLQNIY-LP 555 Echinococcus multilocularis
EGT43258     422 LMQNNSEVVGLLd--HHPFqNRsePMNFARAKLYMYHFTKe------gE-TDWWRRDFQEEY-MP 476 Caenorhabditis brenneri
Q21435       374 LMQNTTEVVNLIe--DYPFkNRsePMRFARAKLYMYHFTDi------gD-KNWWTRSFQEEY-MP 428 Caenorhabditis elegans
XP_003118157 494 LMQNTTEVVSLIe--NYPFkNRsePMQFVRAKLYMYHFTDi------gD-KNWWRRDFQEEY-MP 548 Caenorhabditis remanei
CAP30168     494 LMQNTTEVVGLIe--DYPFkNRsePMKFVRAKLYMYHYAKm------dD-KNWWTRDFQEEY-MP 548 Caenorhabditis briggsae
EFA12890     510 LLTGKAEVLALLdrhHSPF-NQk-PPKYIRGILYKYKYSSws---qRSQ-PSWWVRQKVGEY-FP 567 red flour beetle
XP_001950772 529 LLNNQKEVLSLLntnQIPF-GKn-PPKFVKVSLYKYQFSSkl---qRER-GVWWNRQILNSEfIA 587 pea aphid
4_pfamImport 403 LLTGSKEVLALMdvqRNPF-PVk-PPRYITASLYHYSY-Tpwk-srDKP--ATWTRKKVGEY-FP 460
XP_022170379 529 LLNNQKEVLSLLntnQIPF-GKn-PPKFVKVALYKYQFSSkl---qRER-GVWWNRQILNSEfIA 587 green peach aphid
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