Conserved Protein Domain Family
A24_N_bact
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pfam06750: A24_N_bact (This model is not part of the current CDD release)
Bacterial Peptidase A24 N-terminal domain
This domain is found at the N-terminus of the pre-pilin peptidases (pfam01478). Members of this entry have been characterised as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and four almost fully conserved cysteines which bind Zn, as described for PilD from Pseudomonas aeruginosa. The cysteines have been shown to be essential to the overall function of the enzyme.
Links
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Statistics
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PSSM-Id: 517403
Aligned: 335 rows
Threshold Bit Score: 68.2512
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012345585  20 VIGLCIGSFLNVVVHRLPLmlerqwlgdvqamlqdsaglqrtlgagidaaavqhlhdggerlgsalaslpaL-SLS-RP- 96  Leptothrix chol...
Q8Y6Y1         8 iYSAVFMSFIQVAGECFPVkks-----------------------------------------------flF-------- 32  Listeria monocy...
Q5HNP1         6 yTCSIIFSFLYQFCNQ--N----------------------------------------------------IlKLQyLYs 31  Staphylococcus ...
Q2FXS1         7 ysCSCIFSFLYQFISI--E----------------------------------------------------EtSFDyLHr 32  Staphylococcus ...
WP_014261898  11 yIGTCFGSFYNVVIDRLPR----------------------------------------------------EiNFV-HG- 36  Filifactor alocis
WP_014163656  11 mIGASMGSFLNVVARRtiendr-----------------------------------------------------wwgne 37  Thermovirga lienii
WP_022358950  18 IFGCAIGSFTDCLAGRM-La---------------------------------------------------GtSIL-KG- 43  Clostridium sp....
CCX67306      22 VLGAIFGSFLNCMAWRM-Vy---------------------------------------------------HeSVL-KG- 47 
8_pfamImport   1 VLGACLGSFVNCLAWRL-An---------------------------------------------------GeSVL-AG- 26 
WP_006655827   8 IIGAIFGSFANVLIFRIPQ----------------------------------------------------NmSII-LP- 33  Helicobacter ca...

WP_012345585  97 R-SRCPACGTQLGWHHNLPILSWLALRGRCAACRAPISRRYPLVEAGTALAFGLIGWVF 154 Leptothrix cholodnii
Q8Y6Y1        33 RfSECNYCQKKLAFYHIIPIFSFLFFRGKSRCCERPIPIIYFLMELVTPIYILLLYIQF 91  Listeria monocytogenes
Q5HNP1        32 R-SHCDFCHTIIKPLDLLPIISFLKLRGQSRCCNQPLQRLYLIGELVSF---GAIFLYY 86  Staphylococcus epidermidis RP62A
Q2FXS1        33 R-SKCDYCNSSLKWYELMPIISFLLLKGRCRNCRKRISLTHFLGETFALIPIVFIKYDF 90  Staphylococcus aureus subsp. aureus ...
WP_014261898  37 R-SYCPSCKHSLSTVDLFPIISFLFLRGKCRYCKTSIPIRSLLIEILSGLLFFLSFYKY 94  Filifactor alocis
WP_014163656  38 R-SRCDHCGHELSFWDLVPLFSYISHGGKCRYCSEPIGASYLIVELTGFLIGAVLAWRW 95  Thermovirga lienii
WP_022358950  44 R-SHCDACGHVLGVPDLVPLFSWLCLRGRCRYCGAKIPAESFWAELVSGIACCLIVYRF 101 Clostridium sp. CAG:43
CCX67306      48 R-SHCASCGHPLKAADLVPVFSYLFLKGKCRYCGEKISPRYMAAELVSAALWLGCVFRY 105
8_pfamImport  27 R-SHCTSCGHVLGALDLVPVASWLALRGRCRHCGQRVSPRYVIVEALVAALFAAVVARY 84 
WP_006655827  34 F-SFCPRCKKSLGFMDKIPMVSYLILGGKCRYCGEKIPKWYLLGEVLGGIFGVFSFYCF 91  Helicobacter canadensis
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