Conserved Protein Domain Family
FAST_1

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pfam06743: FAST_1 
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Statistics
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PSSM-Id: 429093
Aligned: 116 rows
Threshold Bit Score: 45.5583
Threshold Setting Gi: 780028080
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDV27484            373 LCQLIYSLGKMNFKLElpasK--KFFPIVIQRLEDLMKrqnRYTPKFykqVISATWSLIIMEQFPPRLISKILSDQFIED 450 Trichopl...
XP_011258312        286 YSSILQTFAALQFKSE----KasTFIKSFTEQSDPSCV---S--ASE---WLDIAWSLAVLDAASPQHIKFILDPTFMEN 353 Florida ...
XP_011066682        297 YSSIIQTFAALQYKSQ----KtnLFLEKFTEYISPFET---S--WIE---WLDIIWALTVLDVVKPQHIQNLLDPLLMEK 364 Panamani...
Q7PYQ7              200 LGSLLLSLATLNYEPI----SmdTIKAKLVANVSENDF---IR-STD---WLNTVWSLTILNCVSGEQLSSVLNADFFRR 268 Anophele...
EDS39098            325 MSALFLSLATLNHEPS----NmdAVKTKLVANLSESDF---IK-STD---WLNMVWSFAVLNCASSKHLASVLKPSFVGC 393 southern...
XP_002000697        335 LSAYFLTSALLNFKSA----HleDVRNKLAKSIVREDF---TK-QSD---WLNFVWSLTLLGIVENSQINSVLSTEFLTK 403 Drosophi...
WGS:AAQB:GK12980-PB 326 LSAYFLTSALLNFKSS----QieEVSKSLVKSIVRDDF---TK-QSD---WLNYIWSLTMLGIVDHSQLESVLNEEFLQK 394 Drosophi...
XP_002032192        318 LSAYFLTSALLNFKSA----QleEVSKKLVQSIVREDF---TK-QSE---WLSFVWSLTMLGLVEHGHLASVLSADFLET 386 Drosophi...
XP_002054379        338 LSAYFLTAAQLNFKSA----HleDVRKKLAKSIVREDF---TK-QLD---WLNYVWSLTMLGLVEHSQLESVLRADFLAK 406 Drosophi...
XP_015791615        349 LVAFVLASAKLNFYPD-------YLDELLKKRIFPEIN---QKSIKDsfiWLDFVWSLVIMNLVPAASIESIFNQSFIHS 418 two-spot...
EDV27484            451 AT 452 Trichoplax adhaerens
XP_011258312        354 LI 355 Florida carpenter ant
XP_011066682        365 NA 366 Panamanian leafcutter ant
Q7PYQ7              269 LQ 270 Anopheles gambiae str. PEST
EDS39098            394 LE 395 southern house mosquito
XP_002000697        404 LE 405 Drosophila mojavensis
WGS:AAQB:GK12980-PB 395 LE 396 Drosophila willistoni
XP_002032192        387 LK 388 Drosophila sechellia
XP_002054379        407 LE 408 Drosophila virilis
XP_015791615        419 LK 420 two-spotted spider mite
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