Conserved Protein Domain Family
FAST_1
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pfam06743: FAST_1 (This model is not part of the current CDD release)
FAST kinase-like protein, subdomain 1
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 517399
Aligned: 102 rows
Threshold Bit Score: 44.0115
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002109318  373 LCQLIYSLGKMNFKLElpasK---KFFPIVIQRLEDLMKrqnRYTPKFykqVISATWSLIIMEQFPPRLISKILSDQFIE 449
XP_015212779  381 LCNLLMAFARLNFQPS----Kd-vAFYSKVHAGLEGALT---QLEPFL---QTDVVWSLCILQQARPQDLRPVLEPGFQS 449
23_pfamImport   1 LCNLLMTFARLNFQPS----Kk-eEFFSKVHTALEDSLP---GMEPFL---QTDVVWALCVLQQAKPHYLIPLTKQSHIS 69 
XP_003450964  375 LCNLLMTFARLGFQPS----Kg-dEFFNKVHSVLEKALS---GLEPFL---KTDVVWSMCVLQQAKPHYLIPLIQQNHVS 443
XP_020565820  373 LCSLLMTFARLGFQSG----Kg-eEFFSKVHVVMEDSLA---SLEPFL---QTDVAWSLCVLQQAKPHYLTPLIQESHVQ 441
XP_005804728  373 LCNLLMTFARLGFQPS----Kg-eEFYRKVHVVLKESLA---SLEPFL---QTDVVWSLCVLQQAKPDYLVPMTQTSHVT 441
XP_008260053  370 LCSLLLAFARLNFRPE----Re-eEFFSLVHERLGPALA---SLEPAL---QVDLVWALCVLQQVREAQLHAVLRPGFHS 438
Q91YM4        367 VCSVLLAFARLNFHPE----QeedQFFSMVHEKLDPVLG---SLEPAL---QVDLVWALCVLQHVHETELHTVLHPGLHA 436 house mouse
XP_006911544  365 LCNMLLAFARLNFRPE----Le-dRFFSLVHEKLEPELA---RLDPGL---QVDVLWALCVLQQAREAELQAVLRPEFHR 433
XP_003762603  364 LSNMILTFARLNFHPE----Qe-eQFFSLVHKKLESELD---KLSPGL---QVDVVWSLCILQQVQKKQLQEVLCQDFHN 432

XP_002109318  450 DAT 452
XP_015212779  450 RLT 452
23_pfamImport  70 KLS 72 
XP_003450964  444 KLS 446
XP_020565820  442 KLS 444
XP_005804728  442 NLQ 444
XP_008260053  439 PLL 441
Q91YM4        437 RFL 439 house mouse
XP_006911544  434 QFL 436
XP_003762603  433 QFL 435
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