8ESR


Conserved Protein Domain Family
Pescadillo_N

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pfam06732: Pescadillo_N (This model is not part of the current CDD release)
Pescadillo N-terminus
This family represents the N-terminal region of Pescadillo. Pescadillo protein localises to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.
Statistics
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PSSM-Id: 517392
Aligned: 34 rows
Threshold Bit Score: 322.275
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8ESR_n         6 QKGKAGAARIYITRNQALKKLQLTLADFRRICILKGVYPREPKN-KKKANKGStapVTFYYTKDIQYLLHEPIVQKFREY 84  fission yeast
Q7R7N4         8 AKIKKKHQEKYLTKKKIQKKLFLNESEFRRLCIFKGIYPKDYKDiPLKFRNKFyknKVYYTRNDYKKLSNEKIIQDFRKI 87  Plasmodium yoel...
XP_001347765   8 KKIKKKKEGKYLTKKHILRKLFLNEEEFRKLCIFKGIYPKDFKEiPLKYRKKFykhKVFYTRNDFLKLSHEKIINDFRKI 87 
XP_006833187   9 GKKREGNSAKYITRTKAIHYLQINLSSFRKLCILKGIFPREPKK-KLEGND-----KTYYHMKDIMFLAHEPLLEKFREI 82 
A0DEJ7         6 KKGKEGPVKEYVSRTKALKKLQVNLKDFRRLCILKGIYPREPPQ-KLRKQH-----KTYYHNKDIAFLKNESILDTFRQR 79  Paramecium tetr...
Q23RV6         6 MKNTRGEATKYISRAKAIKKLQVSLKDFRRLCILKGVYPREPPK-KLQKQN-----KTYYHLKDINYLMHEKILNKFREL 79  Tetrahymena the...
XP_004034468   6 MKNTVGEATKYISRAKSIKKLQISLKDFRRLCILKGVYPREPPK-KLFKTG-----KTYYHKKDINYIMHEKILQKFREQ 79 
XP_020433855   8 KKNEKGENIRFITRNAAARKLQISLKLFRKLCIIKGIHPRDPKK-KLQGKH-----KTYYYMKDIRFLQHEPIIQTLRDR 81 
Q54HJ2         8 KKGEKGENLKFITRNEAVKKLQISLKIFRKLCILKGIHPRDPKK-KFKGKH-----KTYYYSKDIKYLQNEKVLEIIRAR 81  Dictyostelium d...
XP_003286686   8 KKGVKGENLKFMTRNEAVKKLQVSLKVFRKLCILKGIHPRDPKK-KLKGKN-----KTYYYAKDIKYLQNEKILETIRER 81 
8ESR_n        85 KVFARKLSK-ALGKGELETAKRLEARKPTYSLDHIIKERYPTFHDALKDIDDALSMLFLFSTMP--VTDKIGAATVANCE 161 fission yeast
Q7R7N4        88 KTSLKRYKKyKITLEDNERCKNIIKNFPKYKLDHIIKERFPILVYAVEQLNDALTAIIAYSFLPsnENIGIKNNLINQSI 167 Plasmodium yoel...
XP_001347765  88 KIYLKKYKKcKLTLEDFTRSKNIVANFPVYKLEHIIKERYPILSYAVDHLDDALSCIIAYSQLPsnHKYGIKNNMVKTCE 167
XP_006833187  83 RAYDKKIKR-ALAKKNKDEVARLEKNRPSYTLDHLVKERYPQFVDALRDLDDCLTMIHLFAALPavESERINVNRIHNCR 161
A0DEJ7        80 QAHLKKIRK-ALTRGDKLKAGRLRRNQPKDKLDHLVKERYPTFIDALNDLDDPLCLVSLFASFPthKELHIPNTLIRGCQ 158 Paramecium tetr...
Q23RV6        80 KTHMKKVMK-LKAKGDKTRLRLLQKQKPTYSLNHLVKERYPTFIDALRDLDDPLCLVNLFASFPahKALGVPRDSITKCI 158 Tetrahymena the...
XP_004034468  80 KAWAKKLQK-LKARKDEMRVKKLLKDKPTYTLNHLIKERYPTFIDALRDLDDPLCLISLFSCFAahKSLGVKRNIVEKCI 158
XP_020433855  82 KTFAKKEKK-LRERKDWAALEQFIKNRPSSSIDHIVRERYPTFTDALKDLDDCLTLIHLFASMD--SSPKLRENHIVTCA 158
Q54HJ2        82 KVFKDREKK-LINKKQFGALKNLKENRPMITLDHIIKERYPTFQDALKDLDDCLSLIHLFANMD--ASAKVRENQILACE 158 Dictyostelium d...
XP_003286686  82 KTIKEKEIK-LIAKKEVALLKKLRENRPMISLDHIVKERYPTFEDALKDLDDCLSLIFLFANMD--ASPKIRENQIRACE 158
8ESR_n       162 RLCAEFQHYVIRSNSLRKAFLSIKGIYYQAEIFGEQITWIVPYKFAQSVPTDVDFRIMHTFLEFYQALMGFVNFKLY-NT 240 fission yeast
Q7R7N4       168 ILRNH-----------------VKGYYLQAEILQKKITWLIPHIFTPYFDKSIDFKIITNFIEYYVTLLRFILYKLY-RL 229 Plasmodium yoel...
XP_001347765 168 MLKDHFHYYVYKTNRIKKAFISVKGYYLQAEILKKKVTWIIPHIFTPYLDTSIDFKLISDFIEYYIALLKFVLFKLY-KL 246
XP_006833187 162 RLSHEWQAYISRTHSLRKTFISVKGIYYQAEVQGQKITWLTPHALQQVIPDDVDFNVMLTFLEFYETLLAFANFKLY-HS 240
A0DEJ7       159 KLLSQFLLYVSANNCLRKVFLSIKGIYYQAVVQGATITWIMPYPIQASLPLDVDYKIMMTFLEFYQVLMKFVNFKLLgQD 238 Paramecium tetr...
Q23RV6       159 KLMREFNLFVIKSKSLRKVFISIKGIYYQAEIEGQKITWIAPFQLPAELPAEVDYKVMLTFLEFYETLIKFVNFKLF-NS 237 Tetrahymena the...
XP_004034468 159 RLQREFNLYIIKSRSLEKVFVSIKGIYYQAQIEGQKITWIQPFQLPAELPVEVDYKVMLTFLEFYEILVKFVNFKLF-SN 237
XP_020433855 159 DLCREFQHYVTVSKSLKKVFVSIKGIYYQAEIMGETITWLTPINYINKKEKKVDYGVMINFLEFYEVMLKFVNYKLY-TS 237
Q54HJ2       159 RLAREFQYYIIQSKSLRKVFVSVKGVYYQADVMGETITWITPLNYLSKKEKEVDYGVMISFLEFYQALMKFVNYRLF-TS 237 Dictyostelium d...
XP_003286686 159 KLAREFQYYVAKSNSLKKVFVSVKGIYYQAEIMGETITWITPLNYLSKKEKQVDYGVMISFIEFYQALMKFVNYRLF-SS 237
8ESR_n       241 LGLRYPPKID-VAKSESAAGLAAYE----LEESSSLPA------I 274 fission yeast
Q7R7N4       230 DGMSYPPK---EYKDLKNEKLNHLS----FDKNYITKE------L 261 Plasmodium yoelii yoelii
XP_001347765 247 DNMLYPPK---QDNDLKNEKLAHLS----YDKDYSTNEnnidinM 284
XP_006833187 241 INVKYPPTLD-PRLEALAADLYALSr--yLAASSRTLL------L 276
A0DEJ7       239 IEI--------TDFSEEVKKLKSVSqnnqIEIDEAFKEdptiqqM 275 Paramecium tetraurelia
Q23RV6       238 INVKYPLEINkSIEDQSYFSYSSFV----LKHKDSQQT------I 272 Tetrahymena thermophila SB210
XP_004034468 238 LGIKYPITINqSIEDQSYFSYSSFV----LETKDSQQT------L 272
XP_020433855 238 LGLKYPPTID-KSRLNNGEHLSSI-----LTEKLNKTS------T 270
Q54HJ2       238 IGLTYPPTID-DAKLRKCDSLINI-----FESKPQQQT------K 270 Dictyostelium discoideum
XP_003286686 238 LDLEYPPKID-EIKLGKAEGLFNI-----FDSLKTKTA------I 270
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