Conserved Protein Domain Family
BC10

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pfam06726: BC10 
Bladder cancer-related protein BC10
This family consists of a series of short proteins of around 90 residues in length. The human protein BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs). The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript. All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues. The function of this family is unknown.
Statistics
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PSSM-Id: 369052
View PSSM: pfam06726
Aligned: 11 rows
Threshold Bit Score: 52.0426
Threshold Setting Gi: 50401792
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
YP_918990      1 MLRLHFNKSNGIYSVRdSGRSLVKATEKHAViPKVLGATIELAPRVHAVITTGLFKEATTgsRPFIPVL 69  Yersinia phage Berlin
Q5BS74         1 MFCLQLLIPLLFLPKP-SNPAADIHHAIYIL-LFLICFFLERKPCGICAIILFVFIILPC--YSSLDNF 65  Schistosoma japonicum
Q7PNT1         1 MYCLQCLIPVLLIPKP-TNPALMQTHVMFIV-LYLIGFFLERKPCTICSLVFLMAVFLIC--NSGVGNC 65  Anopheles gambiae str. PEST
XP_003904818   1 MYCLQWLLPVLLIPKP-LNPALWFSHSMFMG-FYLLSFLLERKPCTICALVFLAALFLIC--YSCWGNC 65  olive baboon
Q8MXX3         1 MYCLQWLLPVLLLPCP-ANPALYWNHFMFLG-LYLTSFYVKHRPCIICSLVFFITMFMIS--YSNCHLF 65  vase tunicate
Q7SBZ2         1 MFCLRSWLPLLFIP--------TNASPAFIL-VFFICTYFLNRPCIYCSFLLVILFLT----SCNWSDR 56  Neurospora crassa
EED54958       1 MFCLRSWLPLLFIP--------TNASPLFIV-SFVTLTYILHRPCIYCSALLLILFIS----SCHWSDR 56  Aspergillus flavus NRRL3357
KIS70094       1 MYCLRWWIPLFLLPFP-------KASPLFLV-LFLFSFALHSQPCMYCALILTGLVTT----SPNWYGP 57  Ustilago maydis 521
Q9P6M5         1 MLCLRYFIPMLLVA---------NAAPYFFYpIFMLSMIARKYPCPYCMIILGLLINT----RTLWSDS 56  Schizosaccharomyces pombe ...
Q6WY51         1 MFRLHYNKSVKNFTVRrADRSIVCASECRAK-IPLIGNTVPLAPSVHIIITRGDFEKAIDkkRPVLSVA 68  Enterobacteria phage T7
AEM44580       1 M-RLHFNTSNGIFSVRrEDRSTAVASERNAK-LPLIGSVVPLSPRVHLLITRGEFIKAMNkeRPHLEAV 67  Enterobacteria phage T7M
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