Conserved Protein Domain Family
SPC25

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pfam06703: SPC25 
Microsomal signal peptidase 25 kDa subunit (SPC25)
This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 25 kDa subunit (SPC25).
Statistics
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PSSM-Id: 399591
View PSSM: pfam06703
Aligned: 157 rows
Threshold Bit Score: 39.0992
Threshold Setting Gi: 144578135
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC97366             74 DKLTKQYLADQ-AFTPSHLHATVHLVCGYASCLISLGAFLYTYlkgmSFEESKPYLWIGVIA-----YGAFQ--SALWAW 145 Trichosp...
XP_002258842         31 QDYISEKIRDQ-NFSENIQYSNIRIFLSLLLISIGSYCTIFV-----QYKKEPLLMIKLLIA-----FFIVS--TILFFW 97  Plasmodi...
XP_008074048         28 NDLLVEYLKKEkGYQQRQTYTDMKIAVGLISVVCAILTCYMSLh--yDFADYRKALVVVLAI-----YFSLN--FMLEIC 98  Vavraia ...
EEQ81647             29 DEILVDFLVKDlNYKLNNTYTDFQISVGLLSTVLAALLTYFSMn--fEFKDYKVFMIWCLCI-----YSVLN--GIVYIF 99  Nosema c...
WGS:AFBI:EDEG_00168  28 DDVLGEYLRVEmKYKQSHLFTDLRIFVGLVSTIMSVYLTYLSMn--kEFKEYKYICFVIVGV-----FAVLN--GLLELI 98  Edhazard...
EPR79157             26 NDYLSDYLTFVkqYKKSNLIVDIRNDVGILSTIITLVVLYYSLk--vEFEKAKKIIAWLCAI-----YYIMN--NLLELI 96  Spraguea...
EFC44836             66 DSAVRSILLEEkGFKEDTTLSNIKLIVGFLACGGAVTA---------YFTKNPLYALFLCIA-----YVTVI--FSLTLN 129 Naegleri...
CBI31534             28 DEYVSEIVTSR-GYVEDVRMSNVRLLMGSIIIIIALVAQFYPK----KFPENRDFLIVCILLypfccYILFN--GLLQLI 100 wine grape
XP_002881686         29 DESVSDIVTSR-GYKEDVRLSNLKLILGTIIIVVALVAQFYNK----KFPENRDFLIGCIAL-----YVVLN--AVLQLI 96  Arabidop...
XP_009410061         26 DESVTEVVKSR-GYAEDSRLSNVRLLIGSIIIAIALLAQFYPK----KFPENRDFLIVCIGL-----YVVFNglLQ--FI 93  wild Mal...
EKC97366            146 KR-WVE---------RGEVFRG----------------RRRRVVKrietdliqihtstsllpppepvlsvspnsrpSSPV 199 Trichosp...
XP_002258842         98 EIvFFEdifmilrtnNGGVVKL---------------------------------------------------------- 119 Plasmodi...
XP_008074048         99 LR-FFA---------RNTVFEG----------------YNREG---------------------------------SIRI 119 Vavraia ...
EEQ81647            100 DT-LRGttyyftkviKNNVQED----------------KNDKETEkv----------------------------vSIRV 134 Nosema c...
WGS:AFBI:EDEG_00168  99 LR-VFA---------RGTIFSG----------------KKEDE---------------------------------RICV 119 Edhazard...
EPR79157             97 VW-LRY---------SNMIFMGtknkkvedqkkkksknKKETTES-------------------------------KIRI 135 Spraguea...
EFC44836            130 GY-FFE---------QGTFLLA----------------YSMQYG--------------------------------YVRI 151 Naegleri...
CBI31534            101 IY-TKE---------KNAILFT----------------HPPEGFFns----------------------------tGLVV 126 wine grape
XP_002881686         97 LY-TKE---------KNAILFT----------------YPPEGSFts----------------------------tGLVV 122 Arabidop...
XP_009410061         94 SY-TKE---------KNAILFT----------------YPPAGSFns----------------------------tGLVV 119 wild Mal...
EKC97366            200 DTtsplsspatlkstatqqlngdsgikphpngPTYLVHLTLSTTSnngkslihk-alvvsgkpvGEVVDDNGGVEEGEVT 278 Trichosp...
XP_002258842        120 ---------------------------------FFELDIQKSALVltykmnkq---khstsfelRKLFNEDGFLVQNYAD 163 Plasmodi...
XP_008074048        120 DGfnk------------------------avdTNYKLIIYKNGKAipgnf----------sksiYDLYDESGVLDHETFL 165 Vavraia ...
EEQ81647            135 CTeil------------------------ppnPIYTLLVYKDNKLipekw----------sksvFELFKEDGTLNASQFL 180 Nosema c...
WGS:AFBI:EDEG_00168 120 YSnis------------------------radTNYIVMVYKDGKLipdky----------nkdvRDLFDEDGMLLHKLFI 165 Edhazard...
EPR79157            136 ICsd--------------------------qeNNYEIIIYKNDNIipiky----------hrylGDLFDEKGYFLYEEFT 179 Spraguea...
EFC44836            152 ESdvydedee---------------eaqkrncPKYQISVHFPTLNslfskykassctvhhswyvNDLFDEFGAFDKKEVR 216 Naegleri...
CBI31534            127 SSklp------------------------rfsDLYTLSIASADPKskaakdp-----veftksvTQWFTTDGILVEGLFW 177 wine grape
XP_002881686        123 SSklp------------------------rfsDQYTLTIDSADPKsisagks-----veltksvTQWFTKDGVLVEGLFW 173 Arabidop...
XP_009410061        120 SSklp------------------------rfsDMYTLTIASADPKsisankp-----vvltksvTKWFTKDGVLVEGLFW 170 wild Mal...
EKC97366            279 RWIAGLLG 286 Trichosporon asahii var. asahii CBS 8904
XP_002258842        164 AMLKQFIs 171 Plasmodium knowlesi strain H
XP_008074048        166 REVAQVfa 173 Vavraia culicis subsp. floridensis
EEQ81647            181 DDVtlffn 188 Nosema ceranae BRL01
WGS:AFBI:EDEG_00168 166 EELNYflk 173 Edhazardia aedis USNM 41457
EPR79157            180 NDcdnvfl 187 Spraguea lophii 42_110
EFC44836            217 QAVTDLIK 224 Naegleria gruberi
CBI31534            178 KDVEGLIN 185 wine grape
XP_002881686        174 KDVEALIK 181 Arabidopsis lyrata subsp. lyrata
XP_009410061        171 KDVEKLID 178 wild Malaysian banana
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