Conserved Protein Domain Family
SPC25

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pfam06703: SPC25 
Microsomal signal peptidase 25 kDa subunit (SPC25)
This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 25 kDa subunit (SPC25).
Statistics
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PSSM-Id: 429080
Aligned: 155 rows
Threshold Bit Score: 39.4846
Threshold Setting Gi: 144578135
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC97366         74 DKLTKQYLADQ----------AFTPSHLHATVHLVCGYASCLISLGAFLYTYLKgmSfeesKPYLWIGVIAYGAFQSALW 143 Trichosporon...
XP_003056502     29 DDCLLSFLIDS----------GYVYDHAHDNRKIFLGTFSCTVALLLHFFPELLhcS----KSLTFPILFAYLTLSITLQ 94  Micromonas p...
jgi:OSTLU_92692  19 DDATVCAVLDA----------GYDEDTRTVDAKIALSIAAIGAACAAHAVTMTN-------DATRWACAAAYGALACGAP 81  Ostreococcus...
XP_015623270     30 DETVSEVAKSK----------GYPEDARLSNRRLAVGAAVIAVALLAQFYPR----KfpenRDVLLACIALYAALNVALQ 95  Japanese rice
XP_006652334     33 DETISDVVKSK----------GYAEDTRLGNWKLAIGAAVIAIALLAQFYPK----KfpqnREFLLGCIALYVVLNVVLL 98  malo sina
CBN75563         25 DDAVIKAVLEM----------GYEEDHTLNNAKLAVMALACVFAVTAQFWPQ----PfpesRALLAVCCVSYFACSFCLH 90  Ectocarpus s...
XP_002183401     15 DETVASAILEN-----------IAEDYGWDNFKLGIMALSCVFAMIAQFAPI----PfpesRPVLGVCGALYFALSGILQ 79  Phaeodactylu...
jgi:THAPS_23402  43 DETVAGTITGSedlsahgdkvKILEDYRHDNIKLFLMALACVFASIAQFGLNT---DfpnnRLWLGVCCASYFCLSGILQ 119 Thalassiosir...
EDQ90092         53 EEAFCKATGDAvp-------eeFEQATAEEDFKLIMAAIGCAFAGYACIYGLFV--PhpasSQVVGICAAAYFVFMTILN 123 Monosiga bre...
XP_004345660     71 DDSLRGLLTLEa---------GFIESHRRMDIKIGMSAAAIALTGFALAWGYFV--PfpesSLVVGTCVVLYFALMLVIT 139 Capsaspora o...
EKC97366        144 AWKR-WVE--RGEVfrgrrrrvvkrietdliqihtstsllpppepvlsvspnsrpSSPVDT-TSPLSSpatlkstatqql 219 Trichosporon...
XP_003056502     95 LYSV-YAQmgARMI-----------------------------------------KYDLTAgHSYTSD------------ 120 Micromonas p...
jgi:OSTLU_92692  82 CVAK-YAE--RDALlltrargvdcdgr---------------epaawarnerskdGLTVHV-RCARLA------------ 130 Ostreococcus...
XP_015623270     96 IVTY-TKE--KNAIlftyppa----------------------------gsfnrtGLVISS-KLPRLS------------ 131 Japanese rice
XP_006652334     99 ILSY-TKE--KDAImfthppa----------------------------gsfsstGLVISS-KLPRFS------------ 134 malo sina
CBN75563         91 LIVT-YWE--KDLIlatarss----------------------------srsmgkGIFVRT-DFPRFD------------ 126 Ectocarpus s...
XP_002183401     80 FVTT-FID--KDCIlwtkpadisa---------------------stknkdmhlyGLRIRS-NLPRFS------------ 122 Phaeodactylu...
jgi:THAPS_23402 120 LMMT-FID--KDCImttrpvtdpeaik---------------aiknggnkemdkyGIRVRT-QFPRFS------------ 168 Thalassiosir...
EDQ90092        124 VHAMfFDQ--HAAVlmrsq--------------------------------ktgqRLSTFV-HMNKYS------------ 156 Monosiga bre...
XP_004345660    140 AYTF-FAE--GVTVfeglrqnvsat--------------------arpgsakaqeSVVVDS-EFNKLK------------ 183 Capsaspora o...
EKC97366        220 ngdsgikphpngPTYLVHLTLSTTSNNGKSLIHKal-------vVSGKPVGEVVDDNGGVEEGEVTRWIAGLLG 286 Trichosporon asahi...
XP_003056502    121 ------------KSAWLSFQCKSQKNKEDVTVALtqhghraasiQRELHLCNYLYEDGIFADKKLGGEVRHLLQ 182 Micromonas pusilla...
jgi:OSTLU_92692 131 ------------ETLEVIVSAKSDGKCEAKDAVR-----------CDVRCEEFVTEDGEFLEDEYEALIWRVLE 181 Ostreococcus lucim...
XP_015623270    132 ------------DMYTLTIASADPHSKSSSEPVH-----------FTKSVTKWFTKDGVLVEGLFWKDVEKLID 182 Japanese rice
XP_006652334    135 ------------DMYTLTIASADPQSISANKPVH-----------FTKSVTKWFTKEGVLVEGLFWKDIERLID 185 malo sina
CBN75563        127 ------------EMFTVSAEERKPGSKPIEEQWN---------------VGKYFDYEGNFDEWGMGDAVKKLVt 173 Ectocarpus silicul...
XP_002183401    123 ------------EWYEVILEFQKPKQASASPMVK-----------HTWSIGQFFDKEGYFDEIGLSQEIDKLFK 173 Phaeodactylum tric...
jgi:THAPS_23402 169 ------------EFYTVILEFQGKENSef--------------vKGTWSVGHFFDVDGFFDEEGMQIEIEELYQ 216 Thalassiosira pseu...
EDQ90092        157 ------------PELTVEMILASSAGTSSSQTFD-------------GHVGQFFYEDGEMCREAVVQVTEDLLS 205 Monosiga brevicoll...
XP_004345660    184 ------------HEYTLKITLQRYGKAPVTESLS-------------KPVGSYFHSDGYFAETAFDSDARKLLK 232 Capsaspora owczarz...
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