5YH3,4KQB


Conserved Protein Domain Family
Fam20C
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pfam06702: Fam20C (This model is not part of the current CDD release)
Golgi casein kinase, C-terminal, Fam20
Fam20C represents the C-terminus of eukaryotic secreted Golgi casein kinase proteins. Fam20C is the Golgi casein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. Mutations in Fam20C cause Raine syndrome, an autosomal recessive osteosclerotic bone dysplasia.
Links
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Statistics
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PSSM-Id: 517381
Aligned: 36 rows
Threshold Bit Score: 291.053
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5YH3_A       243 FFVSPASNVCFFAKCpYMCKTEYAVC-GKPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYTLAGKEEWEV----NPLYCD 317 human
XP_009031446 276 L---AGNESCVRGFC-LYCKQEHSLC-PRDNIIEVSLTYWVP---RRLKLHTKPDLFMPYSTSRMEKWSVygfnNKTYCD 347
5_pfamImport   1 FREKD-GNTCYFGVC-LYCNERNMAC-GEGGLMEGSVTLWLPPKWSAFQ-KQRHPYQRTYVDGRKARWEN----DGRYCN 72 
XP_051714198 188 FLTAG-NNTCFYGKC-YYCRETEPAC-ADGDMMEGSVTLWLPDVWP-LQ-KHRHPWGRTYREGKLARWEY----DESYCD 258
XP_003439940 188 FLMQG-NNTCFYGKC-YYCRESEPAC-AEGEIMEGSLTLWLPDVWP-LQ-KHRHPWGRTYREGKLARWEY----DESYCE 258
EFX64528     234 FFKNNQSHSCFYGVC-RYCKPELSVCgGEGDLIEATVILWLNDVK--LK-SNRSPWQRTYKKNVRALWET----DDDFCI 305
1_pfamImport   1 IYQDG-NDTCLYGVC-HYCSPADPVC-GVGDILEGALISWLPRYLK-LV-KHRHPWQRTYKKNKLATWET----DDNYCE 71 
XP_002425587 206 FYDDG-NNTCFYGVC-LYCEPKSLVC-AKNDIMEGALIMWLPTKIK-FK-KYPSPWQRSYKSNLVARWEM----DENYCS 276
2_pfamImport   1 YINSTTKETCVYGKC-YYCKREDPVC-TKSERLEGAAIFHLP--SNIKLKQHLHPWRRTYIENKRARWED----DNDYCD 72 
EDO44241     171 FFKKG-GNTCFYGVC-YYCNKEEAAC-ANKTSMEGSMTIWLPQGWA-LR-KWRHPWQRTYNNRK-ASWEL----DNNHCK 240

5YH3_A       318 T-VKQ-IYPY--NNSQ-RLLNVIDMAIFDFLIGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSHDEISI-LSPLSQCC 391 human
XP_009031446 348 E-VRQtIEPY--EEVG-MYLDLFDFSVLDTLMYHFDTKHYTVDDGSSAHGLTVRLDHGRAFCAYDKHEKHIfLAPVYQCC 423
5_pfamImport  73 DvVKR-QAPY--DRGT-RLLDVADAAVFDYLIGNADRHHYEIFKNKSKDTMLIMMDNAKSFGNPHHHEPSI-LAPLKQCC 147
XP_051714198 259 A-VKK-TSPY--DSGP-RLLDIIDTAVFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSI-LAPLYQCC 332
XP_003439940 259 A-VKK-MPPY--DAGP-RLLDVIDTAIFDYLIGNADRHHYESFQDDGGASMLILLDNAKSFGNPALDERSI-LAPLYQCC 332
EFX64528     306 KlQKQ-NKVFrlEAGKrRLLDLIDASVFDFLISNGDRHHYEIIDGYS-EAAVLLLDNGKSFGRPDLDYVDI-LAPLYQCC 382
1_pfamImport  72 K-VKD-SKAYspQTSS-RLLDLVDTAIFDFLMDNGDRHHYELAQNNFHNPAVLLIDNGKSLGNPDIDHFDI-LAPLYQCC 147
XP_002425587 277 D-VKN-SKQ---NNQN-RLLDLTDAAIFDFLIDNGDRHHYEVPLGFN-HSSIFLFDNGKSFGNPYIDHIDI-LAPLYQCC 348
2_pfamImport  73 S-IKS-------NYNSeRILDFIDVSIFDFIIGNGDRHRYEVVEQF--NNTILLIDNGKSFGNPYKDHIDI-LAPLYQCC 141
EDO44241     241 K-VIQ-QSPY--DQGP-RLLDIIDTAVFDFLIGNADRHHYETFKKGDDEGMLVHLDNAKSFGNPDHDELSI-AAPLYQCC 314

5YH3_A       392 MIKKKTLLHLQLLAQADY-RLSDVMRESLLEDQ----LSPVLTEPHLLALDRRLQTILRTVEGC-IVAHGQQSVI 460 human
XP_009031446 424 TLRKSTYENLLKLRGG---KLSEMMKAALKSDP----LAPILKSVWYTVLDDRLRIILELIDKC-ISRNGSRQVL 490
5_pfamImport 148 ILRRSTWEKLQQLKNG---VLTQLLESILSADP----ITPVLHPPHFNAIDVRLPTIIETMEKC-IKDKSYDDVI 214
XP_051714198 333 IIRVSTWNRLNYLKNG---VLKSALHSAMAHDP----ISPVLSEPHLDAMDQRLLSVLATVKQC-TDQFGMDTVL 399
XP_003439940 333 MVRVSTWNRLNLLRSG---ALSSAMRQALAFDP----IHPVLAEPHLAALDRRLSGVIATIKQC-MEAQGPDNTL 399
EFX64528     383 VIRKSTFKRLEMLESG---PLGTLIEELTLKDSl---IGPLLTEEHVQAINRRLGKVMRTIQLC-AQVKSWDDVL 450
1_pfamImport 148 MIHKTTWDRLKLFSGG---TLSIALSKLVAHESimadVQPLITEVHLNAMDRRLLTIYAVVEYClKNKKYASNVI 219
XP_002425587 349 VIRKSTWERLKMFSGG---LLSSSLRNLLKYSD----ITPVLTNSHLFALDRRQLFIFAAVEMC-ITQYGESKVF 415
2_pfamImport 142 IIRLKTWERLKSIKGG---TFTNILQSMLDVHE----TLSLLTLPHYRALERRLKIIYATVVMC--QKKSDRSIL 207
EDO44241     315 QLRDSTYKRLKEIANNKVkPVGELLKEATSSDA----LAPVLTEPHFKAVTRRLSIVMDIVTRC-IERNGRRKVI 384
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