Conserved Protein Domain Family
SARAF

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pfam06682: SARAF (This model is not part of the current CDD release)
SOCE-associated regulatory factor of calcium homoeostasis
SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.
Statistics
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PSSM-Id: 517372
Aligned: 43 rows
Threshold Bit Score: 239.167
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007927079   7 AAVVLATTTTALAYSKKndAVKLSQVKTLTLRSDAKTSHRRVSAIPQLKCV-G--GNARGKYeVDVMRCTNSGSeyDSED 83 
XP_009013983   5 VFFVCFLATILACVSGHk-KVLLKDVQVVTLRNKEYTTGRRNKPIPQLHCLgGfsGCE-TVT-LDTVQCYNRGF--DGND 79 
XP_003772841  24 VLLLLPRPSPALAWDQSe-KILLRDIQALTLHRDRFTTARRTAPIPQLQCLgGsaGCPAHI--PEIVQCRNKGW--DGFD 98 
5_pfamImport   1 GLLLLLIAGPALGWNDPn-RILLRDIQALTLHYDRYTTSRRLNPIPQLRCIgGtaGCDTYT--PKVIQCQNKGW--DGYD 75 
Q08E24        18 LLLLLLVVGTAQCWDERd-RILLRDIKALTLYYDRYTTSRRLEPIPQLKCVgGtaGCDSYT--PKVIQCQNRGW--DGYD 92  domestic cattle
Q6AYN2        19 LLSFLLVAGPALCWKNPd-RILLRDVEALTLYSDRYTTSRRLDPIPQLKCVgGtaGCDAYT--PKVVQCQNKGW--DGYD 93  Norway rat
XP_035309907  19 LLSFLLVAGPALCWNDPd-RILLRDVKALTLHHDRYTTSRRLDPIPQLKCVgGtaGCDAYT--PKVIQCQNKGW--DGYD 93 
XP_003797715  18 LLLLLLIAGPALGRNDPd-RILLRDVKALTLHYDRYTTSRRLDPIPQLKCVgGtaGCDAYT--PKVIQCQNKGW--DGYD 92 
F7C1E2        14 PLLALLQIPGAWCWNHQe-RVLLRDIQAITLYADRYTNARRSAPVPQLKCIgGsaGCHTMV--PQVVQCHNRGW--DGFD 88  tropical clawed...
XP_015199412   7 IFVLFIYTGRTESWNDGg-SVLLRELQVITLYKGQYTNSRRTSPVPQLQCIgGtaGCGSFI--PEVVQCHNKGW--DGFD 81 
XP_007927079  84 VQWTCKASLPPEFKLGSTDVICEGYDSPNDPYILKGSCGVEYRL-MLTPEG----------ETKYGTQRAWRSKPDSYSg 152
XP_009013983  80 YNWECKADMPKHFKFGKMEVTCEGYDYPDDPYILAGSCGLRYELiDLSDKSglfspppdayEKKYSSPTSDYKNRHYTEk 159
XP_003772841  99 VQWECKAELDTSYRFGKTAVSCEGYDYPDDPYVLRGSCGLEFNL-ELTEQG----------RKKYKDAGSSNTNSHGNT- 166
5_pfamImport  76 VQWECKTDLDVAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYDL-DYTELG----------LKKLRESGKNN-------- 136
Q08E24        93 VQWECKTDLDVAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYQL-DYTELG----------LKKLRESGKEH-------- 153 domestic cattle
Q6AYN2        94 VQWECKTDLDIAYKFGKTVVSCEGYDSSEDQYILRGSCGLEYNL-DYTELG----------LSKLKESGKHQ-------- 154 Norway rat
XP_035309907  94 VQWECKTDLDIAYQFGKTVVSCEGYESSEDQYVLRGSCGLEYHL-DYTELG----------LKKMKESAKHQ-------- 154
XP_003797715  93 VQWECKTDLDVAYKFGKTVVSCEGYESSEDQYVLRGSCGLEYNL-DYTELG----------LKKFKESGKHH-------- 153
F7C1E2        89 VQWECKVDMDNSYRFGKVEVSCEGFDYPEDPYVLRGSCGLEYTL-ELTEEG----------RKRSQDGYRSGG------- 150 tropical clawed...
XP_015199412  82 VQWECKTDMDYSYRFGKIEVSCEGYNYPDDPYVLKGSCGLEYTL-ELTEEG----------KQKGRNSRS---------- 140
XP_007927079 153 S----------D----VNDTIPTLL-F-WLFFLFVVGVIIYSVWNggr----nnHGNAGRRTGRGGWGGGGGDD----GS 208
XP_009013983 160 tk------------akDSSSETSPLfIfCIFVGIIVVVLWYSKSRqqaptsqasDPPAPPPYGFRASPPPYDDH----VG 223
XP_003772841 167 YgsnyfpgyveKmdspVPS-STRGL-L-AVVILLVLALGVYKLFLkaqn--edlPPPY-------TEHPQDhqrff---- 230
5_pfamImport 137 Gfnpf---sdyYk--sNSS-GISGL-I-TIVVLLAIAFGVYKLFLggg---qdsPPPY-------SESPPYspgfq---- 194
Q08E24       154 Gfnsfs-nyysKlyspESS-SLGGV-V-TIVVLLAIAFGVYKFFLsdg---hesPPPY-------SEDPPYshryq---- 215 domestic cattle
Q6AYN2       155 Sfsd----yyhKlssvDSC----GL-V-TVAVLFVLAFVVYKLFLsdg---qgsPPPY-------SEHPPYsqhsq---- 210 Norway rat
XP_035309907 155 Gfsd----yyhKlyssDSC-GISGL-V-TIGVLLAVAYVVYKLFLsdg---qasLPPY-------SEYPPYsqryq---- 213
XP_003797715 154 Sfaafs-dyynKwysaDAC-STGGL-I-TIVVLLTIAFAVYKLFLsdg---qcsPPPY-------SEYPPFshhyq---- 215
F7C1E2       151 FgsgyfqsnsnSwdtkTNGSSA----I-VLIVIVIIAYGVYKLFLsg----------------psVQEHPRPDE----YG 205 tropical clawed...
XP_015199412 141 FgsgffqdsssNvnyqGSGGDVSGL-M-VVAVLLLLAYGVYKMFLcgp---------------hgQGHQRFPDAdfsnan 203
XP_007927079 209 n---------DDPPPPYTP-------------------RA----QPKPKTYsntrssSSSSsNNQQWRPGFWSGTAAGAA 256
XP_009013983 224 s---------QQPPPPGFNtgfspppf---qsppsygfKTnagnQQQQQQQ------QQQPrQQSSRIGGFWTGASLGGL 285
XP_003772841 231 -----qasppPPPPPPGFKsyftasg------tpgwgfGNsftgPQA---------------FGQSG-PGFWTGLGTGGL 283
5_pfamImport 195 -----gftnsAGPPPPGFKpgftgmfg---tpgatygfGSaftgQQG---------------NANSG-PGFWTGLGTGGI 250
Q08E24       216 -----rfsssAGPPPAGFKseftgph------gatagfGSaftgQQG---------------HEHSG-PGFWTGLGTGGI 268 domestic cattle
Q6AYN2       211 -----rfagtAGAPPPGFKsdftgpqst--sygassgfGSafggQSY----------------ASSG-PGFWSGLGAGGL 266 Norway rat
XP_035309907 214 -----rssyaAGAPQPGFKseftgp--------qntgfGSaftgQGC----------------DNSG-PGFWTGLGAGGL 263
XP_003797715 216 -----rftnsAGPPPAGFKseftgpqnt--grgatsgfGSaftgQQG---------------HENSG-PGFWTGLGTGGI 272
F7C1E2       206 ydfqs-qtraSAPPPPGFKsdftdphlc-kifgasksfSSgygtSHS-----------------NQG-PGFWTGLGTGGV 265 tropical clawed...
XP_015199412 204 tdghftdgntMGPPPPGFKsyytgespgyesardsygfKNtftrPHQ---------------KPASG-PGFWTGMGTGGV 267
XP_007927079 257 AGYAasqfanrnnrtryedpqpgpsswfgggrrqpdyretePSGWfgs----------snrSPSYGGGSSWGGGSSTPS- 325
XP_009013983 286 AGYLfgsrrnsnnyggrdyyd---sgssyfggsryrnvgsrGDGWf--------------gSGSSGWGSAAGSTTTTTTs 348
XP_003772841 284 LGYLfgnnr----------------------------atplSNNWthpaypppyfntwnnpV--PPSAPVNSRSSGSSSg 333
5_pfamImport 251 LGYLfgsnra--------------------------tttpfSDSWyrpsypsy-fgtgnsrASSPHCGDSGNYSACSss- 302
Q08E24       269 LGYLfgsnr---------------------------aatpfSDSWypsyppsy-tstwnsrAYSPLRGGPGSSSACSgs- 319 domestic cattle
Q6AYN2       267 LGYLfgsnr---------------------------aatpfSGSWyhpsypssyagawnshAYSPLGGGAGRYSASSnt- 318 Norway rat
XP_035309907 264 LGYLfgsnr---------------------------aatpfSDSWyypsyppsypgtwnsrAYSPLGGGAGSYSASSSLn 316
XP_003797715 273 LGYLfgsnr---------------------------aatpfSDSWyypacpppysgtwngrASSPLRGSSGGYSACAna- 324
F7C1E2       266 LGYLfgnrraq------------------------pyqapyFNTWtgp-------------------snsDSMHQNYRPp 302 tropical clawed...
XP_015199412 268 LGYLfgs----------------------------------------------------qrSQPRYFTRNTGNSNIGPTp 295
XP_007927079 326 --SSRHESTGFGGTRRR 340
XP_009013983 349 saPNTETRSGFAETKRR 365
XP_003772841 334 sdTGTRTTSGFAATKRR 350
5_pfamImport 303 -qTKTRTASGYGGTKRR 318
Q08E24       320 -ePRTRTASGYGGTRRR 335 domestic cattle
Q6AYN2       319 -eSRTRTTSGYGGTRRR 334 Norway rat
XP_035309907 317 adSRTRTASGYGGTRRR 333
XP_003797715 325 -eTKTRTASGYGGTRRR 340
F7C1E2       303 qsSGVRTASGFGGTKRR 319 tropical clawed frog
XP_015199412 296 vnSGTRTVSGFGGTKRR 312
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