Conserved Protein Domain Family
ITI_HC_C

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pfam06668: ITI_HC_C (This model is not part of the current CDD release)
Inter-alpha-trypsin inhibitor heavy chain C-terminus
This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.
Statistics
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PSSM-Id: 517370
Aligned: 50 rows
Threshold Bit Score: 161.204
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_056660882   673 DTGITVNGEIIGEKEaSSETKNRKTYFGKLGIID----PRIDLKIEVTTQKITLw-SGGRGNSFTWMDSVIITENSLSVT 747 
12_pfamImport    1 TQNLTVNGDIVAVAApPGSMKPNRTYISNLYIHI----PQQKFKIIVRPYNVTFipVGAQPFTVPVTTPIRFNGKGIRFQ 76  
8_pfamImport     1 ITGLSVNGHLMGAPLrPGHEERPRTYFDAITIVVgellPLPGYVINITRKGITL--HGEHILVLPFTQRATIHKPQLVIS 78  
XP_007667881  1126 TAGLRVNGHLVGAPPkVGHEDRSRTYFDMISVVVq--yPRVSYALNITRDSISL--KGEDSLVIPWSRPAFIQKPRLALK 1201
EGW02319       786 KAGLHVSGKLLGAPPrPGHEDQTRTYFQIITITSd---KPWAYTVTIGLSSISV--QGEGTLNLPWDQPALVKKPQLELH 860 
XP_008108460   734 NSGVTVNGQLIGAPApRNGHKKHRTYFRSITILSs---KPERAYLEVTPTKLIL--DDGKRLVLSCDRTAVVASKNLEVS 808 
24_pfamImport    1 KSGVTVNGKLIGAPApLNSHKKQRTYFSTITIMVd---KPRRSYIEITPRKVIL--DSKDRMILPCDKTIMVDSDGLAVS 75  
XP_005993945   740 NSGVTVNGQLIGAPApPNGHKKQRTYFSSITVVVn---RPHRAYIQITPHKIVL--DSVDRLVLPCDKTASVESHGLAIS 814  coelacanth
XP_064414995  1080 QSGVEVTGHLLGAPPkTAHENFLRNYFDLITITVr--rPAGNYLINVTMRNVTV--QGEGLHTLSCYRTASLHLPGLTLS 1155 coelacanth
XP_009859948  1375 VNGISVNGKLAQTPV-HISETDSPTFISDLGISL----ANQGINIQIDSFTLVIriRGGRPQQFSLKKMFRIKRRGVWFE 1449 vase tunicate
XP_056660882   748 INRKK----NMVISIG---DGVTFVIVLHPMWKK----QDFLGLYT-VDSHRMSTQTHGLLG------------------ 797 
12_pfamImport   77 VHGIT----HTRARIDviiDGLNFQVVLH-RNNRhlysTDHLDFSVrSSGSKLGRGVDGVIG------------------ 133 
8_pfamImport    79 MWPEA----NVTVQIG---HELEFLVLLHRYSHPtalqLDHLGFYM-VNGKGLSPSACGLLG------------------ 132 
XP_007667881  1202 VSPSA----NVTLWIG---TDIEFLILLHRYSHPtylqLTHLGFYI-VNGKGLSSSAQGLLG------------------ 1255
EGW02319       861 VASAA----HLTLQLG---PHLNFLILRHQYRHPstlqLPHLGFYV-ASDSGLSPSARGLMG------------------ 914 
XP_008108460   809 IFARS----NVTVVLR---GTIGFVILIHHYKNPapyqKDHLGFYV-SSSKGLSANSHGLIG------------------ 862 
24_pfamImport   76 IVEKS----NITVTIQ---DQISFVILVHQYKNPapyqKDHLGFYI-SNSKGLSSDSHGLLG------------------ 129 
XP_005993945   815 VTARS----SITLTIQ---GSISFVILVHQYKNPapyqKDHLGFYI-SNSKGLSSNSHGLLGqflyrevqlnelpgnnta 886  coelacanth
XP_064414995  1156 VSHRA----NVSIQIG---NSLDFLVLLHHFHHPtylqLDHVGFYV-VNGKGFSPSAHGILD------------------ 1209 coelacanth
XP_009859948  1450 NQPISytryELMIKLP---QDIQFQIVSH-VHAPnaniINHLDFSI-VRSSGLSNATSGVLG------------------ 1506 vase tunicate
XP_056660882   798 ---QFFHPfDFEVFDVRPG--------------SDPKKPDATMIVKNNKLIVTRGSQKDYRKDsshgSKVFCWFVHD 857 
12_pfamImport  134 ---QFLNShVIVLN-------------------GDAEEKEAFILIDEQLGQVTRTKKKLPTDR----GMIECWFARN 184 
8_pfamImport   133 ---QFQNS-GIQLSSGAVD-----------------GEPATWLWRGASKIPVTEVTKILKDSPqr-aHEAPCWLVKR 187 
XP_007667881  1256 ---QFQHA-DIQVNREQGT-----------------RAQTGVLRSEAATLPVVWVEKLLKDSAlq-pHKTHCWLVKR 1310
EGW02319       915 ---QFQHT-DIRLVTGPTG--------------------SYLQKHRGPGVPVVLGKKLLKESPrlhpRWTSCWLVKR 967 
XP_008108460   863 ---QFLHQ-DVKLTQDPLGpspfmgs-wnqtkgVDVNSGSTLLKLKGRLVPVVWKQRKIYNGE----QEVDCWFAKN 930 
24_pfamImport  130 ---QFLYQ-DVRLTEMPLNgtafkslqnetqaeSEPLASSTALKIKGRLIPAVKKQRKIYSGK----HKVDCWFVKN 198 
XP_005993945   887 vsdSFQNQ-TAQLTTSPAQ------------------SITTMLKVKDRLVPVVRKQRKIYNGR----QKVDCWFAKN 940  coelacanth
XP_064414995  1210 ---QFLYA-DINVTRTAGDvtqe-------tcpDCRRPVTGVLRISGWNIPVTLVTKNIKDSYlk-pHEGPCWQVGK 1274 coelacanth
XP_009859948  1507 ---QFPHNsEIAPATID----------------FIPNTQHALLWFRHSMVKVT----NHIMYDsltkRTIECWWVKN 1560 vase tunicate
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