pfam06664: WLS-like_TM (This model is not part of the current CDD release)
Wntless-like, transmembrane domain
This entry represents the seven transmembrane domain of wntless (WLS) from Drosophila and its homologues, also known as MIG-14 in C.elegans which regulates endocytosis and secretion of the wnt ligand egl-20. Newly synthesised EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion. WLS is a membrane trafficking and secretion chaperone for lipidated Wnt signaling proteins. It regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This entry also includes TMEM181, a cell surface protein associated with Escherichia coli CDT toxicity. Members of this entry are homologous to GPR180 and TMEM145, and together with TMEM87A/B, GPR107 and GPR108, they have been described as GOLD domain seven-transmembrane helix (GOST) proteins given their domain architecture similarities. They all consist of a GOLD domain atop of a seven-transmembrane helix domain.
Jiyao W et al.(2023). "The conserved domain database in 2023.",