Conserved Protein Domain Family
C5-epim_C

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pfam06662: C5-epim_C 
D-glucuronyl C5-epimerase C-terminus
This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyze the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans.
Statistics
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PSSM-Id: 399566
View PSSM: pfam06662
Aligned: 15 rows
Threshold Bit Score: 184.857
Threshold Setting Gi: 81418004
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK33137     249 MD-SIGAIRYDFNYKHYLDDNefq-pgwISAMAQGQALSVFSRAYHLTGNKKYISAGNLALNFLTTKTSQGGPMDNLSFl 326 Clostridium klu...
Q8RBZ5       108 QD-ELGGWDVFERIGSKKFYK-------YSAMTQGEGASLLIRAFQESGDEEFVDRAKKAIDLMLLPVEKGGTARYVND- 178 Caldanaerobacte...
O26430       215 RGmKYAVFPMYFDYCGsga-------gwLDSFAQGNLAGHYARAYRLTGDPEYLKISDALINSFRAPA---GLVKSTKY- 283 Methanothermoba...
Q58528       127 KNiTFIVWRYNFEFPLYNlsk-----gwRGALCQAGCLKTLYLAYEATGDERYLNYANLAINAFKVPVEKGGLLKIRIYk 201 Methanocaldococ...
WP_012109316 101 DN---GDWGGVYCYNELYGSGynlpnpwLSAMSQGFILSVFYEAYILTDKIDYLHMAEKVLNSFDIYSENGGFKSDWGT- 176 Campylobacter h...
O18756       416 QD-EKGGWPIMVTRKLGEGFKsle-pgwYSAMAQGQAISTLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNk 493 cattle
Q29RD8       384 QD-EHGGWPIKVTRKLGEGFKsle-pgwYSAMAQGQAMSTLVRAYLVTHNPSYLGAAIRATSPFKRTPEQHGVKATFMNk 461 zebrafish
Q1IKT3       115 QDaTTGIWYINYSFTV-AGMGvtlsppwGGAMAQGQAISVLSRAYQVTHDEKYLTAASKALAPLAKKVSEGGLTDDFFGd 193 Candidatus Kori...
EDK32457     213 QS-PSGAMRLDFSFKHYINNDiyk-pgwVSSLAQGQAISAFVRAYQVTGDNKYLDAADKAYMFMCIPVNEGGTKDTSEDl 290 Clostridium klu...
EDK33052     174 KD---GSFRYEFKYHHYEPldv----gwTSSMSQGQALSLFARAYNLTKDVKYLNSGGRVLKYLLTPISKGGVMDNLETl 246 Clostridium klu...
EDK33137     327 gnqmadYIFFQLYITDPPSYTLNGHMFTLIGLYDWSni--snNKDYSDKASAYFKKGLLTLKYILPYYDIGGFVCYDlgy 404 Clostridium klu...
Q8RBZ5       179 ------KLFLEEVVESKPVLILNGWIFAVFGLYDIF------KATSDGRYKEALQRTLDTLKDELYKYDTGYWSYYD--- 243 Caldanaerobacte...
O26430       284 ------GNFYLHYNFMRQHYILNAHLICTLGLHRAY------TYTGNTRALMLFREGVSTFRAMHRRFDSGRWTYYAvdg 351 Methanothermoba...
Q58528       202 n---ksYYWFPEYASENPPYVLNGFITATLWIGDFG------NKTGNADALYLYKEGLKSIKTFLPMYDAGDWSYYD--- 269 Methanocaldococ...
WP_012109316 177 ------GIWYDEYPTSPKKHVLNGFIFSLAGLYDYY------TYTNSDKAKKLFLQGIDSLKEHLASFDAGFNSYYSwse 244 Campylobacter h...
O18756       494 ------HDWYEEYPTTPSSFVLNGFMYSLIGLYDLKet---aGEKLGKEARSLYERGMESLKAMLPLYDTGSGTIYDlrh 564 cattle
Q29RD8       462 ------FDWYEEYPTTPSSFVLNGFIYSLIGLYDVAet---aGNKLGREAGILFSQGLESLKAMLPLFDTGSGTVYDlrh 532 zebrafish
Q1IKT3       194 p----nLPHYEEYPTVPASYTLNGFMFTLVGLYDLS--------AFDATALSMYNAGLKTLDAELPYHEMGGISAYHlgh 261 Candidatus Kori...
EDK32457     291 dg--tdNVFFQEYITTPKSYTLNGFIFTIIGIYDLSqt---kDSIYKGDAHKMFVNCNDTLLKVIHKYDLGCMTAYDaay 365 Clostridium klu...
EDK33052     247 ddrlkdKVFFQQYVNSTSTYTLNGFIFTLIGLYDWSnvncpgNIYYSNIAREYWDKGLNSLKLIIPYYDIGEFTAYDlhh 326 Clostridium klu...
EDK33137     405 ltrpgTPPTVN-FDYYGIHLTLLDALNIIT-GENDFKYYRNLWTS 447 Clostridium kluyveri DSM 555
Q8RBZ5       244 -----QCGNLAsPFYHKLHIALLEVLYELF-NTIEFKTVKEKWES 282 Caldanaerobacter subterraneus subsp. tengcongensis
O26430       352 --gsyRPAWLAsEGYHRLHVQLANSLWKAT-GDSYYRSIALRWNS 393 Methanothermobacter thermautotrophicus str. Delta H
Q58528       270 -----ALGHRCnKHYEHLHRLQMLWLYNKT-GDEIYLKYYKKWRE 308 Methanocaldococcus jannaschii DSM 2661
WP_012109316 245 npyihGIASMVgNKYHDLHIDQLLWIYYVT-NDMFFKNYAHKFLK 288 Campylobacter hominis
O18756       565 f-mlgIAPNLArWDYHTTHINQLQLLSTID-ESPIFKEFVKRWKS 607 cattle
Q29RD8       533 f-tlgVAPNLArWDYHTTHINQLQLLASID-GAPIFRDYVKRWKT 575 zebrafish
Q1IKT3       262 itnapRGPHVA-WSYHLVHLQLLGALKYLNpTDKVVSFYYGQWCS 305 Candidatus Koribacter versatilis Ellin345
EDK32457     366 itkkdQYPNMN-IQYHASHIELVDAMYSIT-NNPIYKYYNLMWKS 408 Clostridium kluyveri DSM 555
EDK33052     327 vvkksKPSSSD--FYHSVHIEQMNVLYNIT-KDHYFKNIRDMWIS 368 Clostridium kluyveri DSM 555
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