Conserved Protein Domain Family
MipA
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pfam06629: MipA 
MltA-interacting protein MipA
This family consists of several bacterial MltA-interacting protein (MipA) like sequences. As well as interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex.
Links
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Statistics
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PSSM-Id: 488472
Aligned: 134 rows
Threshold Bit Score: 101.695
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
tigr:CJA_0035                    42 LGI--------------GLGVRTNpL---EDgd-dIPLVL-LPMVS----YTGER--FFIDNL----D------F-G-YT 84 
Q2SEW6                            2 LGV--------------GAAAWKSeYegvSGs--dELAV--YPAIS----YKGDR--FSISGT----E------A-D-YR 45  Hahella chejuensis KCTC 2396...
Q87JD5                           40 VGVaqgsdlfkdqkhntAPILNGG-YhgeDF----NADLGgINYRFlgetNDLINmsAYVVGSgiirDgdvaksLkG--- 111 Vibrio parahaemolyticus...
Q12RS5                           41 AGVatgskffkdqddqtGVYFNGG-YhgeDF----NADLGgINYRFfgnnDSAINfsAYMVANpg-fDtdsediLkG--- 111 Shewanella denitrificans OS217...
WP_013662259                     47 LGA--------------AVVSSESvIvgeDD----DDLKL-YPYAK-------------LEY--------------GnFS 80  Marinomonas mediterranea...
WP_013662302                     32 VGV--------------GLALLQS-HvkgEG----NEAEL-FPMVE-------------LSY--------------AdFS 64  Marinomonas mediterranea...
WP_014957661                    104 IGL--------------AVFAEKEiY---KGa--dDEIQP-AVFLR----YENGP--FEIMTT----Dai---dV-S-YE 148 Desulfobacula toluolica...
WP_007640902                     34 LGL--------------GAVISDQgY---IGv--sNVVTP-VPVIY----YQTEN--FQLLGP----N------F-S-YK 75  Paraglaciecola psychrophila...
WP_025422535                     45 LGL--------------GGSVKRSpY---RGv--gTDLGV-LPLLN----YENRY--LRFFGT----T------L-D-AK 86  Sodalis praecaptivus...
dbos:1099484000104_PB2503_09289  40 VGL--------------GIGAVMEaY---RDldedTRILP-TPVLR----LDGRR--FSVSGT----S------A-S-YS 83 

tigr:CJA_0035                    85 LWESDtqq-----lnlLLTPSYDQVfferwdpvnfvlespglgtalngggknssdpkepyplidpgvsgSGDFEGPESLQ 159
Q2SEW6                           46 VLGDGd-----------SGLNAYVSlgmgdg--------------------------------gydasdSVVFAGMDDRD 82  Hahella chejuensis KCTC 2396...
Q87JD5                          112 ---------------------------------------------------------------------------TQKRR 116 Vibrio parahaemolyticus...
Q12RS5                          112 ---------------------------------------------------------------------------MKERD 116 Shewanella denitrificans OS217...
WP_013662259                     81 ISKDGiglafelnetdSLSFLLSSRdsaf-------------------------------------dssNAALRAIDTPD 123 Marinomonas mediterranea...
WP_013662302                     65 LSPDGlgytyeltplsALFFSLSTRdasf-------------------------------------dssNTKLSNLNKRD 107 Marinomonas mediterranea...
WP_014957661                    149 LFDTKl-----------FSVALRGSvlfdeg---------------------------------ydpddSTYLKGMEELD 184 Desulfobacula toluolica...
WP_007640902                     76 LAGMS-----------DLTFSITGQlrfdg----------------------------------feeddSDVFIGMDDRS 110 Paraglaciecola psychrophila...
WP_025422535                     87 LPAAG-----------PVDFSLRAQyrlgdg---------------------------------ykasdADYLDGMAERK 122 Sodalis praecaptivus...
dbos:1099484000104_PB2503_09289  84 LLKGEkwe-----aaaTLDYR-FQGyda---------------------------------------edSPIFQGMDDRD 118

tigr:CJA_0035                   160 RKLPkrhmsglAGLEYHFR-LGGYG-LHLHWLKDVtDIHQG-EERRLALSRAWQA----------GNHDLALSAGAVWQD 226
Q2SEW6                           83 ASID-------LGVGVEYA-FDQGS-LNAAIAHDVsGAYKG-LVGSASFSSSQKLs---------DTLYLTPSAGFYYRS 143 Hahella chejuensis KCTC 2396...
Q87JD5                          117 LAVD-------LGLNTDFTldehnvi-stylqhDIsGAYKG-----------YLAgatyfhimnfGSVDFVPFANLTYQS 177 Vibrio parahaemolyticus...
Q12RS5                          117 FSGD-------LGLNADFHlgqgtl--sakfqhDItGAYDG-----------YQAdityyhpmdlGFASLVPYAGAHYFS 176 Shewanella denitrificans OS217...
WP_013662259                    124 DAID-------LGLTWSTKtKFAEYgVSGIT--DVsDTHNG---------YELSFsvak--pmraLGGLLKPSVELSLQS 183 Marinomonas mediterranea...
WP_013662302                    108 DAGE-------FGIAWVQTsPSMELtTYLIS--DIsDTHKG---------YEIGVdlgl--pttfAGGYLTPSIGVSYLS 167 Marinomonas mediterranea...
WP_014957661                    185 TLFY-------TGLGFEKQ-FAGWE-ISLEVLQDVsGEHDG-QEIELALEYQWSA----------AGFEFRPNVSLIWMS 244 Desulfobacula toluolica...
WP_007640902                    111 GSFD-------LGLLVDYE-TNLGD-FSAEFITDAtNEHKG-NEFSLTYSKSYDFe---------T-YSIKPYLTLTRQS 170 Paraglaciecola psychrophila...
WP_025422535                    123 GGLA-------LGLATTWH-SPFAD-VSLEWLR-AtNDSKG-NRVTVAVERTFDYd---------SDLHFTPYIEVQRAD 182 Sodalis praecaptivus...
dbos:1099484000104_PB2503_09289 119 STLE-------GGGWYSYK-IGPAI-LTAYALTDLfDRHGGyELRGVAAYKVVDN----------RATKVTPYLGLSFQS 179

tigr:CJA_0035                   227 ATLTNYYYGVPQGDAy----------wASYEAGNALSTQ-VRFDWNY--RLSKHWDLRALLSYRRLPEEITASPLVRSDK 293
Q2SEW6                          144 SDYVDYYYGVRDSEAts--------drSAYEGDDTLTPF-VGYELFT--VLSEHWRISHSAEVRWLGDEITDSPLVDRST 212 Hahella chejuensis KCTC 2396...
Q87JD5                          178 EDYVDYYFGIKDREAtan--------rkAYKGDA---TVsYGLGYKLvmPINDNWQINQTTQYTRLGSGISDSSVVDSAN 246 Vibrio parahaemolyticus...
Q12RS5                          177 NEFVNYYTGVASFEAtsk--------rpAYQSNG---ALaFKVGYVLdiPITENLSLTQATAYTHLGSNMADSPIIDAKN 245 Shewanella denitrificans OS217...
WP_013662259                    184 EDIVDYYYGVSASEAtse--------laAYKGKS---ALlTSLGVQYlyQLTDSWVTLTSVSYTHLGAGITDSPIVDKDS 252 Marinomonas mediterranea...
WP_013662302                    168 EDLVNYYYGVSQSEVtgs--------igSYESDGSFGAN---VGLEYvyKIYSGWHSYTAVSMEYLGSGISDSSIVDRDT 236 Marinomonas mediterranea...
WP_014957661                    245 GRTVDYFYGVSSKEAra--------drKAYSPGSSYEIG-AELMVER--LIFGNFSAVGFIGISTFGGDITDSPIVDEDY 313 Desulfobacula toluolica...
WP_007640902                    171 EDIIDYYYGVHANEVtq--------nrALYLGEATTNAE-IGVQANW--RVGQHHNFITYASHTVYGSEIKDSPLIDASG 239 Paraglaciecola psychrophila...
WP_025422535                    183 RKDVDYYFGVKDSESrp--------drPAYDGKASTNVN-GGVRMDY--ALTRHQHLLLDVGVRYWGSGVTDSPLVEHDA 251 Sodalis praecaptivus...
dbos:1099484000104_PB2503_09289 180 EDLANYYYGVEADEAatlvidgesvtrAQYVPGETLTPF-VGITARQ--ALSRKWAiaatgRYEFLPDEVVDSPLTDADS 256

tigr:CJA_0035                   294 VVTAFIGGVYHF 305
Q2SEW6                          213 VWSAALNFLYLF 224 Hahella chejuensis KCTC 2396
Q87JD5                          247 QWVVGASVSYNF 258 Vibrio parahaemolyticus
Q12RS5                          246 QWLTTFGVNYSF 257 Shewanella denitrificans OS217
WP_013662259                    253 AWSGVFGIAYKF 264 Marinomonas mediterranea
WP_013662302                    237 VWSGVIGIVYEF 248 Marinomonas mediterranea
WP_014957661                    314 STQVGFGIMYAF 325 Desulfobacula toluolica
WP_007640902                    240 SVNVILAYMYVF 251 Paraglaciecola psychrophila
WP_025422535                    252 SPSLRLGYIYRF 263 Sodalis praecaptivus
dbos:1099484000104_PB2503_09289 257 RAFFALALARLf 268
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