4Y7I


Conserved Protein Domain Family
Myotub-related

?
pfam06602: Myotub-related 
Click on image for an interactive view with Cn3D
Myotubularin-like phosphatase domain
This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.
Statistics
?
PSSM-Id: 399535
View PSSM: pfam06602
Aligned: 206 rows
Threshold Bit Score: 250.855
Threshold Setting Gi: 190586525
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4Y7I_B                 1 Mr---ESGWKLIDPIS--------DFGRMGIpn----------rnWTITDANRNYE-ICSTYPPEIVVPKSVTLGTVVGS 58   human
Q7KSP6              1121 qnnamprllttkdvermrersyvqDWKRLGFdaes-------qrgFRISNANTSYA-TCRSYPAIIVAPVQCSDAAIMHL 1192 fruit fly
WGS:AAQB:GK14310-PA 1135 qnetlprllsskdiermrersyvqDWKRLGFdaes-------qrgFRISNANANYA-LCRSYPAIIVAPVQCSDATMTHL 1206 Drosop...
EFA77446             497 vfafasqentIDASENfcqrlipgEFDRQGVsw----------deWCVNTTNSQLKlNTMSYPPASVIPKSVSQNIVVAS 566  Hetero...
XP_003228769         118 SmrlaGGGRQPHALEK--------YYQQVasr----------tgaWRLSVVNEDFQ-ACPSYPALVVVPSSVDDAALRKS 178  green ...
XP_005317803         117 kglrlGDAWHFHPPEC--------YYKRVAret----------naWRLSEVNQDFS-LCPSYPRAVIVPRAVDDDALARS 177  thirte...
XP_006003301         117 Dma-lKEGWDLYSPEQ--------EFTCMacp----------tdfWRLSYVNKDFS-VCSTYPSAVIVPQNIDDGSLKKS 176  coelac...
Q965W9               129 Ti--lDDGWSAFDLEQ--------EFARLMLst----------daFRISSVNENFA-ICPTYPEKLIVPKGIGDDYLKIS 187  Caenor...
XP_017946599         141 Gys-lGHGWPRDTMEN--------FYHKMrae----------tddWRLSEVNLDFK-ICPSYPAKVIVPRICSDETLQKA 200  tropic...
XP_014348815        1060 tlsttmkssdkmtmshvveraccrDYQRLGLgtlsnslsrsknepFRISTVNRMYT-VCRSYPSLLIVPQTIQDSTIQRI 1138 coelac...
4Y7I_B                59 SKFRSKERVPVLSYLYKENNAAICRCSQP----LSGF------------------------------------------- 91   human
Q7KSP6              1193 GRCFKGQRIPLPTWRHA-NGALLIRGGQPnsksVIGMlknttgs---------------------------------ttn 1238 fruit fly
WGS:AAQB:GK14310-PA 1207 GRYFKGQRIPLPTWRHQ-NGALLIRGAQPnsksVIGMlknttgantmth------------------------hhhhhlh 1261 Drosop...
EFA77446             567 SLFRSL-RFPVLVWHHPTNRACITRAASPsndaSNSLspptsaplsprsgsnnninnnnnsnssnnsnsnsshssnnnts 645  Hetero...
XP_003228769         179 ARFRQGGRFPVLSYYHKKNGTVMLRSSQP----LVGPh------------------------------------------ 212  green ...
XP_005317803         178 ARFRQGGRFPVLCYHHAPSGTVLLRSSQP----LTGPq------------------------------------------ 211  thirte...
XP_006003301         177 ARFRQGGRFPILSYYHKKNGMVILRSSQP----LVGAn------------------------------------------ 210  coelac...
Q965W9               188 ATFREGGRFPVLSYFHKETKSPLVRCSQP----LIGPt------------------------------------------ 221  Caenor...
XP_017946599         201 AAFRQAGRFPVLSYYHSANQTALLRSAQP----LFGTa------------------------------------------ 234  tropic...
XP_014348815        1139 SRCNRQNRFPVVCWRNSRTKAVLLRSAGHsskgVSGLfksqnps---------------------------------atg 1185 coelac...
4Y7I_B                92 ----YTR----------------------------------------CVDDELLLEA-ISQTn----------------- 109  human
Q7KSP6              1239 ahhdVTH----------------------------------------YPEQDKYFLA-LINTmpkltplalnqysgmnls 1277 fruit fly
WGS:AAQB:GK14310-PA 1262 hphdVSH----------------------------------------YHEQDKYFMA-LINTmpkmalnqysglnlsmss 1300 Drosop...
EFA77446             646 ssnsNSNsnsgmssstsstnlnifnslghplspshslssnqlsnpnpCNEDIDFIRAiIDNG------------------ 707  Hetero...
XP_003228769         213 ----RKR----------------------------------------CPEDEGLLAAaLDGR------------------ 230  green ...
XP_005317803         212 ----KRR----------------------------------------CAEDEDLLRA-VLAg------------------ 228  thirte...
XP_006003301         211 ----GRR----------------------------------------CKEDEVLLSSaLNQA------------------ 228  coelac...
Q965W9               222 ----NRR----------------------------------------CREDETILNS-MITV------------------ 238  Caenor...
XP_017946599         235 ----PHH----------------------------------------CKHDEALLNAaLMEQ------------------ 252  tropic...
XP_014348815        1186 qsqtDSS----------------------------------------SLEQEKYLQA-IINSmphysdasgrntlsgfts 1224 coelac...
4Y7I_B               110 --------------------------------------------------------------------PgS--QFMYVVD 119  human
Q7KSP6              1278 msslmghsssddrqp---------------------ltpelsrkhknnldisdgnkssqggkggtmkgNpKnsLAHPFRK 1336 fruit fly
WGS:AAQB:GK14310-PA 1301 llghgedhh--------------------------------ahhhhhhaqqpmtpevtrkhegksstmKgTsaAPLGFRK 1348 Drosop...
EFA77446             708 --------------------------------------------------------------------K-S--SLLTVYD 716  Hetero...
XP_003228769         231 -------------------------------------------------------------------------SRGFVLD 237  green ...
XP_005317803         229 -------------------------------------------------------------------aHp--gARGFIVD 239  thirte...
XP_006003301         229 -------------------------------------------------------------------------EQGYIID 235  coelac...
Q965W9               239 -------------------------------------------------------------------------NRGYIID 245  Caenor...
XP_017946599         253 -------------------------------------------------------------------------SSGFIID 259  tropic...
XP_014348815        1225 ahmnssapsprsrvisvsipkssvkvrgtpkgkwgsmrgssstrmssyipssevglrlaardttspqpNgGpsEAHFLRQ 1304 coelac...
4Y7I_B               120 TRPKLNAMANRAAGK-GYENed-nYANIRFRFMGIENIHVMRSSLQKLLEVCel----ktPTMSEFLSGLESSGWLRHIK 193  human
Q7KSP6              1337 MR--LYALGEKSQAK-SNMNvdfcAD---FIPVDYPDIRQSRPAFKKLIRACmpshntneADGQSFAKMVEQSDWLQQIS 1410 fruit fly
WGS:AAQB:GK14310-PA 1349 MR--LYALGEKSQAK-SNLNgdfcAD---FIPVDYPDIRQSRSAFKKLIRACmpshiandADGQSFAKMVEQSDWLQQIS 1422 Drosop...
EFA77446             717 ----IGTVASHSSTMiG----------CKFEFLNLPPITSVKESFSRLLQlh------ngHPDKKWPDVIR-FHWLNPLK 775  Hetero...
XP_003228769         238 TRSAQAAKQAKMMGG-GTEHrs-aYAGWKRMHRALDRGRPLQESFVKVVETCnd----psLTMDRWLSKLEASKWLTHVK 311  green ...
XP_005317803         240 TRSAQAAKQARMTGG-GTEAka-aYPgWKRLHRPLERGRALQESFVRLVEACgd----peQSMDRWLSRLEGCRWLAHVK 313  thirte...
XP_006003301         236 TRSTQVAQQAKVMGG-GFESks-nYPKWKRFHRSLERGRVLQESLMKLVEACnd----qsHNMDRWLNKLENSKWLSHNK 309  coelac...
Q965W9               246 TRSKSSATAAKAKGG-GAEPqg-nYRQWRYIQCPIPRQREIHDALTRMVDVCse----rkVTSDRWVSRVGQAGWLSSVA 319  Caenor...
XP_017946599         260 TRSAQEAKQARNEGG-GTESks-rYRNWRVLHRPLERGHALQDSLVRLVVTCyd----psIGMTRWLSKLQAARWLSHVK 333  tropic...
XP_014348815        1305 QRAALYIIGDKSQLK-G-VKqdplQQ-WEVVPIEVFDVRQVKASFKKLIKACipscvptdPGSGTYYRSLEESEWLSQLH 1381 coelac...
4Y7I_B               194 AIMDAGIFITKAV---KVEKASVLVHSSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRC----GH 266  human
Q7KSP6              1411 SLMQLSGAVVDLI---DLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLDGFRVLVEKEWLAFGHRFAHRSnlkpSH 1487 fruit fly
WGS:AAQB:GK14310-PA 1423 SLLQLAGAVVDLI---DLQESSVMLSLEDGSDVTAQLSAIAQLCLDPYYRRLDGFRVLVEKEWLAFGHRFAHRSnlkpSH 1499 Drosop...
EFA77446             776 QILSAAILIATSV---D-QGQSILVQGANNEDADTQLSSISQLLLDGYYRTIEGFKVLIEKEWLVYSNPMARRC----GH 847  Hetero...
XP_003228769         312 ESLGTACLAAQCM---EREEACVLVHGAEGMDTTLLVTALAQVILDPCRRTMAGFQELLEQEWIQAGHPFHLRC----AR 384  green ...
XP_005317803         314 EALSTACLAAQGM---EREGACILVHGAEGRDSTLLVTSLAQLILDPLSRTITGFQELVEREWIQAGHPFQLRC----AH 386  thirte...
XP_006003301         310 AVLTTACLAAQCV---ERENGCVLVHGSEGMDATLQVTSLAQVILDPDSRTIAGFQTLIEREWLQAGHPFQLRC----AR 382  coelac...
Q965W9               320 ASLEAAANVAQCIyneRLEEVPVVIHGGDGLDSTLIASSLAQILLDADARTIRGFESVIEREWICGGHPFSLRN----NH 395  Caenor...
XP_017946599         334 EALSTAGLIAECI---ERECANVLVHGEDGTDNTLLLTSLAQLILCPESRTMDGFQDLIEREWLQAGHPFQLRC----AQ 406  tropic...
XP_014348815        1382 KILQVSVLVVELL---D-TGSSVLVSLEDGWDITTQVVSLVQLLSDPYYRTLEGFRLLVEKEWLSFGHRFSHRG----AQ 1453 coelac...
4Y7I_B               267 LD----G------DSKE---VSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDRE 327  human
Q7KSP6              1488 ANtn--------------iaFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERS 1547 fruit fly
WGS:AAQB:GK14310-PA 1500 AStn--------------iaFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHVVSCRFRTFLFDCELERS 1559 Drosophila w...
EFA77446             848 DLvkvrSpgqqevGLDQ---YSPTFIQFIFIVWQLWKEFPSAFQFNENYLLTLVDSVYTCRFGTFLGNSLRERD 918  Heterosteliu...
XP_003228769         385 SAy---------sHARLk-qESPVFLLFLDCVWQLGRQFPLSLEFNEAFLLALFEHSYASPYGTFLCNNEKERK 448  green anole
XP_005317803         387 SAfs-hA------RPKH---EAPTFLLFLDCVWQLGRQFPLSLEFGEGLLLALFEHAYASPFGTFLCNSEKERC 450  thirteen-lin...
XP_006003301         383 SAy---------sHAKPk-hEAPIFLLFLDCCWQIIRQFPCSFEFNERFLIMLSQQAFASQFGTFLCNNEKERY 446  coelacanth
Q965W9               396 CAya--------eGTVTgpfESPVFLVFLDAVHQMIAQYPMSFEFDENFLIFLFEHAYASEFGSFLGNCEKEKK 461  Caenorhabdit...
XP_017946599         407 SGw---------sQSRAq-qESPHFLLFLDCCWQLGRQFPRALEFNERFLCTLATHAYSSEYGSFLCNNEKERC 470  tropical cla...
XP_014348815        1454 TL-----------ASQSs-gFAPVFLQFLDCVHQIHLQFPMEFEFSQYYLKFLAYHYVSNRFRTFLLDSDYERI 1515 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap