Conserved Protein Domain Family
Myotub-related

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pfam06602: Myotub-related (This model is not part of the current CDD release)
Myotubularin-like phosphatase domain
This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.
Statistics
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PSSM-Id: 517348
Aligned: 180 rows
Threshold Bit Score: 316.744
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_036665151  161 LYAYAYVPnnLEKKLD----TRGWDIYDPVA--------EYTRLGLipnesdKQFWRMTEVNADYK-FCPSYPCKFIVPN 227 
XP_007257642  109 MYPFFHRP--RELSL-----KDPRGLSSPEQ--------DYTQTErlw-----drWRLSKVNSDFS-VCPSYPDTLIVPS 167 
XP_417799     113 MYPFFHRP--QSLRL-----EEGWPLLPVEQ--------YFQQLALqt-----tqWRLSDVNRDFA-VCPTYPPAVIVPA 171 
XP_003228769  109 MYPFFYR------PQSmrlaGGGRQPHALEK--------YYQQVasr-----tgaWRLSVVNEDFQ-ACPSYPALVVVPS 168 
XP_028936254  116 SYPFFYRP--QTMKL-----EDGWRLYPYDL--------YYQRVSret-----daWRLSTVNADFR-VCASYPPSVIVPS 174 
XP_005317803  109 SFPFFYRP--KGLRL-----GDAWHFHPPEC--------YYKRVAret-----naWRLSEVNQDFS-LCPSYPRAVIVPR 167 
XP_020429574  497 VFAFASQE--NT-------------IDASENfcqrlipgEFDRQGVsw---dE--WCVNTTNSQLKlNTMSYPPASVIPK 556 
Q7KSP6       1137 MRERSYV----Q---------------------------DWKRLGFda--esQRGFRISNANTSYA-TCRSYPAIIVAPV 1182 fruit fly
XP_002073814 1151 MRERSYV----Q---------------------------DWKRLGFda--esQRGFRISNANANYA-LCRSYPAIIVAPV 1196
XP_056651257  108 SYPFFFRP--QSLRL-----GDAEDLYPPDH--------FYQQVALet-----daWRLSTVNRDFQ-VCASYPPALVVPR 166  gray short-ta...
XP_036665151  228 TISDNVLKHAAKFRSKQRIPAVVYKHKSniNGNVIARCAQP----LVGLn------------------------------ 273 
XP_007257642  168 SIDDDTLIKAARFRQGGRFPVLCYCHHR--NSMVIMRSSQP----LTGA------------------------------- 210 
XP_417799     172 AVSEETLRRAARFRQGGRFPVLSYYHSR--NGTVMLRSGQP----LTGP------------------------------- 214 
XP_003228769  169 SVDDAALRKSARFRQGGRFPVLSYYHKK--NGTVMLRSSQP----LVGP------------------------------- 211 
XP_028936254  175 GVEDEALVRSARFRQGGRFPVLCYYHGR--TGTAMLRSSQP----LVGA------------------------------- 217 
XP_005317803  168 AVDDDALARSARFRQGGRFPVLCYHHAP--SGTVLLRSSQP----LTGP------------------------------- 210 
XP_020429574  557 SVSQNIVVASSLFRSL-RFPVLVWHHPT--NRACITRAASPsndaSNSLspptsaplsprsgsnnninnnnnsnssnnsn 633 
Q7KSP6       1183 QCSDAAIMHLGRCFKGQRIPLPTWRHA---NGALLIRGGQPnsksVIGMlknttgs------------------------ 1235 fruit fly
XP_002073814 1197 QCSDATMTHLGRYFKGQRIPLPTWRHQ---NGALLIRGAQPnsksVIGMlknttgantmt-------------------- 1253
XP_056651257  167 GIGDEVLARSAHFRQGGRFPVLSYYHST--NGTVMLRSSQP----LQGA------------------------------- 209  gray short-ta...
XP_036665151  274 ---------------LQNR----------------------------------------SIQDEKLIGE-IFHcqdverg 297 
XP_007257642  211 ---------------NRKR----------------------------------------CREDELLLQA-VIDe------ 228 
XP_417799     215 ---------------NRKR----------------------------------------CAEDEMLLGS-VLDd------ 232 
XP_003228769  212 ---------------HRKR----------------------------------------CPEDEGLLAAaLDG------- 229 
XP_028936254  218 ---------------NRRR----------------------------------------CREDEELLGA-VLGg------ 235 
XP_005317803  211 ---------------QKRR----------------------------------------CAEDEDLLRA-VLAgah---- 230 
XP_020429574  634 snsshssnnntsssnSNSNsnsgmssstsstnlnifnslghplspshslssnqlsnpnpCNEDIDFIRAiIDN------- 706 
Q7KSP6       1236 ---------ttnahhDVTH----------------------------------------YPEQDKYFLA-LINtmpkltp 1265 fruit fly
XP_002073814 1254 ----hhhhhhlhhphDVSH----------------------------------------YHEQDKYFMA-LINtmpkmal 1288
XP_056651257  210 ---------------NRRR----------------------------------------CAEDEELLRA-ALAlg----- 228  gray short-ta...
XP_036665151  298 fr---------------------------------------------lksaevdeAFeyqsqqtQRNLLVDLRPVTNAMA 332 
XP_007257642  229 --------------------------------------------------------S-------EMGYVVDTRSAQQAQQ 245 
XP_417799     233 --------------------------------------------------------G-------ERGFIIDTRSAQAAKQ 249 
XP_003228769  230 --------------------------------------------------------R-------SRGFVLDTRSAQAAKQ 246 
XP_028936254  236 --------------------------------------------------------H-------RRGYVLDTRSTQAAKQ 252 
XP_005317803  231 --------------------------------------------------------------pgARGFIVDTRSAQAAKQ 248 
XP_020429574  707 --------------------------------------------------------Gk-----sSLLTVYD----IGTVA 721 
Q7KSP6       1266 lalnqysgmnlsmsslmghsssddrqpltpelsrkhknnldisdgnkssqggkggTMkgnpknsLAHPFRKMR--LYALG 1343 fruit fly
XP_002073814 1289 nqysglnlsmssllghged-----------hhahhhhhhaqqpmtpevtrkhegkSStmkgtsaAPLGFRKMR--LYALG 1355
XP_056651257  229 ---------------------------------------------------------------gQRGLVLDTRSAQAVKQ 245  gray short-ta...
XP_036665151  333 QHALGA-GTENVDN-YRnkkptgnddsngddnnnshhsrspRqVDKIFCNIDNIHVVRD-------SLTKLTTILNDLdr 403 
XP_007257642  246 ARMTGG-GFESKSC-YQ------------------------N-WKRLHRHMERGKVLQE-------SLIKLVEACGDP-- 289 
XP_417799     250 ARMTGG-GTEPKSS-YPq-------------------------WKRLHRPLERGRPLQE-------SFIKLVEACNDA-- 293 
XP_003228769  247 AKMMGG-GTEHRSA-YA------------------------G-WKRMHRALDRGRPLQE-------SFVKVVETCNDP-- 290 
XP_028936254  253 ARVTGG-GTEAKSC-YL------------------------G-WKRLHRPLERGRPLQD-------SFTKLVESCNDP-- 296 
XP_005317803  249 ARMTGG-GTEAKAA-YPg-------------------------WKRLHRPLERGRALQE-------SFVRLVEACGDP-- 292 
XP_020429574  722 SHSSTMiG-----------------------------------CKFEFLNLPPITSVKE-------SFSRLLQ------- 752 
Q7KSP6       1344 EKSQAK-SNMNVDFcAD----------------------------FIPVDYPDIRQSRP-------AFKKLIRACMPSh- 1386 fruit fly
XP_002073814 1356 EKSQAK-SNLNGDFcAD----------------------------FIPVDYPDIRQSRS-------AFKKLIRACMPSh- 1398
XP_056651257  246 ARITGG-GTEAKAA-YP------------------------G-WKRLHRPL-------ErgrplqdSFVRLVEACTDP-- 289  gray short-ta...
XP_036665151  404 fqqpsvpgqaQsSVVAAAALQHSLTKTQWLNRLSIILQSVDRITKSIhLNNTNVIIHCSDGWDRTSQVSALAQLCLDPYY 483 
XP_007257642  290 -------------SHNMDRWLSKLENSKWLTHVHSALSTAGLVAECVeRDSHSVLVHGSEGTDTTLLVTTVAQLILDPAS 356 
XP_417799     294 -------------SLGMDRWLGRLESCRWLSHVKAALSTACLAAQCLdREESSVLVHGAEGTDTTLLVTALAQLILEPGC 360 
XP_003228769  291 -------------SLTMDRWLSKLEASKWLTHVKESLGTACLAAQCMeREEACVLVHGAEGMDTTLLVTALAQVILDPCR 357 
XP_028936254  297 -------------SLSMDRWLSRLEASKWLAHVKEALGTACLAAQGMdREGACILVHGPEGTDTTLLVTALAQVILDPDC 363 
XP_005317803  293 -------------EQSMDRWLSRLEGCRWLAHVKEALSTACLAAQGMeREGACILVHGAEGRDSTLLVTSLAQLILDPLS 359 
XP_020429574  753 ----------LhNGHPDKKWPDVIR-FHWLNPLKQILSAAILIATSVd-QGQSILVQGANNEDADTQLSSISQLLLDGYY 820 
Q7KSP6       1387 ----------NtNEADGQSFAKMVEQSDWLQQISSLMQLSGAVVDLIdLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYY 1456 fruit fly
XP_002073814 1399 ----------IaNDADGQSFAKMVEQSDWLQQISSLLQLAGAVVDLIdLQESSVMLSLEDGSDVTAQLSAIAQLCLDPYY 1468
XP_056651257  290 -------------SLSMDRWLSRLDGCRWLTHVKEALTTACLVAQGMdREGVCFLVHGAEGTDATLLVTSLAQLILDPKC 356  gray short-ta...
XP_036665151  484 RTMKGFMVLIEKEWVSFGFKFNTRA----DHGGcigavmkkeskkphkqvsqlregnksgdevsselsidslqlenklas 559 
XP_007257642  357 RTFRGFLELLEKEWVQAGHPFQLRC----ARSAys--------------------------------------------- 387 
XP_417799     361 RTLKGFQGLLEREWIQAGHPFHLRC----AHSAysh-------------------------------------------- 392 
XP_003228769  358 RTMAGFQELLEQEWIQAGHPFHLRC----ARSAys--------------------------------------------- 388 
XP_028936254  364 RTLRGFQALLEREWIQAGHPFQLRC----ARSAysh-------------------------------------------- 395 
XP_005317803  360 RTITGFQELVEREWIQAGHPFQLRC----AHSAfsh-------------------------------------------- 391 
XP_020429574  821 RTIEGFKVLIEKEWLVYSNPMARRC----GHDLvkvrsp----------------------------------------- 855 
Q7KSP6       1457 RSLDGFRVLVEKEWLAFGHRFAHRSnlkpSHANtn--------------------------------------------- 1491 fruit fly
XP_002073814 1469 RRLDGFRVLVEKEWLAFGHRFAHRSnlkpSHAStn--------------------------------------------- 1503
XP_056651257  357 RTMHGFQSLLEREWIQAGHPFQQRC----AHSAyaq-------------------------------------------- 388  gray short-ta...
XP_036665151  560 eatsgaagsaagvtataaaasvtsflqkaaraardiknsaqnglsnypdgntnynrpnspdsntdkpfysttssiysgSN 639 
XP_007257642  388 ----------------------------------------------------------------------------haRL 391 
XP_417799     393 ----------------------------------------------------------------------------arLK 396 
XP_003228769  389 -----------------------------------------------------------------------------hAR 391 
XP_028936254  396 ----------------------------------------------------------------------------arPK 399 
XP_005317803  392 ----------------------------------------------------------------------------arPK 395 
XP_020429574  856 ------------------------------------------------------------------------gqqevgLD 863 
Q7KSP6            --------------------------------------------------------------------------------      fruit fly
XP_002073814      --------------------------------------------------------------------------------     
XP_056651257  389 ----------------------------------------------------------------------------grPK 392  gray short-ta...
XP_036665151  640 E--RSPVFHQFLDCIYQIVRQHPTKFEFNTRFLKRLLYHYYSCQYGSFLCDSERELL 694 
XP_007257642  392 Rq-ECPSFLLLLDCVWQLWRQFPLALEFSEALLLRLAQEAYASDYGTFLCNNEQERG 447 
XP_417799     397 Q--EAPLFLLFLDCVWQLSRQFPFSLEFSEGLLLTLFDNAYASDYGTFLCNNEKERC 451 
XP_003228769  392 LkqESPVFLLFLDCVWQLGRQFPLSLEFNEAFLLALFEHSYASPYGTFLCNNEKERK 448 
XP_028936254  400 H--EAPTFLLFLDCVWQLSRQFPLALEFGEGLLLTLFEHAYASPYGSFLCNSEKERC 454 
XP_005317803  396 H--EAPTFLLFLDCVWQLGRQFPLSLEFGEGLLLALFEHAYASPFGTFLCNSEKERC 450 
XP_020429574  864 Q--YSPTFIQFIFIVWQLWKEFPSAFQFNENYLLTLVDSVYTCRFGTFLGNSLRERD 918 
Q7KSP6       1492 -iaFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTFLFDCELERS 1547 fruit fly
XP_002073814 1504 -iaFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHVVSCRFRTFLFDCELERS 1559
XP_056651257  393 H--EAPTFLLFLDCVWQLSRQFPLSLEFGEGMLLALFEHAYASPFGTFLCNSEKERY 447  gray short-tailed opossum
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