Conserved Protein Domain Family
His_kinase

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pfam06580: His_kinase (This model is not part of the current CDD release)
Histidine kinase
This entry represents a long helical region within bacterial histidine kinase enzymes which connects the C-terminal kinase domain to the other domains composing the protein. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.
Statistics
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PSSM-Id: 517341
Aligned: 1190 rows
Threshold Bit Score: 32.0382
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013997105  769 SEVETIQSQMNPHFVYNVLANVQSK----IRnlQTEQAENVLLKLAGLMRKFL---H-TSTvtttqkedtlqikqHLVsL 840  Capnocytophag...
WP_014296494  363 EKLRELMANLSPHFLFNTLNAIKYIs---KK--EPEKVNKFIDDLSELLRYTLyen-----------------stYVT-L 419  Marinitoga
WP_012002618  313 AMMRDFMSKLGPHFIFNTLASIRYLt--vNN--AND-AVKMIDNLSELLRYYFk-nQ-K-T---------------FVsL 369  Pseudothermot...
WP_015868479  362 ARYRQLVAKTDPHFLFNILNALAYLt---rH--DSEKAREMILKLSEMMRYTLr-eK-RTF---------------VP-L 418  Kosmotoga ole...
79_pfamImport   1 LQLQALQSQIQPHFIINTIYSFITLnq----igEQEALNDAFYSFAHLLRYVLsr--sRE----------------TT-L 57  
WP_014624945  444 MEYETLQSQISPHFLFNVLTCLLALn--rMK--EHVAVEQAIFSLKGLLRYTI---E-SKA---------------VVpL 500  Spirochaeta t...
WP_013768886  330 LALMGLRARLNPHFLFNTLGSIQDLm--nQN--NLDAANRYFSEMAELLRYVVd--S-ASNd-------------YVL-L 388  Haliscomenoba...
WP_013766674  341 MALSGLRAQLNPHFLFNTLTSIQDLv--nQE--NKSAANRYFNEMAQLLRYVVd--S-SAEe-------------YTS-L 399  Haliscomenoba...
WP_014855558  168 VELTDTHSKIQPELIDYALVKIKLLivnsKYelAEELL--Te--LSDYIRLILyneEnN-----------------ID-V 225  Melioribacter...
WP_015894149  164 AELEALRGRLDPHFLFNTLHSLMALs---rL--DPARTEQALGQLSDLLRYVLdskR-GARe-------------QVQ-L 223  Gemmatimonas ...
WP_013997105  841 SYELVLLQEFIDFQQMLYPNSF 862  Capnocytophaga canimorsus
WP_014296494  420 NKELTFTKNYLSLMKLRFKDKI 441  Marinitoga
WP_012002618  370 NEEIKIIECYLSIMKARYGDIL 391  Pseudothermotoga lettingae
WP_015868479  419 DDELSFVRNYLQLMKIRFGELL 440  Kosmotoga olearia
79_pfamImport  58 GAELDFLNDYCSLCLLRFGNRL 79  
WP_014624945  501 RDELGFIEDYLRLQQLRFGERL 522  Spirochaeta thermophila
WP_013768886  389 RDELNALEKYCSLEALRT--PF 408  Haliscomenobacter hydrossis
WP_013766674  400 AAELAALEKYCSLEALRT--PF 419  Haliscomenobacter hydrossis
WP_014855558  226 DSQVLLIKKYIGLRKILYdeni 247  Melioribacter roseus
WP_015894149  224 ADELHFVRTYLALEALRYGERL 245  Gemmatimonas aurantiaca
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