Conserved Protein Domain Family
Churchill
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pfam06573: Churchill (This model is not part of the current CDD release)
Churchill protein
This family includes animal Churchill proteins and similar sequences. Churchill shows a a highly unusual solvent -exposed five-stranded beta-sheet, stabilised by the coordination of three zinc ions, including a zinc binuclear cluster.
Links
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Statistics
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PSSM-Id: 517337
Aligned: 11 rows
Threshold Bit Score: 170.265
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004346409   1 MCRNCLKEDTPARGTTCLDTGAYLVNFKGCAQCQSFEFPREQDRkVDEDDEtGEETVTFTHVCKQCNHVIAEHNYTFEIE 80 
Q4T7L7         1 MCNECVQKEYPDRGNTCLEDGSYLMNYVGCASCHQRDFVLISNK-ATEEDD-GEEIVTYDHVCKNCDHVIASHEYTFSVV 78  spotted green p...
EFX73001       1 MCESCLKEEYPNRDRMCLDSGAYMANLKCCCKCQSNQ-VSVLNK-TISEDD-GIEVTVFEHACGTCQHIISIHNYKFWVE 77 
XP_002115762   1 MCNRCVFTPFPDRGNSCLDTGSFFLNFKACSSCQKRTLIETCNKeSKEEED-QTEVIKYQHICPNCRHVIANHEYTFQVE 79 
ABN70841       1 MCRDCVKQQLPDRGNMCLDNGSYLWNFQGCKECGQKDPVKIVDRqTTEDED-GEETITYKHECVHCGHVVAEHEFTFRV- 78 
XP_003726593   1 MCGECVKSKCPDRGNICLDNGSYILNFAHCAECQKREPIKIAQRnVEVKDD-GEEVISYEHKCTHCCHVIAEHEHTFSIE 79 
XP_012404211   1 MCGDCVEKEYPNRGNTCLENGSFLLNYIGCAMCNKRDFMLIANK-SMKEED-GEEIVTYDHVCKNCHHIVARHEYTFSVM 78 
Q9DFZ3         1 MCGGCVGTEYPERGTTCLEGGSFLLNFVGCARCGRRDFVLLGNR-AAGLHG-DDEIITYDHLCKNCHHLIARHEYTFSVV 78  chicken
Q66JD9         1 MCGGCVQEEYPDRGSTCLETGSFLLNYVSCVQCNKRDFVLIVNK-TAEEED-GEEIITYDHMCKNCHHVIAKHEYTFSVV 78  tropical clawed...
XP_005991558   1 MCRACVQREYPDRGKTCLENGSFLLNYVCCAVCSKRDFVLITNK-AIEEED-GEEIVTYDHVCKNCHHVIARHEYTFTVV 78  coelacanth
XP_003386737  17 MCKDCLKEICPNRGNVCLETGSYLLNYSGCASCKSLSFILIKEKnVAEEEN-GDETVTYNHTCNECGHLIASHEYTFTLD 95  Amphimedon quee...

XP_004346409  81 DGYQEYTMECQLCGTADDTASVLPDDPRKAQTL 113
Q4T7L7        79 DEYQEYTMLCLLCGKAEDSISVLPDDPRQSAPL 111 spotted green pufferfish
EFX73001      78 GDYQEYEMDCALCGTAEDSISILPDDPRKASld 110
XP_002115762  80 EGYQIYGMECLLCGCGEATVSVMPNDPRKllin 112
ABN70841      79 GDSQDYSMSCLLCGEGTDQRNIFPENQYRQNGV 111
XP_003726593  80 GEYQEYAMYCMLCGVGSDTVSVLPVDPRKEMTL 112
XP_012404211  79 DEYQEYTMLCLLCGKAEDSISVLPDDPRQMAPL 111
Q9DFZ3        79 DDYQEYTMLCLLCGRAEDSVSILPDDPRQMTPL 111 chicken
Q66JD9        79 DDYQEYTMLCMLCGRAEDSVSVLPDDPRQMAPL 111 tropical clawed frog
XP_005991558  79 EDYQEYSMLCLLCGKAEDSISVLPDDPRQMAPL 111 coelacanth
XP_003386737  96 EEFQEYSMNCALCGYGSDTVSILPDDPREKqlf 128 Amphimedon queenslandica
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