Conserved Protein Domain Family
SecM

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pfam06558: SecM 
Secretion monitor precursor protein (SecM)
This family consists of several bacterial Secretion monitor precursor (SecM) proteins. SecM is known to regulate SecA expression. The eubacterial protein secretion machinery consists of a number of soluble and membrane associated components. One critical element is SecA ATPase, which acts as a molecular motor to promote protein secretion at translocation sites that consist of SecYE, the SecA receptor, and SecG and SecDFyajC proteins, which regulate SecA membrane cycling.
Statistics
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PSSM-Id: 399513
View PSSM: pfam06558
Aligned: 17 rows
Threshold Bit Score: 128.631
Threshold Setting Gi: 506350439
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8ZIE1           24 MVAASLGVPLnLSGVPDHAALANTSS-SQSRQNHGTTNFN-----SLALLHDIHR-RL--SFSVDYWQQHALRTVIRHLS 94  Yersinia pestis
WP_013200764     24 MVAAGLGLPH---AASDRTTLPETASrSLNISN--GVRFD-----SLALLQESVR-RP--NFNVDYWHQHAIRTVIRHLS 90  Erwinia bill...
jgi:Rahaq2_3818  24 MVAASLGVSTnLSQT-ELPAVPNTSS-SLNRLNIASTGLS-----NLALLQ-ANR-RP--SFGVDYWQQHALRTVIRHLS 92  Rahnella aqu...
B4F103           23 MVAAGIGMPSlVSAHAENPSQTDTPS-SQNRQSQALIAFD-----NLFLRQSVQ--NPasSFTFNYWQQHAVKNVIKQLS 94  Proteus mira...
CCH:MU9_3050      1 -mATGFGLPAvLN--SGDVTTAGTGT-TQNRQSQALSAFD-----SLF-LQSSQPaRTsqN--VNYWQQHAVRNVIRQIS 68  Morganella m...
Q7N155           23 VVAASIGAPTiLAGVTDNISQANTSP-SQSWQNQALSAFD-----NLFSLQNVQH-QPanG--VNYWQQHAVRNVIRQLS 93  Photorhabdus...
CBJ82586         23 MVATGIGVPAvLAGITESLPHSNTSS-SQKNQNQVFSSFD-----HLFQLQSVQR-QPsnH--LNYWQQHAVRNIIRRLS 93  Xenorhabdus ...
WP_013183644     23 fVATGIGVPTaFAKVAENLPHTNTSS-SQENQHQAFSSFEhlfqlHLFQLKSAQR-QPstY--LNYWQQHAVRNVIRQLS 98  Xenorhabdus ...
Q2NVU4           23 IVAAGFGVPLlPGGGQEMLYQADNCP-SLSRQSAFQAGFS-----QLARLKDVPC-RT--TYAVDYWHQHAIRTVIRHLS 93  Sodalis glos...
Q6D0J1           24 MVAASLGLPTsLNESQDIVSHPNSAS-SVSRQNSVSLSLT-----DLVALKEAHR-RS--SYSVDYWHQHAIRTVIRHLS 94  Pectobacteri...
Q8ZIE1           95 FALAPQAAyarvqeVAETERVAPSKIQQLALLDTLNALLTHEFK-P---PAIIRYTEQVERPVLSPYKPGLWLAQVQGIR 170 Yersinia pestis
WP_013200764     91 FTLTPAN-------QPTAEQVMPLEVQKLALLDTLNGLLTHEAR-P---PTIIRQTSEPQSAAKPRYQTGLWLAQVQGIR 159 Erwinia bill...
jgi:Rahaq2_3818  93 FALAPQVVytvaqpEAEMQKAEPLHVQQLALLVTLNALLTHEPK-P---PVIIRQTQQPFLPLASSHQTGLWLAQVQGIR 168 Rahnella aqu...
B4F103           95 FAFTIHSPel---mVKAKDEPSPVANVAEVMLDTLYALLTQAPSsT---LVNLPISRGVLTENRISYHTGLWLAQIRGIR 168 Proteus mira...
CCH:MU9_3050     69 FAFSCPEDaskdntPAEDRHDAS----AQNMLAALYAILTDSPAlPvyhPAVLPQ--RIAVVNPSPSFSVQWIARTGGIR 142 Morganella m...
Q7N155           94 FAFSISQPmsdetaKQSIRLSSSNI--QQLVLETLNTLLIREPKpP---EPVL-DIPFLNVASQSSYILTLWIAKAQGIR 167 Photorhabdus...
CBJ82586         94 FTFSITGPiqhevaKESIRFSSPCM--QQLMLDTLYAMLIQAPSqF---ESIL-DIEITATILPDSHTPALWVAKTQGIR 167 Xenorhabdus ...
WP_013183644     99 FAFSVTEPvrceeaKESTRISSPSM--QQLMLDTLHAMLIQTPTlL---DDIISDVSRAAAVFPNSYTPALWLAQTQGIR 173 Xenorhabdus ...
Q2NVU4           94 IAWAPAPL---------PEAVAPLRVQHQVLLTTLGLLLNREAR-P---PVLVRRLRSTGHVAFIDNRSGIRLTQQQGIR 160 Sodalis glos...
Q6D0J1           95 FALTTPQ-------TANAQQVDELQPHSLVLLDTLNALLTQDSQfP---FVISPHAGRVTFYPQAHHQIGIWLAQIRGIR 164 Pectobacteri...
Q8ZIE1          171 AGPAN 175 Yersinia pestis
WP_013200764    160 AGPAS 164 Erwinia billingiae
jgi:Rahaq2_3818 169 AGPSS 173 Rahnella aquatilis CIP 78.65 = ATCC 33071
B4F103          169 AGPYL 173 Proteus mirabilis HI4320
CCH:MU9_3050    143 AGPVQ 147 Morganella morganii subsp. morganii KT
Q7N155          168 AGPTA 172 Photorhabdus laumondii subsp. laumondii TTO1
CBJ82586        168 AGPTA 172 Xenorhabdus bovienii SS-2004
WP_013183644    174 AGPLs 178 Xenorhabdus nematophila
Q2NVU4          161 AGPHA 165 Sodalis glossinidius str. 'morsitans'
Q6D0J1          165 AGPYL 169 Pectobacterium atrosepticum SCRI1043
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