Conserved Protein Domain Family
BNIP3

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pfam06553: BNIP3 
BNIP3
This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localization, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.
Statistics
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PSSM-Id: 399510
View PSSM: pfam06553
Aligned: 21 rows
Threshold Bit Score: 200.365
Threshold Setting Gi: 82249468
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003435820  35 G------PEE-LGESWIELSSNTNTGATsGlvgagttaavvgggss---nnfvptgttmlagavgTKSPDRTTPLAFAS- 103 Anopheles gambi...
XP_003445727   5 TaqqnnnEEPgLQGSWVELELNGNTAAQgRqtnlltppaadqinanagmsqtlqtlevvpesdetLIGGLEHVPSSSSIh 84  Nile tilapia
NP_991134      5 AapadnnGEPgLNGSWVELEMNRNAA---Slsssiasvppp--------------laqvveeddgMVGGLEHVPSSSSIh 67  zebrafish
XP_003978419   6 NsttdnnGDAgLNGSWVELEMNRGAAGSvQststtgpaavl-------------lplpqveeeeaMVGGLEHVPSSSSIh 72  torafugu
XP_006625864  15 aaqqnnnEEPgLNGSWVELEMNGNTGVAhPpsssngn----------------------egedehNGGGLEHVPSSSSIh 72  spotted gar
EEB14955       5 PksnnklTDEiLGDSWVELNTTGNG-----------------------------------------STPDRVTPLPFTS- 42  human body louse
XP_393165      6 Vkf---tSDEsLGESWVELN----------------------------------------------PVPDRITPLPFSSg 36  honey bee
XP_002048105   5 Pt----sTEDlLGESWIELSTTAAMAGI--------------------------------------KSPDRITPLPFSN- 41  Drosophila virilis
Q175B2        18 Pr----sSEDlLGESWIELSSSTNTCP---------------------------------------KSPDRTTPLPFTS- 53  yellow fever mo...
XP_001605739   5 Gkf---aSDEtLGESWVLCP----------------------------------------------TPVDRVTPLPFGSg 35  jewel wasp
XP_003435820 104 VEEYIRLLREAQRdESKESsrvaSLTSTrkNSPRgsPKSPp------------------nSPNTELAATEEDlrnvyiny 165 Anopheles gambi...
XP_003445727  85 NGDMEKILLDAQH-ESSPS----NSSCD--SPHR--PPSPeqdegqitf--dvemssprgSQSEEDCAEKDR-------- 145 Nile tilapia
NP_991134     68 NGDMEKILLDAQH-ESSRS----NSSCD--SPPR--PHSPqdegqiif-------dvdtrrdSQEEVMEKIR-------- 123 zebrafish
XP_003978419  73 NGDMEKILLDAQH-ESSRS----NSSCD--SPPR--PHSPqdegqlifh---vdvagrrdSQSEEEVVDKER-------- 132 torafugu
XP_006625864  73 NGDMEKILLDAQH-ESSQS----SSSCD--SPPR--PHSPqdegqitfdvemhsgrdngsTQSEEEGLEKER-------- 135 spotted gar
EEB14955      43 GEEYLRLLREAQR-ESNQSsarvSLASSrrDSPRdsPKSPp------------------nSPNTEL-NTEDEfrgvyiny 102 human body louse
XP_393165     37 GEEYLRLLREAQR-DSLPSsarhSLASSrrGTPRdsPKSPp------------------nSPNTEL-STEDElkgvyiny 96  honey bee
XP_002048105  42 GEEYLRLLREAQR-ESNQSsrvvSLASSrrDTPRdsPKSPp------------------nSPQSEL-CPDDElrnvyiny 101 Drosophila virilis
Q175B2        54 VEEYLRLLREAQR-ESKESsrvaSLTSSrrDSPRgsPKSPp------------------nSPNTELATTEEElrgvyiny 114 yellow fever mo...
XP_001605739  36 GEEYLRLLRDAQR-DSTHSsarhSLASSrrDTPRdsPKSPp------------------nSPNTEL-STEDElkgvfi-- 93  jewel wasp
XP_003435820 166 vnkdGDIV---KDTDWVWDWSSRPDQQPPKDWKFEHPNqtqeernKpiHAGYSIRQVRVGKNS-LFSREFLYSIVLTNVL 241 Anopheles gambi...
XP_003445727 146 ----EEDIlmnKEVDWVADWSSRPENIPPKEFHFRHPR-------R--SVSLSMRKSGVMKKGgIFSAEFLKVFIPSLLI 212 Nile tilapia
NP_991134    124 ----DDDIl-mKDSDRMADWSSRPENIPPKEFHFRHPR-------R--SVTLSMRKTGAMKKGgIFSAEFLKVFIPSLLL 189 zebrafish
XP_003978419 133 ----DMDIl-mKDADWVADWSSRPENIPPKEFNFRHPR-------R--SVMLSMRKTGAMKKGgIFSAEFLKVFIPSLVL 198 torafugu
XP_006625864 136 ----EDDIlmkKSADWVADWSSRPENIPPKEFHFRHPK-------R--SVTLSMRKTGAMKKGgVFSAEFLKVFIPSLLL 202 spotted gar
EEB14955     103 lckdGV-LnldSNSDWIWDWSSRPEQAPPKDWKFKHPK----------RKTYSIRNAKVGRNS-LFSKEVLYTLFITNFI 170 human body louse
XP_393165     97 ccnkESEFl-eKNTDWIYEWSSRPDQAPPKDWKFKHPQg------MnkRKSYSIRTTKVGKIG-LFSKEVLYTLVITNIL 168 honey bee
XP_002048105 102 wtknGDKQnt-dNGDWLQNWNRGADEQPPKDWKFERSNdde--eeKkkSSGYSIRLKRLGANS-LFSREILYSLLVTNVL 177 Drosophila virilis
Q175B2       115 lnreGAATsaqKDTDWVWEWSSRPDQLPPKDWKFEHPKqd----vRrmQQGYSMRLTRVGKNS-LFSREVLYSLVLTNVL 189 yellow fever mo...
XP_001605739  94 nhtchkDVdldKSTDWIYEWNTKPEPIGPKDWKLKHQLg------MgrRKTYSIRTAKVGKNG-LFSKEVLYTLFLTNIL 166 jewel wasp
XP_003435820 242 SLLLGAGIGAWLQKRGLLLTRVS 264 Anopheles gambiae str. PEST
XP_003445727 213 SHILALGLGVYIGKRIATAATSS 235 Nile tilapia
NP_991134    190 SHILVLGLGVYIGKRLTTPPASS 212 zebrafish
XP_003978419 199 SHILALGLGVYIGKRLTTPPASS 221 torafugu
XP_006625864 203 SHILALGLGVYIGKRLTSPSASS 225 spotted gar
EEB14955     171 SLLLGTGVGLWLSRRGLIIpkin 193 human body louse
XP_393165    169 SVLVGAGLGVWLSRRGSITTSVT 191 honey bee
XP_002048105 178 SLLLGAGFGLWLSKRGILLTRVV 200 Drosophila virilis
Q175B2       190 SLLLGAGIGAWLHKRGLLFTRIS 212 yellow fever mosquito
XP_001605739 167 SLIIGTGIGVWLTRRGLMVSRVT 189 jewel wasp
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