Conserved Protein Domain Family
BNIP3
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pfam06553: BNIP3 (This model is not part of the current CDD release)
BNIP3
This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerization, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation.
Links
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Statistics
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PSSM-Id: 517329
Aligned: 17 rows
Threshold Bit Score: 196.484
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5VK49        13 EEPgLNGSWVELEMNGNTQHQsPslpsllgngnqgepq---tsqaleavqeeeevLTGGLEHVPSSSSIhNGDMEKILLD 89  zebrafish
1_pfamImport   1 PEE-LGESWIELSSNTNTGATsGlvgagttaavvgggssnnfvptgttmlagavgTKSPDRTTPLAFAS-VEEYIRLLRE 78 
XP_006630463   9 QDEnLQGSWVELHFNNNGNGSvT--------------------------------QNGGQDQVPA--SIhNGDIENMLLD 54 
XP_005804941   9 SDEsLQGSWVELHFSGTGSQGtS--------------------------------HRGSQEHIPT--SSqEGDVEKMLLE 54 
4_pfamImport   1 TNDfLTGSWLELHFSTNGSNGgT--------------------------------QSGGREQVPASTSIhNGDMEKMLLD 48 
XP_007962643  79 QEEsLQGSWVELHFSNNGNGSs----------------------------------------VPASVSIyNGDMEKILLD 118
XP_393165     10 SDEsLGESWVELN-------------------------------------------PVPDRITPLPFSSgGEEYLRLLRE 46 
XP_002427693  12 TDEiLGDSWVELNTTGNG--------------------------------------STPDRVTPLPFTS-GEEYLRLLRE 52 
XP_002048105   8 TEDlLGESWIELSTTAAMAGI-----------------------------------KSPDRITPLPFSN-GEEYLRLLRE 51 
Q175B2        21 SEDlLGESWIELSSSTNTCP------------------------------------KSPDRTTPLPFTS-VEEYLRLLRE 63  yellow fever mo...

Q5VK49        90 AQH-ESSPS----SSSCN--SPPR--PHSPdqdegqimf-dvempserdCQSEDDSMEKDK------------EDDIlmn 147 zebrafish
1_pfamImport  79 AQRdESKESsrvaSLTSTrkNSPRgsPKSPp-----------------nSPNTELAATEEDlrnvyinyvnkdGDIV--- 138
XP_006630463  55 AQH-ESGRSssrgSSHCD--SPPR--SQTPlhlrrgsev--hssgeknsSQSEEDYLERRR------------EVENimk 115
XP_005804941  55 AQH-ESGRSsskgSSQCN--SPLR--SQTPlllwrg--------segnsSQSDEDFQERRR------------EVESlmk 109
4_pfamImport  49 AQH-ESGRSssrgSSHCDrfSPPR--SQTPqhlrrgsemevqsngernsSQSEEDYLERKK------------EVENimk 113
XP_007962643 119 AQH-ESGRSss-kSSHCD--SPPR--SQTPqdtnrasetdthsigeknsSQSEEDDIERRK------------EVESilk 180
XP_393165     47 AQR-DSLPSsarhSLASSrrGTPRdsPKSPp-----------------nSPNTEL-STEDElkgvyinyccnkESEFl-e 106
XP_002427693  53 AQR-ESNQSsarvSLASSrrDSPRdsPKSPp-----------------nSPNTEL-NTEDEfrgvyinylckdGV-Lnld 112
XP_002048105  52 AQR-ESNQSsrvvSLASSrrDTPRdsPKSPp-----------------nSPQSEL-CPDDElrnvyinywtknGDKQnt- 111
Q175B2        64 AQR-ESKESsrvaSLTSSrrDSPRgsPKSPp-----------------nSPNTELATTEEElrgvyinylnreGAATsaq 125 yellow fever mo...

Q5VK49       148 KGESWVADWSSRPENVPPKEFHFRHPK-------RsgSVSLSMRKSGAMKKGgVFSAEFLKVFMPSLLLTHILALGIGVY 220 zebrafish
1_pfamImport 139 KDTDWVWDWSSRPDQQPPKDWKFEHPNqtqeernKpiHAGYSIRQVRVGKNS-LFSREFLYSIVLTNVLSLLLGAGIGAW 217
XP_006630463 116 KNADWIWDWSSRPENAPPKEFLFKHPK-------R--SATLSMRNTSVMKKGgIFSAEFLKVFLPSLFLSHILAVGLGIY 186
XP_005804941 110 KNADWIWDWSSRPENSPPKEFLLKYPK-------H--STSLSIRNTSVMKKGgILSADFLKIFLPSLIISHILALGLGIF 180
4_pfamImport 114 KNADWIWDWSSRPENIPPKEFLFKHPK-------R--TATLSMRNTSVMKKGgIFSAEFLKVFLPSLLISHLLAMGLGIY 184
XP_007962643 181 KNSDWIWDWSSRPENIPPKEFLFKHPK-------R--TATLSMRNTSVMKKGgIFSAEFLKVFLPSLLLSHLLAIGLGIY 251
XP_393165    107 KNTDWIYEWSSRPDQAPPKDWKFKHPQg------MnkRKSYSIRTTKVGKIG-LFSKEVLYTLVITNILSVLVGAGLGVW 179
XP_002427693 113 SNSDWIWDWSSRPEQAPPKDWKFKHPK----------RKTYSIRNAKVGRNS-LFSKEVLYTLFITNFISLLLGTGVGLW 181
XP_002048105 112 dNGDWLQNWNRGADEQPPKDWKFERSNdde--eeKkkSSGYSIRLKRLGANS-LFSREILYSLLVTNVLSLLLGAGFGLW 188
Q175B2       126 KDTDWVWEWSSRPDQLPPKDWKFEHPKqd----vRrmQQGYSMRLTRVGKNS-LFSREVLYSLVLTNVLSLLLGAGIGAW 200 yellow fever mo...

Q5VK49       221 IGKRLSTPPSST 232 zebrafish
1_pfamImport 218 LQKRGLLLTRVS 229
XP_006630463 187 IGRRLTTSTSTF 198
XP_005804941 181 IGKRLTSHNT-Y 191
4_pfamImport 185 IGRRLTTSTSTF 196
XP_007962643 252 IGRRLTTSTSTF 263
XP_393165    180 LSRRGSITTSVT 191
XP_002427693 182 LSRRGLIIPKIN 193
XP_002048105 189 LSKRGILLTRVV 200
Q175B2       201 LHKRGLLFTRIS 212 yellow fever mosquito
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