Conserved Protein Domain Family
Vert_HS_TF

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pfam06546: Vert_HS_TF (This model is not part of the current CDD release)
Vertebrate heat shock transcription factor
This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress. This C-terminal region is found with the N-terminal pfam00447, and may contain a three-stranded coiled-coil trimerisation domain and a CE2 regulatory region, the latter of which is involved in sustained heat shock response.
Statistics
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PSSM-Id: 517327
Aligned: 14 rows
Threshold Bit Score: 256.322
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELV13598     274 YGSSSLFPSD-AVASSGPIISDVTEL-------------SPASPAASPGGSIDERPlS---SSPLVRVKEEPPSPPQSPr 336
6_pfamImport   1 SGSSNLYSPDsSSANSGPIISDVTEL-------------GPSSPSASPGSSIDN---G---RYGTVG--------FEACf 53 
4_pfamImport   1 LNRNEGLKQR-EQISDDIVIYDVTEDvgeeehpmadeenTPVTPETSEDTTSDSSNcScsyHSPDIVIVEDDNEDEYAPv 79 
XP_008118339 248 HNRTDGLKQR-EQMSDDIIIYDITDDdigd------eekAPDTPETSEDTASDSN------YSPDIVIVEDDCEDDYVPv 314
XP_003769453 230 HSRTEGLKPR-EQISEDIIIYDVTDDnid-------eenAPVTPETNEDATSDTSNcS---QYPDIVIVEDDNEDDYATv 298
XP_015212965 252 YTGANLYSAD-SPVNSGPIISDVTDV-------------AQSSPSDTATEWSEE---R---TSPLVHIKEEPDSPVHSPq 311
P38529       252 YSGSNIYSPD-SSTNSGPIISDVTEL-------------AQSSPSASPSGSLDE---R---SSPVVRIKEEPPSPSRSPk 311 chicken
NP_001300665 244 FTGTGVFSSE-SPVKTGPIISDITEL-------------AQSSPVAT-DEWIED---R---TSPLVHIKEEPSSPAHSPe 302 zebrafish
XP_014344337 241 YTGTKLYSSD-SAENLGPIISDVTDL-------------AQSSPCVSPSASTREER-----SSPVIRIKEEPPSPAHSPq 301 coelacanth
Q08DJ8       247 YSGSSLYSPD-AVTSSGPIISDITEL-------------APGSPVASSGGSVDERPlS---SSPLVRVKEEPPSPPQSPr 309 domestic cattle
ELV13598     337 VPATSPGHPPSv-------DTPLSPTALIDSILRESEPAPAASVLRPERKGhwswehsAHSHPG--------CRP---CV 398
6_pfamImport  54 LQWGLKNHHGS-------------------------------------------------KGAP--------------CH 70 
4_pfamImport  80 IQGDKNTESVA---------VPEDPVSVMDSILNENGVI---------------------------------------SQ 111
XP_008118339 315 IQENTNAEPVS-----------IPSPESVGPSTDDTSPLMSSAVQLNSQSV-------LTAEDPvsmmdsilNENgviSQ 376
XP_003769453 299 IQGGDKSSDPT----------SVPITDHESSVIESGSSLMSNAVQVNNSSA-------LTSEDPvsmmdsilNE------ 355
XP_015212965 312 VEEVSPATVAT--------DTPLSPSTFIDSILRDSEAS-------------------TTQPPS--------EEK---CL 353
P38529       312 ----------------------------------ENEPSTTTAAAGN---S-------TEQPQP--------QEK---CL 336 chicken
NP_001300665 303 VEEVCPVEVEVgagsdlpvDTPLSPTTFINSILQESEPVSALT------------------PPPs-------EQK---CL 354 zebrafish
XP_014344337 302 IEEVSVIDTGT--------ESCLSPSTFIDSILQENETSGSSNASTSIDPS-------TAQSQP--------EER---CL 355 coelacanth
Q08DJ8       310 AEGASPGRPSSm------vETPLSPTTLIDSILRESEPTPVASTTPLVDTGgr---ppSPL--Pas-----aPEK---CL 370 domestic cattle
ELV13598     399 PASAVpaTQpsaprv------------------tarpwNELSDHLDAMDSNLDSLQSMLSSPGFSVDTSALLDLFSPSVT 460
6_pfamImport  71 ALVCLfpPR-----------------------------NELNDHLDTMDSSLDNLQAMLSTHGFSVDTSALLDLFSPSVT 121
4_pfamImport 112 NINLL--GK-----------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTTSVQ 160
XP_008118339 377 NINLL--GK-----------------------------VELLDYLESIDCSLEDFQAMLSGRQFSIDPELLVDLFSSSVQ 425
XP_003769453 356 NINLL--GK-----------------------------VELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQ 404
XP_015212965 354 SVACL--DNspqmsevscvfp-----spsslhprtqqgNELNDHVDNIDTSLENLQTILNGQSINFDSSPLFDFFNSSMS 426
P38529       337 SVACL--DK-----------------------------NELNDHLDTIDSNLDNLQTMLSTHGFSVDTTALLDLFSPSMT 385 chicken
NP_001300665 355 SVACL--DK-----------------------------TELHDHLESIDSGLENLQQILNAQSINFDSSPLFDIFSSAAS 403 zebrafish
XP_014344337 356 SVACL--DSlvqspqmsevarlfpspstsslhcrpqqgNDLCDHLDTIDSNLDNLQTMLSAQSFSMDTSTLFDLFNPSLP 433 coelacanth
Q08DJ8       371 SVACL--DK-----------------------------TELSDHLDAMDSNLDNLQTMLTSHGFSVDTSTLLDLFSPSVt 419 domestic cattle
ELV13598     461 V-PDMSLPDLDSSLASiqellspqEPPRPLEAENSGPDSGKQLVHYTAQPLLLLDPGSVDAG---SGDLPVLFELGEGSY 536
6_pfamImport 122 V-TDMNLPDLDSSLASiqdllssqEQQKPSESEDPSADAGKQLVHYTAQPLFLVDSGSVDVGcgvGGELPIFFELGEAPS 200
4_pfamImport 161 MnPT----DHDHITNTkvetkgkeTNKNNADPAASQEMQDKQLIHYTAFPLLAFLDGNPGSA----------VESGV--F 224
XP_008118339 426 MsPTGHINSAKVETKGietvktngAQRTTQDVPNSKLKADKQLIQYTAFPLLALLDGSPGSA----------VESTN--V 493
XP_003769453 405 MnPTDYISNTKLENKGsetnknneVQPTSEDGKNSKPKSDKQLIQYTAFPLLAFLDGSPSST----------VENGS--A 472
XP_015212965 427 T-PDFNLPDLDTSLASiqdl--ltqdQKATETTEPSTDAGKQLVQYTAQPVLLVDPSNAEIT---SGELPILFALEND-- 498
P38529       386 V-TDMNLPDLDSSLASiqdllssqEQQKPSEADAAAADTGKQLVHYTAQPLFLVDSSAVDVG---SGDLPIFFELGEGSY 461 chicken
NP_001300665 404 D-VDL------DSLASiqdl--lspdPVKETESGVDTDSGKQLVQYTSQPIVLPDPLSTDSS---STDLPMLLELQDDSY 471 zebrafish
XP_014344337 434 T-SDMGLPDLDTSLDTiqdllssqE-QKPTDTDSNTADTGKQLVHYSAQPLFLLDSGSGDMG---SGDLPILFELGDAPY 508 coelacanth
Q08DJ8       420 vpdmslpdlds-slasiqellspqEPPRPLEAEKSSPDSGKQLVHYTAQPLLLLDPGSVDVG---SSDLPVLFELGEGSY 495 domestic cattle
ELV13598     537 FSEGDDYADDPTI--SLLTGSEPSKAKDPTVS 566
6_pfamImport 201 FTEGDEFLEDPTA--SLFSGTEDPKPPDPAVS 230
4_pfamImport 225 TAETPSTVEKSVEgdELLESSLDPQPTQSKLV 256
XP_008118339 494 ATEPVSSLDKPLEvdELLESSLDPQPTQSKLV 525
XP_003769453 473 TSEAASSLDKPLGvdELLDSSLDPEPTQSKLV 504
XP_015212965 499 FGTGEEG-EDPTI--SLLSNDYQQKPEDPTSS 527
P38529       462 FTDGDEYNEDPTI--SLLSGTEQPKPKDPTVS 491 chicken
NP_001300665 472 FSSEPT--EDPTI--ALL--NFQPVPEDPKLS 497 zebrafish
XP_014344337 509 FAEGDES-EDPTI--ALLSSTDESKPKDPAIS 537 coelacanth
Q08DJ8       496 FSEGDDYSDDPTI--SLLTGSEPPKAKDPTVS 525 domestic cattle
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