Conserved Protein Domain Family
PHA-1

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pfam06542: PHA-1 
Regulator protein PHA-1
This family represents the protein product of the gene pha-1 which coordinates with lin-35 Rb during animal development. The protein is expressed during embryonic development and functions in the cytoplasm. PHA-1 acts in a parallel pathway with UBC-18 to regulate the activity of a common cellular target.
Statistics
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PSSM-Id: 368965
View PSSM: pfam06542
Aligned: 9 rows
Threshold Bit Score: 446.528
Threshold Setting Gi: 121957965
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGT60115      69 VNKSFNSVILSKVRSEYVQIQVSPILKPETNGEysdneeaeDDm--nQQDRKFTINDQRVSLSTAPKFFDFLNNVARIRV 146 Caenorhabditis ...
XP_003108853  67 VSKAFNNVVLSKVRAEFVTVQVSPCHIIGTNGEyseceeheDNd--tNTDRSFTVNDRKVWFHQVPKFFEFLNSVARIRV 144 Caenorhabditis ...
Q19309        80 IKKSFNEAVLHKIRKDHREVVLHTAYHCDVADEyteymgtdYE----CRYCYIYLNYQKVTSNKMSSFFRFLKDTVAVKI 155 Caenorhabditis ...
Q7YXC4        51 VNKSFNLAAIHVIRKENRTVVFHKFNRCDRLHKis-----------pCPDCSVHLNSVKLNKKNIFQYARFLKQTMKIMV 119 Caenorhabditis ...
Q9U2D4        51 VNKAFNFGIIHSIRIEHQTVIFHKPTRCDIIRR--------------CPNCTVNLNSVELNVKNIRKYARFLKQTMKITV 116 Caenorhabditis ...
O17552        56 VNKNINIALLRRIRQEHRDVLIRGASDCRFDLE--------QDakqnCPDCSVFINPQRVTMEKLEDYFRFLKEIAGVKV 127 Caenorhabditis ...
CBI63219      39 VSRHLNLAVLYKIRKEHSEIIIHNLGHCDKHLP--------------CI-CTVFINSQDICNLKLHAYFQFLNKRVKINI 103 Caenorhabditis ...
CAP37598      97 VSKLFNHVILSKIRAAFVQVQVSPDQKLDSCGEnsdneeseEDqvasLQDKSFILNDRRVVFRHVPKFFEFLNSVARIRV 176 Caenorhabditis ...
NP_494851     67 VSRSFNNVVLSKVRAEFKMVQVCPYQQPEGADEkee---peYDesndIEDRSFMINDRRTWFSQVPRFFEFLNSVARIRV 143 Caenorhabditis ...
EGT60115     147 RDLLF--------SGFTQPDKR-VHDCILYSLMDATWFSLNSYKGAEEVC-NGCA-ACTEIAARVNIYGPIQLcTLLEPI 215 Caenorhabditis ...
XP_003108853 145 RNLLF--------SGFISPDQR-LHKCILYSLLDGNWFSLYSYKGADEVC-IGCT-ACQEIASRVRIYGPVQLcTLVEPI 213 Caenorhabditis ...
Q19309       156 VKLILepargfpfSHFCLNNDLlFHNIIMNDLIGNNYKSILHFEGMIDIClHGCF-DCMRIMLNCEVYGPAQI-NVIR-- 231 Caenorhabditis ...
Q7YXC4       120 IKIRIe------dSKRVCCMITdVHQVIHKSLIGSDYDKVEEFVGIDQISfSTCI-PCEKIAANCKVFGPVQN-DMFNAI 191 Caenorhabditis ...
Q9U2D4       117 FKIIIe------dLEFSCIDREiIHLALNDLFTDSDYERVEEFIGVDNICiAGCG-ECRKMIQNCKVYGPIQL-DIFQSV 188 Caenorhabditis ...
O17552       128 RRVGVed-----vAKICDQREI--HDRVINSLIGNDDQLVEEFFGMNDIC-SGSD-ECGIIGGRCRKYGPIQE-NIFDIT 197 Caenorhabditis ...
CBI63219     104 CKLQVq------iEHFDKVVQFqLHRLILKELIGSNEDRIREFTGMFDLSyYGWDlKAERIARHCIRFGMQEGvDLHGSQ 177 Caenorhabditis ...
CAP37598     177 RDLLF--------SGFTSPNEY-LHKCILYSLLNGNWFTLCSYKGADEIC-NGCS-ACKEIASRVKIYGPVQLcTLFEPI 245 Caenorhabditis ...
NP_494851    144 RDLLF--------SGFTSPDQR-IHECILYSLLDGNWYSLNSYKGADELC-NGCA-VCSEIASRVSIYGPVQFcTLINPI 212 Caenorhabditis ...
EGT60115     216 C-GKKHYEQLIVTEILLAEIAF-------YCVTMIGSKEEAFVRLAKVITPEISCDQLDLVFSDRCMWSKDTLAHP---- 283 Caenorhabditis ...
XP_003108853 214 R-GRKHYEQLIITEILLAEIAV-------HCITMVESKAEAFNRLTKIITPEISCDQLDLVFSDRCMWSKQTLSHP---- 281 Caenorhabditis ...
Q19309       232 RkEPKHFKELELPEVMAD---LpddppnmEFKVGIENWE-----MESIKKTKISCDKLILRLSH--------SAVPnpri 295 Caenorhabditis ...
Q7YXC4       192 LrLKHHYDVLQVKDMRLYKLMI-------------LNKE-DPTVVEDFINSNITCSKLTIFLMYMYEKEAFGYSLP---- 253 Caenorhabditis ...
Q9U2D4       189 MgQKRSFDALQITDEDLYVLLW-------------LNKQKDPKLVENFINSIITCSKFTIFLTSIFEKKELGHSLP---- 251 Caenorhabditis ...
O17552       198 LkTPHHFEHLEVSDTLLHRIVL----------SLADSSQSNLAVIDKYINSRISCDSLTLMPSILLGTRK--SWIPcql- 264 Caenorhabditis ...
CBI63219     178 L---LNFDVFEVAEPHLHGIVNadkfevrRIYTDEEDEEMVYFPINRFLKMPITCDTLTFIL-----YGKDIVSLP---- 245 Caenorhabditis ...
CAP37598     246 HeKKKHYEQLIVTEI----------------------------RLASIITSEISCDQLDLVFSDRCMWSKETLSHP---- 293 Caenorhabditis ...
NP_494851    213 L-GKKSYEQLIVTEILLAEIAL-------HCVTMVGSREEAFSRLTKMITQDVNCDQLDLVFSDRCMWSKGTLAHP---- 280 Caenorhabditis ...
EGT60115     284 -------REVIDWIVKAWKIKSINV------------RFMT------GYSSIDYKQWACKRVFTEMRFDEMfvkdhnsrp 338 Caenorhabditis ...
XP_003108853 282 -------REVIDWIVKAWSVKSINV------------RFIT------GYSSIDYNLWASKRVFTEVRFDEMlvkds--lr 334 Caenorhabditis ...
Q19309       296 wyykyitREVIDIIISNWKVKTVKLiiti----nnmeEFITip--------eQFHLFTKERLGDPISTHPI--------- 354 Caenorhabditis ...
Q7YXC4       254 -------REFLDLLIKKWNVKTVEIvprqdq-----------pipyyFHCNTDFIVP-KAKFYVDYWTQPR--------- 305 Caenorhabditis ...
Q9U2D4       252 -------RELVDMLITKWNVKTVEI------------GFKNvtn-ddFYQNTDYIDP-KAKFYVDYRTQQR--------- 301 Caenorhabditis ...
O17552       265 ----qvmRQIVELIVVKWNVKNLRI------------EFGElpeldlSSGDLDL----NQKLIG-LEFESV--------- 314 Caenorhabditis ...
CBI63219     246 -------RTITHQAVSNWNAKNVNLnfrfgahnvmaeKFHEcp--------eNFKNPVNIQFVAPWNIEPV--------- 301 Caenorhabditis ...
CAP37598     294 -------REVIDWIVKAWSVKSINV------------SFIT------GYSSIDYKLWASQRVFTEMRFDEMfveqn--ts 346 Caenorhabditis ...
NP_494851    281 -------REVIDRIVKAWRVKSINI------------RFMT------EYSSIDHEMWSNKRIFTEMRFDEMfvtdhniir 335 Caenorhabditis ...
EGT60115     339 rndRRDHFERVEVDMQAG-DEIATCFAQSMgmferSGMSATAFQNVCANVKRIFPTQDMYLILPVEL--AHVASLEFDGF 415 Caenorhabditis ...
XP_003108853 335 rqnERDNFERVEVDMQAG-DEIATCFAESMgmferSGMSATAFQNVCANVKRIFPSQDMFLILPIEL--ARVASAEFDGF 411 Caenorhabditis ...
Q19309       355 ---SKNSLEKVELDLRFGvNTLVKMFHRSA--------EILPTDNIIENVRRIFPTKNMIITLPNSF--SPLPVEHHCRF 421 Caenorhabditis ...
Q7YXC4       306 ---SKYTLDGVEIDLQLT-KVVEQQIKN----------RKSLFDNFIANARRIFPSNKITVRFSKEVcqEMMSQGNVEDF 371 Caenorhabditis ...
Q9U2D4       302 ---SMYTLDVVEINIKLT-RIMEKC-------------HGSLFNNFVPNVRTIFPSNKITLKLSKEVckVLMNPDNVEDF 364 Caenorhabditis ...
O17552       315 ---ANYSLENLDICLEFS-ELLADEMEQYLk----SPEEPSPIDGLISNVQKIFSTKFLTLELPKAY--ILMTPFNLNKF 384 Caenorhabditis ...
CBI63219     302 ---SANLLESVEIKLQYT-DDILLTIEDQL-----DYDYYSPYDNIIANVQRAFPSRNMIVKLSETN--VLIAPENMHKV 370 Caenorhabditis ...
CAP37598     347 pqnRQDNFDRVEVDMQAG-DEIATCFAESMgmferSGMSATAFQNVCANVKRIFPTQDMYLILPLEL--AHVASAEFDGF 423 Caenorhabditis ...
NP_494851    336 prhERDHFERVEVDMQAG-DEIATCFAESMgmfeqSGMSATAFQNVCANVKRIFPTQDMYLILPTEL--AHVASVEFDGF 412 Caenorhabditis ...
EGT60115     416 CEALLEFAWKDERt--aRHSRLFFRLYTfgiTEKEVMRQIEKQFKINCRPVAAMLSDPSVRRsflkwlpgttsAFDRSLL 493 Caenorhabditis ...
XP_003108853 412 CEALLEFAWKDERt--aRHSRLFFRLYTfgiTEQEVMRQIEKTFKINCRPVAAMLSDPNIRRaflkwlpgtttSFDRSLL 489 Caenorhabditis ...
Q19309       422 VMMFLRMGFPKGQ----RNFNVTWRLFI-----HEPIYGTSPGFKYRNMVIPAFN------------------YKPKPWE 474 Caenorhabditis ...
Q7YXC4       372 ISGIILMTQKDAQ----PNSHISLKLYP---------------EEVDAPLIDSFLRENFEKK-----------FDSWNLE 421 Caenorhabditis ...
Q9U2D4       365 ISGVILMAQNDDH----PNSHISLKLYP---------------QQLRFRLITSFLCDNLVKL-----------FGFWSLK 414 Caenorhabditis ...
O17552       385 IGKFMRMIESSPSsptiRNSKITVKLYP---MSSQLISRTAPVFNYRTQNVPEIL--NSGAR-----------LVSGPID 448 Caenorhabditis ...
CBI63219     371 FAKFIRLTEQNQQ----RNGSVTFKLYYe--EDDRIPIKVPHIFNSSARLV----------------------------- 415 Caenorhabditis ...
CAP37598     424 CEALLAFAWKDERt--aRHSRLFFRIYTfgiTEKEVMRQIEKPFQINCRPVIAMLSSPVVRRsflkwlpgtttLFDRSLL 501 Caenorhabditis ...
NP_494851    413 CKALLEFAWKDERt--aRHSRLFFRLYTfgiTEEQVLRQTENQFKINCRPVAAMLSDSSVRRsflqwlpgstsTFDRSLL 490 Caenorhabditis ...
EGT60115     494 SFTDVSNN------------------------------CV 503 Caenorhabditis brenneri
XP_003108853 490 SFTDVSNN------------------------------CV 499 Caenorhabditis remanei
Q19309       475 YESSLQNNhlyfektvklqdeqefsffkevkiwkgnkfCV 514 Caenorhabditis elegans
Q7YXC4       422 TVSDSSANlpae-----------------------kcyQF 438 Caenorhabditis elegans
Q9U2D4       415 SVSKISENerg------------------------ksfHF 430 Caenorhabditis elegans
O17552       449 QIQKNSKDyfhlkdivsipddrsigyrtqvhiwkgrrfCL 488 Caenorhabditis elegans
CBI63219     416 --GEQPEHcwyldei-----------------lnipkeTI 436 Caenorhabditis elegans
CAP37598     502 SFTDDSNN------------------------------Cv 511 Caenorhabditis briggsae
NP_494851    491 SFTDVWNN------------------------------CV 500 Caenorhabditis elegans
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