4BQ6


Conserved Protein Domain Family
RGM_C

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pfam06534: RGM_C 
Repulsive guidance molecule (RGM) C-terminus
This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.
Statistics
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PSSM-Id: 399501
View PSSM: pfam06534
Aligned: 39 rows
Threshold Bit Score: 193.586
Threshold Setting Gi: 1494785447
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4BQ6_D        58 CTDQKVYQAVTDD--LPAAFVDGTT-SGGDSD-AKS------------LRIVERESGH-YVEMHARYIGTTVFVRQVGRY 120
XP_002602038 251 CAREKVYQAQQNN--LPDAFADGT--RSGGPNgIRS------------LVLDVRVPGR-HVEIHIRYIDTTIVLRQIGNY 313 Florida lancelet
XP_003728654 266 CAQRKLYQATAGN--LPTTFDDGTI-TSGREEg---------------VVIIEVIPGE-HVEIHIRYIATLIVIRQVGRY 326 purple sea urchin
XP_001623735 223 CVQQKIYKAKSGA--LPAAFDDGTS-TTGTSEcS--------------VRILEVEKNS-LIHIRLCHIGTDIYVRQVSQY 284 starlet sea ane...
EKC39746     241 shdfvTYRARTNY--LPGTFENGRSdVGPDKS----------------VAIQVMEPGK-HVEIYLRFIDTTIRVRQIGRY 301 Pacific oyster
XP_002428231 189 CTQEKTYEAQSDQp-LQASFVDGTH-TSGPNQsVM-------------LKLEEIDKNHqVVEIYLKYIETTLVIRQVGKY 253 human body louse
PDM66626     298 CTVSKRYEAASETehLPTAFVDGT--THSTVDgKRA------------VEVLRQSSD--HVEIVLHHASTRLHIRRAGPY 361 Pristionchus pa...
4_pfamImport   1 CTSTLRYEANADEqgLPQGFTDGTT-FQRTDHnRNS------------VEVLSQDNS--YVEIAMHYIHSSIHIRRQGPY 65 
EFX90410     188 CAPERTYEAAVDS--VPASFVDGSQ-WGGPLPpGSSglpssafehlvpVRIVEKEPGR-HVEIHARHLGATLIVRQVGRY 263 common water flea
XP_026694295 234 CTEQKFYLANNSK--LSPSFTDGTI-SSGS------------------VSVDEVIPGR-HVEIQVRFIGTTIIIRKVGSF 291 vase tunicate
4BQ6_D       121 LTLAIRMPEDl-aMSYEE--SQ---------DLQLCVNGCPLSERIDDGqgqvsAILGHSL-----------------PR 171
XP_002602038 314 LTFAIRMPEDvinTGNVD--ED---------GLQLCVKGCPLSERIDYV-----EFLKHPPq---------------sSN 362 Florida lancelet
XP_003728654 327 ITFAVRMPEEliqYQGAE-------------DMQLCVKGCPVSEQIDYA-----TFL---------------------SQ 367 purple sea urchin
XP_001623735 285 LTFHIRMPHA---LTLEDf------------SMGLCVNGCPKQQIIDYR-----ELLSFTE-----------------RR 327 starlet sea ane...
EKC39746     302 FTFAIKMPQE---IVEQSlgDD---------TQQLCVQGCPEQEQINYK-----KYLAEKR-----------------KI 347 Pacific oyster
XP_002428231 254 LSFAARLPEE---VALMD--GE---------DLQLCTSGCPNLEQLNLA-----ADHGE--------------------- 293 human body louse
PDM66626     362 LSVAVTIPNHv-lAQEQL--PYssndralplSEQLCHAGCPLHSLVPLP-----AALANPQ-----------------AF 416 Pristionchus pa...
4_pfamImport  66 LSVSVKAPSS----VLETdsDV---------SNEMCWSGCSRFSVIAQE-----SVFRKPE-----------------KF 110
EFX90410     264 LTFAAKLPRE---IALQGagRE---------GLQLCVKGCPASERIDVG-----TVLLGSGhgrhpsmpssgrfyrsqTS 326 common water flea
XP_026694295 292 LTFAIRMPHEf-iEGLDP-------------SRQLCVQGCPSRHRIDLK-----ASNKGHGntllpgtk-gsrrnaaiPP 351 vase tunicate
4BQ6_D       172 TSLVQAWPGYTLETANTQCHEKm--------PVKDIYFQSCVFDLLTTGD---ANFTAAAHSALEDVEALHP 232
XP_002602038 363 TVLHRSEVAMPKDLAIAKCRQS---------NVTDFYLDSCVFDLMTTGD---ANFTLAAKSALEDVNRLHP 422 Florida lancelet
XP_003728654 368 TTRADRNYKELRVDAIAKCRKA---------KIYDEYLDSCVFDLLTTGD---ANFTQAAKSALTDVNRLHP 427 purple sea urchin
XP_001623735 328 LAKVLPRKKITRREAKKKCQDS---------NVTGFYLDSCMFDLLTTGD---SNFTLAAKSALDDAFVMDP 387 starlet sea anemone
EKC39746     348 MDLNQGDIAMTSERASELCRQS---------QVVDFYFDSCVFDLMTTGD---ENFTIAAHQLLEDLTELSP 407 Pacific oyster
XP_002428231 294 --------AMSWEEALNVCQDSnglsneinnKLTDHYLDWCVFDVMTTGEvasSDFTAAAHSAQADVLRFDP 357 human body louse
PDM66626     417 SECHGTPVALPLKLATERCKSF---------NVTDDFFDACVFDLIATGD---ELLGKMSREAQRDLETQLt 476 Pristionchus pacificus
4_pfamImport 111 VACYARQLHVPKKVAEERCSSV---------GTTDAFFAACVFDLMLTGD---DYLVHLARNVQSDFRRLAP 170
EFX90410     327 ESPSALVKGMTRDAALALCREY---------NLTDYYLDSCMFDLMTTGD---PSFSLAASRAQADYFSLLP 386 common water flea
XP_026694295 352 VPKAEQKKIFTEEEARQKCQQImla---etsPIDEvgnkdgqtdsdevnqlshaqssaafsslvpsedqghh 420 vase tunicate
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