4BQ6


Conserved Protein Domain Family
RGM_C
?
pfam06534: RGM_C 
Click on image for an interactive view with Cn3D
Repulsive guidance molecule (RGM) C-terminus
This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.
Links
?
Statistics
?
PSSM-Id: 428993
Aligned: 34 rows
Threshold Bit Score: -1
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
4BQ6_D        58 CTDQKVYQAVTDD--LPAAFVDGTT-SGGDSDak-------------sLRIVERESGH-YVEMHARYIGTTVFVRQVGRY 120 human
EKC39746     241 SHDFVTYRARTNY--LPGTFENGRSdVGPDKS----------------VAIQVMEPGK-HVEIYLRFIDTTIRVRQIGRY 301 Pacific oyster
EFX90410     188 CAPERTYEAAVDS--VPASFVDGSQ-WGGPLPpgssglpssafehlvpVRIVEKEPGR-HVEIHARHLGATLIVRQVGRY 263 common water flea
XP_002428231 189 CTQEKTYEAQSDQp-LQASFVDGTH-TSGPNQsv-------------mLKLEEIDKNHqVVEIYLKYIETTLVIRQVGKY 253 human body louse
PDM66626     298 CTVSKRYEAASETehLPTAFVDGT--THSTVDgk------------raVEVLRQSSD--HVEIVLHHASTRLHIRRAGPY 361 Pristionchus pa...
3_pfamImport   1 CTSTLRYEANADEqgLPQGFTDGTT-FQRTDHnr------------nsVEVLSQDNS--YVEIAMHYIHSSIHIRRQGPY 65 
4_pfamImport   1 CTEQKFYLANNSK--LSPSFTDGTI-SSGS------------------VSVDEVIPGR-HVEIQVRFIGTTIIIRKVGSF 58 
XP_001623735 223 CVQQKIYKAKSGA--LPAAFDDGTS-TTGTSEc--------------sVRILEVEKNS-LIHIRLCHIGTDIYVRQVSQY 284 starlet sea ane...
XP_002602038 251 CAREKVYQAQQNN--LPDAFADGT--RSGGPNgi------------rsLVLDVRVPGR-HVEIHIRYIDTTIVLRQIGNY 313 Florida lancelet
XP_781467    265 CAQRKLYQATAGN--LPTTFDDGTI-TSGREEg---------------VVIIEVIPGE-HVEIHIRYIATLIVIRQVGRY 325 purple sea urchin
EKC39746     241 SHDFVTYRARTNY--LPGTFENGRSdVGPDKS----------------VAIQVMEPGK-HVEIYLRFIDTTIRVRQIGRY 301 Pacific oyster
EFX90410     188 CAPERTYEAAVDS--VPASFVDGSQ-WGGPLPpgssglpssafehlvpVRIVEKEPGR-HVEIHARHLGATLIVRQVGRY 263 common water flea
XP_002428231 189 CTQEKTYEAQSDQp-LQASFVDGTH-TSGPNQsv-------------mLKLEEIDKNHqVVEIYLKYIETTLVIRQVGKY 253 human body louse
PDM66626     298 CTVSKRYEAASETehLPTAFVDGT--THSTVDgk------------raVEVLRQSSD--HVEIVLHHASTRLHIRRAGPY 361 Pristionchus pa...
3_pfamImport   1 CTSTLRYEANADEqgLPQGFTDGTT-FQRTDHnr------------nsVEVLSQDNS--YVEIAMHYIHSSIHIRRQGPY 65 
4_pfamImport   1 CTEQKFYLANNSK--LSPSFTDGTI-SSGS------------------VSVDEVIPGR-HVEIQVRFIGTTIIIRKVGSF 58 
XP_001623735 223 CVQQKIYKAKSGA--LPAAFDDGTS-TTGTSEc--------------sVRILEVEKNS-LIHIRLCHIGTDIYVRQVSQY 284 starlet sea ane...
XP_002602038 251 CAREKVYQAQQNN--LPDAFADGT--RSGGPNgi------------rsLVLDVRVPGR-HVEIHIRYIDTTIVLRQIGNY 313 Florida lancelet
XP_781467    265 CAQRKLYQATAGN--LPTTFDDGTI-TSGREEg---------------VVIIEVIPGE-HVEIHIRYIATLIVIRQVGRY 325 purple sea urchin

4BQ6_D       121 LTLAIRMPEDl-aMSYEE--SQ---------DLQLCVNGCPLSERIDDGqgqvsAILGHSL-----------------PR 171 human
EKC39746     302 FTFAIKMPQE---IVEQSlgDD---------TQQLCVQGCPEQEQINYK-----KYLAEKR-----------------KI 347 Pacific oyster
EFX90410     264 LTFAAKLPRE---IALQGagRE---------GLQLCVKGCPASERIDVG-----TVLLGSGhgrhpsmpssgrfyrsqTS 326 common water flea
XP_002428231 254 LSFAARLPEE---VALMD--GE---------DLQLCTSGCPNLEQLNLA-----ADHGE--------------------- 293 human body louse
PDM66626     362 LSVAVTIPNHv-lAQEQL--PYssndralplSEQLCHAGCPLHSLVPLP-----AALANPQ-----------------AF 416 Pristionchus pa...
3_pfamImport  66 LSVSVKAPSS----VLETdsDV---------SNEMCWSGCSRFSVIAQE-----SVFRKPE-----------------KF 110
4_pfamImport  59 LTFAIRMPHEf-iEGLDP-------------SRQLCVQGCPSRHRIDLK-----ASNKGHGntllpgtk-gsrrnaaiPP 118
XP_001623735 285 LTFHIRMPHA---LTLEDf------------SMGLCVNGCPKQQIIDYR-----ELLSFTE-----------------RR 327 starlet sea ane...
XP_002602038 314 LTFAIRMPEDvinTGNVD--ED---------GLQLCVKGCPLSERIDYV-----EFLKHPPq---------------sSN 362 Florida lancelet
XP_781467    326 ITFAVRMPEEliqYQGAE-------------DMQLCVKGCPVSEQIDYA-----TFL---------------------SQ 366 purple sea urchin
EKC39746     302 FTFAIKMPQE---IVEQSlgDD---------TQQLCVQGCPEQEQINYK-----KYLAEKR-----------------KI 347 Pacific oyster
EFX90410     264 LTFAAKLPRE---IALQGagRE---------GLQLCVKGCPASERIDVG-----TVLLGSGhgrhpsmpssgrfyrsqTS 326 common water flea
XP_002428231 254 LSFAARLPEE---VALMD--GE---------DLQLCTSGCPNLEQLNLA-----ADHGE--------------------- 293 human body louse
PDM66626     362 LSVAVTIPNHv-lAQEQL--PYssndralplSEQLCHAGCPLHSLVPLP-----AALANPQ-----------------AF 416 Pristionchus pa...
3_pfamImport  66 LSVSVKAPSS----VLETdsDV---------SNEMCWSGCSRFSVIAQE-----SVFRKPE-----------------KF 110
4_pfamImport  59 LTFAIRMPHEf-iEGLDP-------------SRQLCVQGCPSRHRIDLK-----ASNKGHGntllpgtk-gsrrnaaiPP 118
XP_001623735 285 LTFHIRMPHA---LTLEDf------------SMGLCVNGCPKQQIIDYR-----ELLSFTE-----------------RR 327 starlet sea ane...
XP_002602038 314 LTFAIRMPEDvinTGNVD--ED---------GLQLCVKGCPLSERIDYV-----EFLKHPPq---------------sSN 362 Florida lancelet
XP_781467    326 ITFAVRMPEEliqYQGAE-------------DMQLCVKGCPVSEQIDYA-----TFL---------------------SQ 366 purple sea urchin

4BQ6_D       172 TSLVQAWPGYTLETANTQCHEKm--------PVKDIYFQSCVFDLLTTGD---ANFTAAAHSALEDVEALHP 232 human
EKC39746     348 MDLNQGDIAMTSERASELCRQS---------QVVDFYFDSCVFDLMTTGD---ENFTIAAHQLLEDLTELSP 407 Pacific oyster
EFX90410     327 ESPSALVKGMTRDAALALCREY---------NLTDYYLDSCMFDLMTTGD---PSFSLAASRAQADYFSLLP 386 common water flea
XP_002428231 294 --------AMSWEEALNVCQDSnglsneinnKLTDHYLDWCVFDVMTTGEvasSDFTAAAHSAQADVLRFDP 357 human body louse
PDM66626     417 SECHGTPVALPLKLATERCKSF---------NVTDDFFDACVFDLIATGD---ELLGKMSREAQRDLETQLT 476 Pristionchus pacificus
3_pfamImport 111 VACYARQLHVPKKVAEERCSSV---------GTTDAFFAACVFDLMLTGD---DYLVHLARNVQSDFRRLAP 170
4_pfamImport 119 VPKAEQKKIFTEEEARQKCQQImla---etsPIDEFYFDSCVFDLLTTGD---VNFTLSARAALEDVRRTHT 184
XP_001623735 328 LAKVLPRKKITRREAKKKCQDS---------NVTGFYLDSCMFDLLTTGD---SNFTLAAKSALDDAFVMDP 387 starlet sea anemone
XP_002602038 363 TVLHRSEVAMPKDLAIAKCRQS---------NVTDFYLDSCVFDLMTTGD---ANFTLAAKSALEDVNRLHP 422 Florida lancelet
XP_781467    367 TTRADRNYKELRVDAIAKCRKA---------KIYDEYLDSCVFDLLTTGD---ANFTQAAKSALTDVNRLHP 426 purple sea urchin
EKC39746     348 MDLNQGDIAMTSERASELCRQS---------QVVDFYFDSCVFDLMTTGD---ENFTIAAHQLLEDLTELSP 407 Pacific oyster
EFX90410     327 ESPSALVKGMTRDAALALCREY---------NLTDYYLDSCMFDLMTTGD---PSFSLAASRAQADYFSLLP 386 common water flea
XP_002428231 294 --------AMSWEEALNVCQDSnglsneinnKLTDHYLDWCVFDVMTTGEvasSDFTAAAHSAQADVLRFDP 357 human body louse
PDM66626     417 SECHGTPVALPLKLATERCKSF---------NVTDDFFDACVFDLIATGD---ELLGKMSREAQRDLETQLT 476 Pristionchus pacificus
3_pfamImport 111 VACYARQLHVPKKVAEERCSSV---------GTTDAFFAACVFDLMLTGD---DYLVHLARNVQSDFRRLAP 170
4_pfamImport 119 VPKAEQKKIFTEEEARQKCQQImla---etsPIDEFYFDSCVFDLLTTGD---VNFTLSARAALEDVRRTHT 184
XP_001623735 328 LAKVLPRKKITRREAKKKCQDS---------NVTGFYLDSCMFDLLTTGD---SNFTLAAKSALDDAFVMDP 387 starlet sea anemone
XP_002602038 363 TVLHRSEVAMPKDLAIAKCRQS---------NVTDFYLDSCVFDLMTTGD---ANFTLAAKSALEDVNRLHP 422 Florida lancelet
XP_781467    367 TTRADRNYKELRVDAIAKCRKA---------KIYDEYLDSCVFDLLTTGD---ANFTQAAKSALTDVNRLHP 426 purple sea urchin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap