pfam06534: RGM_C (This model is not part of the current CDD release)
Repulsive guidance molecule (RGM) C-terminus
This family represents the C-terminal region of repulsive guidance molecule (RGM), although in some sequences it represents the full protein. RGM is a GPI-linked axon guidance molecule of the retinotectal system, and controls cell motility, adhesion, immune cell regulation and systemic iron metabolism. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum. This domain is responsible for neogenin (NEO1) binding.
Jiyao W et al.(2023). "The conserved domain database in 2023.",