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Negative regulator of sigma F This family includes CC3252 (NrsF- Negative regulator of sigma F) from Caulobacter crescentus, which is proposed to be an anti-sigma factor. In particular, overexpression of NrsF prevents the induction of the sigF regulon after dichromate stress. Family members also include the anti-sigma factor OsrA (blr3039) from Bradyrhizobium japonicum, which is involved in sensing reactive oxygen species. There is evidence that OsrA binds an ECF-type sigma factor (EcfF) in vivo. Furthermore, the conserved cysteine residues 129 and 179 of OsrA are shown to be required for normal function. Family members have 6 predicted transmembrane regions. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",