4A90


Conserved Protein Domain Family
SAP18

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pfam06487: SAP18 
Sin3 associated polypeptide p18 (SAP18)
This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.
Statistics
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PSSM-Id: 399479
View PSSM: pfam06487
Aligned: 116 rows
Threshold Bit Score: 86.0589
Threshold Setting Gi: 388580114
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A90_A        20 IDREKTCPLLLRVF-TtNNGRHHRMDEFS---RGnVPs----SELQIYTWMDATLKELTSLVKEV------YPEARKK-- 83 
EGF77463      94 LDRSMICPFLIRVF-V-NSERVHDDADFG---KGkLPt----NSVNIYCWKDSTIREVAALLGQAma---sTADASA--- 158 Batrachochytriu...
EIM20431       4 seldiHCPRLIRVF-V-RTTQPYDAYSFD----KgLPs---kDEYDILAGPNTTIRELLLLLQKSlp---eNLRHPRS-- 69  Wallemia mellic...
Q5KAN1        33 ppkgPRTPHLIRMF-V-TKGRHAPLADFD---AGlFPt---rDEFQVYAWQTSTPSELIKLLYPSfp---aPYRSPQT-- 99  Cryptococcus ne...
KDE08646      58 VKRSTTVPSLLRVFvS-RTPQHHDEALFSspdGTgPArsilqDEYQLYVWRDSTLKELVHALASSft---lPTTPPNI-- 131 Microbotryum ly...
CEL63934      10 VDRTKKPPFLLRTF-V-RSGGFHPETAFD---NGrVPt---lDEHAVHVWSDSTLIDIVRALRAQ-------TPSPSLpa 74  Rhizoctonia sol...
XP_007392463  12 VDREKTAPFLIRTF-I-KVGTFHRLQQFE---DAaAPt---aDEQQLYTWKDATLREVLTTLRSIapatpeYRHPLA--- 80  Phanerochaete c...
EMD40331      12 VDREKTAPFLIRTF-I-KIGSFHRLTQFD---DGsVPi---aDEQQIFTWKDATLREVLTTLRATapaspeYRHPLA--- 80  Gelatoporia sub...
EGO02292      13 VSREKTAPFLIRAF-V-KTGGFHRLALFE---EGsLPt---tDEQQIFTWKDATLREVLTTLRNTapptpeFRHPLA--- 81  Serpula lacryma...
EEB94277      21 VSREKTAPFLIRTF-V-KIGGFHRLSLFE---DGtLPt---tDEQQLFTWKDATLREVLTTLRNTaphvpeYRHPLA--- 89  Moniliophthora ...
4A90_A        84 ------GTHFNFAIVFMDlKr--PGYRVKEIG-----------STMSGRKGt---DDs---------------------- 119
EGF77463     159 --------KLIFRTVNRT-EhfrGIFKPRTLG-----------SIFNFKHTld--------------------------- 191 Batrachochytriu...
EIM20431      70 --------IYGVHSIYVD-Mks-mYHKERDLGr---------ySLSVKNYSdkydDQ----------------------- 107 Wallemia mellic...
Q5KAN1       100 --------RFHFRHVYVD-AsprGLYRFKDLT-----------SFIGRDLQsgsnDDsmdldedrel------------- 146 Cryptococcus ne...
KDE08646     132 --------RYSFKLVYYD-Aqs-sRHRSKPIGllt------nrDIFHSTKSttgtAPg---------------------- 173 Microbotryum ly...
CEL63934      75 gafrnpSTRYSFRVVYYD-R---GNVASRDLGqvgprelndisGLYPSSGGqtptPPteptdlpadsamdadddsprkdr 150 Rhizoctonia sol...
XP_007392463  81 --------RYTFRAIYAD-SasrGRIAQKDLG-----------TVYSRDILgepgTLqapaprllad------------- 127 Phanerochaete c...
EMD40331      81 --------RYSFRALYAD-SaarGRVAQKDLG-----------LVYSRDILgepgSLaspaprllsd------------- 127 Gelatoporia sub...
EGO02292      82 --------RYSFRAIYAD-SanrGRFAQKELG-----------IVYSRDILgepgTIdspaprlledtdg---------- 131 Serpula lacryma...
EEB94277      90 --------RFSFRTVYAD-StnkGRFASKELG-----------MVYSRDILgepgSTtstaprlledvdn---------- 139 Moniliophthora ...
4A90_A       120 ----------------------MTLQSQKFQIgDYLDI 135
EGF77463     192 --------------------eaRTLDEVRFVPgDFIDV 209 Batrachochytrium dendrobatidis JAM81
EIM20431     108 ----------------------STLDEARIYPgDYLSV 123 Wallemia mellicola CBS 633.66
Q5KAN1       147 -------------grrgrkieeKSLDDYGFVTgDFLSV 171 Cryptococcus neoformans
KDE08646     174 ---------------------dKTLHQTSWVVgDYLSI 190 Microbotryum lychnidis-dioicae p1A1 Lamole
CEL63934     151 ddedvltagattrggsrsksgsRTLDELRVKPgDWLSV 188 Rhizoctonia solani AG-1 IB
XP_007392463 128 -------------tdappgdeeRTLDELRFVPgDYMCV 152 Phanerochaete carnosa HHB-10118-sp
EMD40331     128 -------------adapppadeRTLDELRFVPgDYLCV 152 Gelatoporia subvermispora B
EGO02292     132 ----------earepserereaRTLEELRFVPgDYLCI 159 Serpula lacrymans var. lacrymans S7.3
EEB94277     140 ----------esrelterereeRTLDELRFVPgDYLLV 167 Moniliophthora perniciosa FA553
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