4A90


Conserved Protein Domain Family
SAP18

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pfam06487: SAP18 
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Sin3 associated polypeptide p18 (SAP18)
This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.
Statistics
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PSSM-Id: 428974
Aligned: 113 rows
Threshold Bit Score: 81.4318
Threshold Setting Gi: 388851930
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A90_A                20 IDREKTCPLLLRVF-TtNNGRHHRMD-EFS-RGnVPs-SELQIYTWMDATLKELTSLVKEV------YPEARKKgtHFNF 89   house ...
EGO02292              13 VSREKTAPFLIRAF-V-KTGGFHRLA-LFE-EGsLPttDEQQIFTWKDATLREVLTTLRNTapptpeFRHPLA---RYSF 85   Serpul...
EEB94277              21 VSREKTAPFLIRTF-V-KIGGFHRLS-LFE-DGtLPttDEQQLFTWKDATLREVLTTLRNTaphvpeYRHPLA---RFSF 93   Monili...
WGS:AACS:CC1G_07936   14 VARDKTAPFLIRTF-V-KIGGFHRLT-LFE-DGtLPttDEHQIFTWRDATLKEILTTLRNTsphvaeFKHPLA---RFSF 86   Coprin...
EIM20431               4 seldiHCPRLIRVF-V-RTTQPYDAY-SFD--KgLPskDEYDILAGPNTTIRELLLLLQKSlp---eNLRHPRS--IYGV 73   Wallem...
Q5KAN1                33 ppkgPRTPHLIRMF-V-TKGRHAPLA-DFD-AGlFPtrDEFQVYAWQTSTPSELIKLLYPSfp---aPYRSPQT--RFHF 103  Crypto...
EGF77463              94 LDRSMICPFLIRVF-V-NSERVHDDA-DFG-KGkLPt-NSVNIYCWKDSTIREVAALLGQAma---sTADASA---KLIF 162  Batrac...
XP_001025101          12 VNRNEVCPFLIRVFpV-ENNSL-DLK-YFEdGTaLKkyNSINVYAWKDDTLRNIIELSRSQik---iPSDVKNL--RFYL 83   Tetrah...
XP_007411828          12 VDREKTCPFLLRVF-V-KPGSHHDIDrDFQlPDkLPipNESQLYAWKDTTLRDICLQLLETnp---tIKLSTNP--KFSI 84   Melamp...
OAV97091              11 VDREKTCPFLLRVF-V-KPGSHHDPErDYQvPDrLPvsNECQLYAWKDTTLRDICLQLLDSnp---sIKSNLPL--KFSI 83   Puccin...
4A90_A                90 AIVFMDlKr------------PGYRVKEIG--STMSGRKGt---DDs--------------------------------- 119  house ...
EGO02292              86 RAIYAD-San----------rGRFAQKELG--IVYSRDILgepgTIdspaprlledtdg---------earepsererea 143  Serpul...
EEB94277              94 RTVYAD-Stn----------kGRFASKELG--MVYSRDILgepgSTtstaprlledvdn---------esreltereree 151  Monili...
WGS:AACS:CC1G_07936   87 KAVYAD-Sas----------kGRFTQKDLG--MVYSRDILgepgSHgvtaprllledeeggggaaanrdsehpvpreree 153  Coprin...
EIM20431              74 HSIYVD-Mks-----------mYHKERDLGrySLSVKNYSdkydDQ---------------------------------- 107  Wallem...
Q5KAN1               104 RHVYVD-Asp----------rGLYRFKDLT--SFIGRDLQsgsnDDsmdldedrel---------------grrgrkiee 155  Crypto...
EGF77463             163 RTVNRT-Ehf----------rGIFKPRTLG--SIFNFKHTld------------------------------------ea 193  Batrac...
XP_001025101          84 NSIYQD-Pkn-----------nKWVTKKLG--MIYDQDLSskdrKDe--------------------------------q 117  Tetrah...
XP_007411828          85 RLIFLD-Tprein----stnfARYKSQELG--IIFSRDLSrdqsSGsipg---------------------------pst 130  Melamp...
OAV97091              84 RLVFLD-TprdlstsshnsplPRYKSQDLG--SIFCRDLTrpvtAApa-------------------------------n 129  Puccin...
4A90_A               120 MTLQSQKFQIgDYLDI 135  house mouse
EGO02292             144 RTLEELRFVPgDYLCI 159  Serpula lacrymans var. lacrymans S7.3
EEB94277             152 RTLDELRFVPgDYLLV 167  Moniliophthora perniciosa FA553
WGS:AACS:CC1G_07936  154 RTLDDLRFVPgDYIMV 169  Coprinopsis cinerea okayama7#130
EIM20431             108 STLDEARIYPgDYLSV 123  Wallemia mellicola CBS 633.66
Q5KAN1               156 KSLDDYGFVTgDFLSV 171  Cryptococcus neoformans
EGF77463             194 RTLDEVRFVPgDFIDV 209  Batrachochytrium dendrobatidis JAM81
XP_001025101         118 QTLANFQFMIgDYIEI 133  Tetrahymena thermophila SB210
XP_007411828         131 RTLQEVQFMVgDYLDI 146  Melampsora larici-populina 98AG31
OAV97091             130 KSLHDVRFCVgDFVDI 145  Puccinia triticina 1-1 BBBD Race 1
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