Conserved Protein Domain Family
Ten_N

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pfam06484: Ten_N (This model is not part of the current CDD release)
Teneurin Intracellular Region
This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here.
Statistics
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PSSM-Id: 517300
Aligned: 7 rows
Threshold Bit Score: 519.147
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_069046159   11 SLT-ARRDAERRYTSSSADSEE--SKLH-PKSYSSSETLKAFDQD-SRLVYGNRVKDMVHQEADEFGRQGTDFSLRELGF 85  
Q9WTS5         10 SLTrGRCGKECRYTSSSLDSED--CRVPtQKSYSSSETLKAYDHD-SRMHYGNRVTDLVHRESDEFSRQGTNFTLAELGI 86   house mouse
XP_016153468   11 SLTkSRRDKERRYTNSSAENEE--CRVPtQKSYSSSETLKAFDHDsSRLLYGNRVKDLVHREADEYTRQGQNFTLRQLGV 88  
3_pfamImport    1 RGGkKDKDRERRYTASSSDRDEgaCRVPtQKSYSSSETLQAFDHDpSRMLFGGRVKEMVHKETAEYTRPGQTFSLRQLGI 80  
2_pfamImport    1 IYCeRDVDQEPRYTASTADREEgtCRVPtQKSYSSSETLQAFDHDpSRMLFGGRVKEMVHKESAEYSRPGQTFSLRQFGI 80  
XP_029699366   11 SLT-ARQDTERRYTSSSADSED--GKPN-PKSYSSSETLKAFDHD-SRMAYGSRVKEMVHHEVDEFSRQGVDFSLRNLGF 85   torafugu
XP_040503293   11 SLT-RRRDTERRYTSSSAESED--SKAP-QKSYSSSETLKAYDQD-SRLTYSNRVKDMVHQEADEFCRAGANFSLRELGL 85   chicken
XP_069046159   86 GEGMPlHGTSYRTEIGLPHRGFSISAGSDADTETDGIMSPEHAVRLWGRn-TKSGRSSCLSSRANSNLTLTDTEHENTEN 164 
Q9WTS5         87 CEPSP-HRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRg-IKSRRSSGLSSRENSALTLTDSDNENKSD 164  house mouse
XP_016153468   89 CEPAArRGLAFCAEMGLPHRGYSISAGSDADTENEGVMSPEHAMRLWGRg-VKSGRSSCLSSRSNSALTLTDTEHENKSD 167 
3_pfamImport   81 CEPPArRGLALCPETGLSHPLSSYSRGPVA-TENHEPVSPERTITLWGTg-AKSGQNSCLSSRSNSALTLTDTEMDNKSD 158 
2_pfamImport   81 CEPSArRGLAPCPETGPSHPLSSYCRGPAA-AENHEPASPERTMTLWG---AKSGQNSCLSSRSNSALTLTDTEMDNKSD 156 
XP_029699366   86 GEALPsHVATYRTEMGLPHRDYSVSVGSDPDTETDGIMSPEHAVRLWGRsnTKSGRSSCLSSRANSNLTLTDTEHENTEN 165  torafugu
XP_040503293   86 EDVTPtHGTLYRTDIGLPHCGYSISAGSDADTEADVVMSPEHPVRLWGRn-TKSGRSSCLSSRANSNLTLTDTEHENTET 164  chicken
XP_069046159  165 ---GPPLHCSSAS---------STpveqSPSPPpsleaNESQRRLLGNSVVQPTPDSDSEEEFAPNSFLVKTGSGNLCAP 232 
Q9WTS5        165 ddnGRPIPPTSSSsllpsaqlpSS----HNPPP-----VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQAS 235  house mouse
XP_016153468  168 senGPPMPSSSSSp--------SVtehlHSPPPsp-nlHDNQRWLLSNNASQPVQDSDTDEDYTAGSYLVQTGDNPVSVP 238 
3_pfamImport  159 nemGDYSLLSDLLtc-----------hkCTVPPtn--rKEKIMCTFPREKSHGYLNSYADACFSLASSPGDHLSSQQAPP 225 
2_pfamImport  157 netGRKIKPSTCQql------iTAesapVSQPp----pTKNQEPDMARNSWHKELNVNPSDFFSPQAKLLRIFQSSASIC 226 
XP_029699366  166 g---PPLHCSSAS---------SSpveqLPYPPpsiaaNESQRGLLGNSAAQPAQDSDSEDEFGPNSFLVKTGSGNLYTP 233  torafugu
XP_040503293  165 -----------------------------DHPP----------------------------------------------- 168  chicken
XP_069046159  233 ttaaEDQSSSFQNHSRLRTpp---lPVSHSHTP-NQHHAASANSLNRGNYTPRSNPSPAPtdHSLPPEGP--TQDSGSAQ 306 
Q9WTS5        236 ----SSGPPNHHSQSTLRP------PLPPPHNHtLSHHHSSANSLNRNSLTNRRSQIHAP--APAPNDLAt-TPESVQLQ 302  house mouse
XP_016153468  239 g---HEQPPNNQGQSTLQ-------PLPPSHKQhSAQHHPSITSLNRNSLTNRRNQSPAPp-AALPAELQt-TPESVQLQ 306 
3_pfamImport  226 pl----------------------pPAPPPHKQ-----HPSITSLSRSSLANQRSPSPPPt-AGLAADLQs-TAECVQLQ 276 
2_pfamImport  227 -----------------KPgppplpPAPPPHRQ-----HPSITSLSRSSLANQRSPSPPPt-AGLAADLQs-TAECVQLQ 282 
XP_029699366  234 ataaAEEGA-FQNHSRLRTpp---lPLSHSHSPsHQHHAASINSLNRSNYTQRSNPSPAPtdSSVPPEGPa-NQDSVSVQ 308  torafugu
XP_040503293  169 ---------NLQNHSRLRTpp---pPISHAHTP-NQHHAASINSLNRGNFTPRSNPSPAPtdHSLSGEQPasTQEPAHAQ 235  chicken
XP_069046159  307 DNWLLNSNIPLETRniakqtfletlqdnliemdilasahrdgaysegHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPP 385 
Q9WTS5        303 DSWVLNSNVPLETR---------------------------------HFLFKTSsGSTPLFSSSSPGYPLTSGTVYTPPP 349  house mouse
XP_016153468  307 DSWVLGSNAPLESRelesqavlanghdnli--emdvfsptyhdssygHFLFKTGtGTTPLFSTATPGYTMASGSVYSPPT 384 
3_pfamImport  277 DSWVLGSNVALESR---------------------------------HFLFKTGtGTTPFFGAAAPGYTMATGTVYSTPA 323 
2_pfamImport  283 DSWVLGSNVALESR---------------------------------HFLFKTGtGSTPFFGAAAPGYTMATGTVYSTPA 329 
XP_029699366  309 DNWLLNSNIPLETR---------------------------------QFLFKPG-GTSPMYCTTSPGYPLTSSTVYSPPP 354  torafugu
XP_040503293  236 DNWLLNSNIPLETR---------------------------------HFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPP 281  chicken
XP_069046159  386 RPLPRSTFSRPAFNLKKPYKYCNWK 410 
Q9WTS5        350 RLLPRNTFSRKAFKLKKPSKYCSWK 374  house mouse
XP_016153468  385 RPLPRNTLSRSAFKFKKSSKYCSWK 409 
3_pfamImport  324 RPLPRNSLSRGAFKFKKSPKHCSWK 348 
2_pfamImport  330 RPLPRNTLSRGAFKFKKSPKYCSWK 354 
XP_029699366  355 RPLPRNTFSRPAFSLKKPYKHCNWK 379  torafugu
XP_040503293  282 RPLPRSTFSRPAFNLKKPYKYCNWK 306  chicken
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