1BNL,1DY2


Conserved Protein Domain Family
Endostatin
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pfam06482: Endostatin 
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Collagenase NC10 and Endostatin
NC10 stands for Non-helical region 10 and is taken from COL15A1. A mutation in this region in COL18A1 is associated with an increased risk of prostate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumor suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to.
Links
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Statistics
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PSSM-Id: 428970
Aligned: 15 rows
Threshold Bit Score: -1
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BNL_A         10 LHLVALNAPLSGGMRgirgADFQCFQQARAVGLAGTFRAFLSSRLQDLYSIVRRADRAAVPIVNLKDELLFPS------- 82   human
9_pfamImport    1 LHLIALNGPQTGAMQgirgADFLCFTQAQAIGMKGTFRAFLSSRLQDLHSIVRRTDRERIPIVNLKDEVLFDS------- 73  
7_pfamImport    1 LRLIALNTPQSGNMKgirgPDYLCFEQARAAGLRGTFRAFLSSKVQDLHTIVRHSDREKPPIVNLKNQVLFDS------- 73  
4_pfamImport    1 LHIIALNAPQTGNMRgirgADFLCFQQARAVGLKGTFRAFLSSKLQDLYTIVRRSDRDSTPIVNLKDQVLFSS------- 73  
5_pfamImport    1 LHLVALNSPLKGDMRgirgADFQCYQQARSMGLTTTYRAFLSSHLQDLATIVRKADRTDMPVVNLRGEVLFSS------- 73  
3_pfamImport    1 LHLVALNLPFSGDMR----ADFHCFQQAQQAGLMTTYRAFLSSHLQDLVTVVRKTDRYNLPIVNLKGETLFNN------- 69  
8_pfamImport    1 LHLIALNTPLTGDMRgirgVDFQCFQQARSVGLMGTFRAFLSSRLQDLYSIVRRADRTNVPIVNLRDRLLSPSvpvgshm 80  
XP_008108790 1208 LHLIALNTPLSGSMRgirgADFQCFQQAREVGLTGTFRAFLSSRLQDLYSIVRRADRSTVPIVNLRDEVLFNN------- 1280 green anole
AAH63929     1127 LHLVALNTPLSGSMKsirgVDFQCFEQARKAGLHGTFRAFLSSRLQDLYSIVRRADRQSVQIVNLRDEVLFDN------- 1199 tropical claw...
XP_023185092 1461 LHLIALNSPQKGGMRgisgADFLCFSQAQAIGMKGTFRAFLSSKLEDLNSIVYSSNRENVPIVNLKDEVLFDN------- 1533 southern plat...
9_pfamImport    1 LHLIALNGPQTGAMQgirgADFLCFTQAQAIGMKGTFRAFLSSRLQDLHSIVRRTDRERIPIVNLKDEVLFDS------- 73  
7_pfamImport    1 LRLIALNTPQSGNMKgirgPDYLCFEQARAAGLRGTFRAFLSSKVQDLHTIVRHSDREKPPIVNLKNQVLFDS------- 73  
4_pfamImport    1 LHIIALNAPQTGNMRgirgADFLCFQQARAVGLKGTFRAFLSSKLQDLYTIVRRSDRDSTPIVNLKDQVLFSS------- 73  
5_pfamImport    1 LHLVALNSPLKGDMRgirgADFQCYQQARSMGLTTTYRAFLSSHLQDLATIVRKADRTDMPVVNLRGEVLFSS------- 73  
3_pfamImport    1 LHLVALNLPFSGDMR----ADFHCFQQAQQAGLMTTYRAFLSSHLQDLVTVVRKTDRYNLPIVNLKGETLFNN------- 69  
8_pfamImport    1 LHLIALNTPLTGDMRgirgVDFQCFQQARSVGLMGTFRAFLSSRLQDLYSIVRRADRTNVPIVNLRDRLLSPSvpvgshm 80  
XP_008108790 1208 LHLIALNTPLSGSMRgirgADFQCFQQAREVGLTGTFRAFLSSRLQDLYSIVRRADRSTVPIVNLRDEVLFNN------- 1280 green anole
AAH63929     1127 LHLVALNTPLSGSMKsirgVDFQCFEQARKAGLHGTFRAFLSSRLQDLYSIVRRADRQSVQIVNLRDEVLFDN------- 1199 tropical claw...
XP_023185092 1461 LHLIALNSPQKGGMRgisgADFLCFSQAQAIGMKGTFRAFLSSKLEDLNSIVYSSNRENVPIVNLKDEVLFDN------- 1533 southern plat...

1BNL_A         83 -------------WEALFSGseGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSATGQA 149  human
9_pfamImport   74 -------------WDAIFTQ--GGLKEGVPIYSFDGRDLLGDAAWPEKMLWHGSTGGGQRHTQGFCEAWRSGEQSQSGMA 138 
7_pfamImport   74 -------------WQSIFGEsvSKMRKNVPIYSFDGRDILRDSAWPEKMVWHGSSKKGHRQTDQYCEAWRAGDQAVTGLA 140 
4_pfamImport   74 -------------WESLFGDdvSKMRENVPIYSFDGRDVVRDSAWPEKMVWHGSSNKGHRQTDHYCETWRAGDHAVTGLA 140 
5_pfamImport   74 -------------WMSIFSGngGTFNPSTAIYSFDGRDVLSDPAWPEKLVWHGSNAVGIRLTTNYCEAWRTADMAVTGQA 140 
3_pfamImport   70 -------------WESIFNGngGQFDIHVPIYSFDGRNVMTDPFWPQKIIWHGSTTNGIRMVSNYCEAWHTANLAATGQA 136 
8_pfamImport   81 aphkvttecwgfqWFCLF--------------------------WHQKMVWHGSDPKGRRLPESYCETWRAGQQAALGQA 134 
XP_008108790 1281 -------------WENLFSGseASFRTGVRILSFDGRDVLRNPAWPQKYVWHGSDSKGRRLTENYCETWRTDDTVVTGQA 1347 green anole
AAH63929     1200 -------------WESLFSGseAQMRPGASIFSFDGKDVATDPTWPQKMVWHGSDSKGRRLTESYCETWRTDEGAVTGQA 1266 tropical claw...
XP_023185092 1534 -------------WNRIFSD--SRMRDNVSIYSFDGKDVLQDDTWPEKMMWHGSTSRGQRNVDSYCEAWRVGERALTGMA 1598 southern plat...
9_pfamImport   74 -------------WDAIFTQ--GGLKEGVPIYSFDGRDLLGDAAWPEKMLWHGSTGGGQRHTQGFCEAWRSGEQSQSGMA 138 
7_pfamImport   74 -------------WQSIFGEsvSKMRKNVPIYSFDGRDILRDSAWPEKMVWHGSSKKGHRQTDQYCEAWRAGDQAVTGLA 140 
4_pfamImport   74 -------------WESLFGDdvSKMRENVPIYSFDGRDVVRDSAWPEKMVWHGSSNKGHRQTDHYCETWRAGDHAVTGLA 140 
5_pfamImport   74 -------------WMSIFSGngGTFNPSTAIYSFDGRDVLSDPAWPEKLVWHGSNAVGIRLTTNYCEAWRTADMAVTGQA 140 
3_pfamImport   70 -------------WESIFNGngGQFDIHVPIYSFDGRNVMTDPFWPQKIIWHGSTTNGIRMVSNYCEAWHTANLAATGQA 136 
8_pfamImport   81 aphkvttecwgfqWFCLF--------------------------WHQKMVWHGSDPKGRRLPESYCETWRAGQQAALGQA 134 
XP_008108790 1281 -------------WENLFSGseASFRTGVRILSFDGRDVLRNPAWPQKYVWHGSDSKGRRLTENYCETWRTDDTVVTGQA 1347 green anole
AAH63929     1200 -------------WESLFSGseAQMRPGASIFSFDGKDVATDPTWPQKMVWHGSDSKGRRLTESYCETWRTDEGAVTGQA 1266 tropical claw...
XP_023185092 1534 -------------WNRIFSD--SRMRDNVSIYSFDGKDVLQDDTWPEKMMWHGSTSRGQRNVDSYCEAWRVGERALTGMA 1598 southern plat...

1BNL_A        150 SSLLGGR-LLGQSAASCHHAYIVLCIENSF 178  human
9_pfamImport  139 APLHSGSsLLQQHPGSCSSSYAVLCIENSY 168 
7_pfamImport  141 SSLQSSH-LLQQTPTSCSRACIVLCIENAM 169 
4_pfamImport  141 SSLQSGR-LLQQTSSSCSGSYVVLCIENAF 169 
5_pfamImport  141 ALLQTGR-LLGQHTRSCSNHYIVLCIENTY 169 
3_pfamImport  137 SPLKMGK-LLDQKAYSCNNRFIVLCIENSF 165 
8_pfamImport  135 SSLFSGK-LLEQRPASCSSSFIVLCIENSY 163 
XP_008108790 1348 SSLASGK-LLEQKSSNCKNAYIVLCIENSF 1376 green anole
AAH63929     1267 SSLTSGK-LLEQRPQSCNKNFIVLCIENSF 1295 tropical clawed frog
XP_023185092 1599 SPLQSRS-LLQQSSSSCSSSYIVLCVENSY 1627 southern platyfish
9_pfamImport  139 APLHSGSsLLQQHPGSCSSSYAVLCIENSY 168 
7_pfamImport  141 SSLQSSH-LLQQTPTSCSRACIVLCIENAM 169 
4_pfamImport  141 SSLQSGR-LLQQTSSSCSGSYVVLCIENAF 169 
5_pfamImport  141 ALLQTGR-LLGQHTRSCSNHYIVLCIENTY 169 
3_pfamImport  137 SPLKMGK-LLDQKAYSCNNRFIVLCIENSF 165 
8_pfamImport  135 SSLFSGK-LLEQRPASCSSSFIVLCIENSY 163 
XP_008108790 1348 SSLASGK-LLEQKSSNCKNAYIVLCIENSF 1376 green anole
AAH63929     1267 SSLTSGK-LLEQRPQSCNKNFIVLCIENSF 1295 tropical clawed frog
XP_023185092 1599 SPLQSRS-LLQQSSSSCSSSYIVLCVENSY 1627 southern platyfish
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