1BNL,1DY2


Conserved Protein Domain Family
Endostatin

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pfam06482: Endostatin (This model is not part of the current CDD release)
Collagenase NC10 and Endostatin
NC10 stands for Non-helical region 10. A mutation in this region in the human Collagen alpha-1(XVIII) chain is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to.
Statistics
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PSSM-Id: 517299
Aligned: 13 rows
Threshold Bit Score: 279.719
Created: 14-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1BNL_A          10 LHLVALNAPLSGGMRGIRGADFQCFQQARAVGLAGTFRAFLSSRLQD--LYSIVRRADRAAVPIVNLK--DELLFPS--- 82   human
7_pfamImport     1 LHLIALNSPQTGSMRGIRGADYLCFTQAQAVGLKGTFRAFLSARLQD--LHSIVRKADRDRVPIVNLK--DEVLFDS--- 73  
10_pfamImport    1 LHLIALNGPQTGAMQGIRGADFLCFTQAQAIGMKGTFRAFLSSRLQD--LHSIVRRTDRERIPIVNLK--DEVLFDS--- 73  
8_pfamImport     1 LRLIALNTPQSGNMKGIRGPDYLCFEQARAAGLRGTFRAFLSSKVQD--LHTIVRHSDREKPPIVNLK--NQVLFDS--- 73  
9_pfamImport     1 LHLIALNTPLTGDMRGIRGVDFQCFQQARSVGLMGTFRAFLSSRLQD--LYSIVRRADRTNVPIVNLR--DRLLSPSvpv 76  
11_pfamImport    1 LHLIALNSPQTGSMRGIRGADFLCFTQAQAIGMKGTFRAFLSSRLQD--LHSIVRKTDRQNLSVVNLK--DEVLFDS--- 73  
13_pfamImport    1 LHLIALNSPQKGGMRGISGADFLCFSQAQAIGMKGTFRAFLSSKLED--LNSIVYSSNRENVPIVNLK--DEVLFDN--- 73  
1_pfamImport     1 LHLIALNSPQVGNMRGIRGADFLCFQQAPSLERKNPYRLLPSVLLEEhiLQAVLEQSKPESTNIRTSKfmDQVMFDS--- 77  
1DY2_A          10 LHLVALNTPVAGDIR----ADFQCFQQARAAGLLSTFRAFLSSHLQD--LSTVVRKAERFGLPIVNLK--GQVLFNN--- 78   house mouse
XP_056706972  1694 LHLIALNTPLSGSMRGIRGADFQCFQQAREVGLTGTFRAFLSSRLQD--LYSIVRRADRSTVPIVNLR--DEMLFAN--- 1766 tarantolino
XP_025003384   830 LHLVALNLPFSGDMR----ADFHCFQQSQQAGLMTTYRAFLSSHLQD--LVTVVRKTDRYNLPIVNLK--GETLFNN--- 898  chicken
XP_029687360  1070 LHLVALNSPLRGDMRGIRGADFQCYQQARSMGLTSTYRAFLSSHLQD--LATIVRKADRTDMPVVNLR--GEVLFSS--- 1142 torafugu
XP_011610514  1143 LHLIALNAPHTGNMRGIRGADFLCFQQARAIGLKGTFRAFLSSKLQD--LYTIVRRSDRDNFPIVNLK--DQVLFRS--- 1215 torafugu
1BNL_A          83 -----------------WEALFSGseGPLKPGARIFSFDGKDVLRHPTWPQKSVWHGSDPNGRRLTESYCETWRTEAPSA 145  human
7_pfamImport    74 -----------------WDAVFND--GRVKDNVPIYSFDGKDVLNDGTWPDKMVWHGSTGGGQGHVDGMCEMWRVDNRAV 134 
10_pfamImport   74 -----------------WDAIFTQ--GGLKEGVPIYSFDGRDLLGDAAWPEKMLWHGSTGGGQRHTQGFCEAWRSGEQSQ 134 
8_pfamImport    74 -----------------WQSIFGEsvSKMRKNVPIYSFDGRDILRDSAWPEKMVWHGSSKKGHRQTDQYCEAWRAGDQAV 136 
9_pfamImport    77 gshmaphkvttecwgfqWFCLF--------------------------WHQKMVWHGSDPKGRRLPESYCETWRAGQQAA 130 
11_pfamImport   74 -----------------WDDIFSG--GRMKENVSIYSFDGKDVLYDNTWPEKMVWHGSTSRGERHVDSFCETWRVGEQAL 134 
13_pfamImport   74 -----------------WNRIFSD--SRMRDNVSIYSFDGKDVLQDDTWPEKMMWHGSTSRGQRNVDSYCEAWRVGERAL 134 
1_pfamImport    78 -----------------WESLFSGsdGQMKPNAPIYSFDGRDILRDSHWPQKMVWHGSNSKGHRLTDNYCETWRTEDRAV 140 
1DY2_A          79 -----------------WDSIFSGdgGQFNTHIPIYSFDGRDVMTDPSWPQKVVWHGSNPHGVRLVDKYCEAWRTTDMAV 141  house mouse
XP_056706972  1767 -----------------WEYLFSGseAPFRTGVRIFSFDGRDVLRDSAWPQKSVWHGSDSKGRRLTESYCETWRTDDTVV 1829 tarantolino
XP_025003384   899 -----------------WESIFDGngGQFNIHVPIYSFDGRNVMTDPFWPQKIIWHGSTTNGIRLVSNYCEAWHTADLAA 961  chicken
XP_029687360  1143 -----------------WMSIFSGngGTFNPSLPVYSFDGRDVMTDPAWPEKLVWHGSSTVGIRLTANYCEAWRTGDPAV 1205 torafugu
XP_011610514  1216 -----------------WESMFGDeaSKITENVPIYSFDGRDILRDSAWPEKMVWHGSSNKGHRQTDQYCETWRAGDRAV 1278 torafugu
1BNL_A         146 TGQASSLLGGR-LLGQSAASCHHAYIVLCIENSF 178  human
7_pfamImport   135 TGMASPLQSGS-LLQASASSCSGSYVVLCIENSY 167 
10_pfamImport  135 SGMAAPLHSGSsLLQQHPGSCSSSYAVLCIENSY 168 
8_pfamImport   137 TGLASSLQSSH-LLQQTPTSCSRACIVLCIENAM 169 
9_pfamImport   131 LGQASSLFSGK-LLEQRPASCSSSFIVLCIENSY 163 
11_pfamImport  135 TGMASPLQSGS-LLQQSSSSCSSSNVVLCIENSQ 167 
13_pfamImport  135 TGMASPLQSRS-LLQQSSSSCSSSYIVLCVENSY 167 
1_pfamImport   141 TGFASSLESGQ-LLQQRPQSCSNSFIVLCIENSY 173 
1DY2_A         142 TGFASPLSTGK-ILDQKAYSCANRLIVLCIENSF 174  house mouse
XP_056706972  1830 TGQAASLASGK-LLEQKSSSCKNAFVVLCIENSF 1862 tarantolino
XP_025003384   962 MGQASPLNTGK-LLDQKTYSCNNRFIVLCIENSF 994  chicken
XP_029687360  1206 TGQAALLQTGR-LLGQHARPCARHHIVLCVENTY 1238 torafugu
XP_011610514  1279 TGLASSLKSGY-LLQQSASSCSGSYVVLCIENAF 1311 torafugu
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